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Bone Marrow Mesenchymal Stem Cell Therapy for Voiding Dysfunction

  • Regenerative Medicine (A Atala, Section Editor)
  • Published:
Current Urology Reports Aims and scope Submit manuscript

Abstract

Lower urinary tract symptoms can significantly impact quality of life. Current standard treatments are not always effective and are associated with complications and side effects. The discovery of stem cells led to research into cell-based therapies for treatment of disorders of voiding dysfunction. Bone marrow mesenchymal stem cells are particularly promising given their ability to differentiate into a variety of cell types. Recent studies have investigated bone marrow stem cells to treat a number of functional voiding pathologies including bladder outlet obstruction, neurogenic bladder, and stress urinary incontinence. Experiments in tissue regeneration have also attempted to create artificial bladders and urethras. The purpose of this article is to critically review the literature regarding the use of bone marrow mesenchymal stem cells in treatment of voiding dysfunction.

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Abbreviations

BMSC:

Bone marrow mesenchymal stem cell

BOO:

Bladder outlet obstruction

LPP:

Leak point pressure

MSC:

Mesenchymal stem cell

SCI:

Spinal cord injury

SUI:

Stress urinary incontinence

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Conflict of Interest

Alice Yu and Lysanne Campeau each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Division of Urology, Department of Surgery, Jewish General Hospital, McGill University, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1E2, Canada

    Alice Yu & Lysanne Campeau

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  1. Alice Yu
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  2. Lysanne Campeau
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Correspondence to Lysanne Campeau.

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This article is part of the Topical Collection on Regenerative Medicine

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Yu, A., Campeau, L. Bone Marrow Mesenchymal Stem Cell Therapy for Voiding Dysfunction. Curr Urol Rep 16, 49 (2015). https://doi.org/10.1007/s11934-015-0516-8

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  • DOI: https://doi.org/10.1007/s11934-015-0516-8

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