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Exogenous miRNA: A Perspective Role as Therapeutic in Rheumatoid Arthritis

  • Rheumatoid Arthritis (L Moreland, Section Editor)
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Abstract

Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease that causes joint deformation. Till now several studies has been carried out promising its cure, but curing has not yet achieved to the satisfactory levels. Herbal approach to treat disease by a cross-kingdom mechanism via exogenous miRNA is an emerging trend to target associated genes with RA pathogenesis as a therapeutic potential. The concept of acquired/exogenous miRNA into pathophysiological prospect provides an opportunity to explore inter-species kingdom like regulation of plant miRNAs on human health. The change in gene expression was attributed by a short 22-24 nucleotide long sequence that binds to its complementary region to suppress/silence the gene expression. This makes exogenous miRNA a novel approach for targeted therapy to treat complex chronic inflammatory diseases. Here, aim of the review was to address significance of plant derived miRNA based targeted therapy to regulate inflammation in RA.

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Acknowledgement

We acknowledge Council of Scientific and Industrial Research (CSIR), Project code MLP 2013 and Department of Science and Technology (DST), Government of India, New Delhi, India for providing financial support. Mohd Saquib received fellowship support from CSIR, Prachi Agnihotri received fellowship from DST project GAP0212, and Monu received fellowship support from CSIR. We also thank Council of Scientific and Industrial Research (CSIR)-Institute of Genomics and Integrative Biology, Delhi, India for research and AcSIR for academic support.

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  1. CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India

    Mohd Saquib, Prachi Agnihotri,  Monu & Sagarika Biswas

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

    Mohd Saquib &  Monu

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This article is part of the Topical Collection on Rheumatoid Arthritis

Key message

• Functional implication of plant miRNAs in human is a useful strategy in therapeutic aspect.

• Plant exogenous miRNA and host mRNA interactions might have a potential role in the alteration of genetic regulation of host cellular machinery.

• The ability of plant miRNA to regulate the cross-kingdom mRNA translation can be used for the treatment of RA.

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Saquib, M., Agnihotri, P., Monu et al. Exogenous miRNA: A Perspective Role as Therapeutic in Rheumatoid Arthritis. Curr Rheumatol Rep 23, 43 (2021). https://doi.org/10.1007/s11926-021-01009-7

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