Skip to main content

Advertisement

Log in

Headache Management in the Neuroscience Intensive Care Unit

  • Secondary Headache (M Robbins, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Headache is a common symptom in the Neuroscience Intensive Care Unit (NeuroICU). Our goal is to provide an overview of approaches to headache management for common neurocritical care conditions.

Recent Findings

Headache disorders afflict nearly half of patients admitted to the NICU. Commonly encountered disorders featuring headache include cerebrovascular disease, trauma, and intracranial infection. Approaches to pain are highly variable, and multimodal pain regimens are commonly employed. The overall body of evidence supporting therapeutic strategies to manage headache in the critical care setting is slim, and pain control remains suboptimal in many cases with persistent reliance on opioids.

Summary

Headache is a complex, frequently occurring phenomenon in the NeuroICU care setting. At present, literature on evidence-based practice for management of headache in the critical care setting remains scarce, and despite multimodal approaches, reliance on opioids is commonplace.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of special importance •• Of outstanding importance

  1. Stovner LJ, Hagen K, Linde M, Steiner TJ. The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. J Headache Pain. 2022;23:1–17. https://doi.org/10.1186/s10194-022-01402-2.

    Article  Google Scholar 

  2. Vukasinovic N, Jolic S, Milosevic V, Zivkovic M, Slankamenac P. EHMTI-0128. Headache as an initial symptom with the patients treated at the intensive care unit of the Clinic of Neurology 1997 – 2013. J Headache Pain. 2014;15:D75. https://doi.org/10.1186/1129-2377-15-S1-D75.

  3. Morad A, Farrokh S, Papangelou A. Pain management in neurocritical care. An update Curr Opin Crit Care. 2018;24:72–9. https://doi.org/10.1097/MCC.0000000000000480.

    Article  PubMed  Google Scholar 

  4. Dhakal LP, Harriott AM, Capobianco DJ, Freeman WD. Headache and its approach in today’s neurointensive care unit. Neurocrit Care. 2016;25:320–34. https://doi.org/10.1007/s12028-016-0260-z.

    Article  PubMed  Google Scholar 

  5. • Maciel CB, Barlow B, Lucke-Wold B, Gobinathan A, Abu-Mowis Z, Peethala MM, et al. Acute headache management for patients with subarachnoid hemorrhage: an international survey of health care providers. Neurocrit Care. 2023;38:395–406. https://doi.org/10.1007/s12028-022-01571-7This comprehensive international survey characterizes health care providers diverse practices for management of acute headache in SAH patients.

  6. •• Klavansky D, Wanchoo S, Lin A, Temes RE, Rebeiz T. Predictors of opiate utilization in the treatment of headache and impact on three-month outcomes following subarachnoid hemorrhage. Cureus. 2021. https://doi.org/10.7759/cureus.20773. This is a cross-sectional study covering important aspects of increased opioid use for headache management during and after hospitalization.

  7. Cutrer MF, O’donnell A. Pathophysiology of headaches. In: Warfield CA, Bajwa ZH, editors. Principles & Practice of Pain Medicine, New York: McGraw-Hill; 2004. p. 1–9.

  8. Chowdhury T, Garg R, Sheshadri V, Venkatraghavan L, Bergese SD, Cappellani RB, et al. Perioperative factors contributing the post-craniotomy pain: a synthesis of concepts. Front Med. 2017;4:1–5. https://doi.org/10.3389/fmed.2017.00023.

    Article  Google Scholar 

  9. •• Sorrentino ZA, Laurent D, Hernandez J, Davidson C, Small C, Dodd W, et al. Headache persisting after aneurysmal subarachnoid hemorrhage: a narrative review of pathophysiology and therapeutic strategies. Headache. 2022;62:1120–32. https://doi.org/10.1111/head.14394This is a very comprehensive review article covering important aspects of pathophysiology to gain a broad understanding and treatment approach.

  10. Arboix A, García-Trallero O, García-Eroles L, Massons J, Comes E, Targa C. Stroke-related headache: a clinical study in lacunar infarction. Headache. 2005;45:1345–52. https://doi.org/10.1111/j.1526-4610.2005.00267.x.

    Article  PubMed  Google Scholar 

  11. •• Rasouli J, Watson C, Yaeger K, Ladner T, Kellner C, Dangayach NS. Pain control after aneurysmal subarachnoid hemorrhage: a contemporary literature review. J Clin Neurosci. 2019;68:9–12. https://doi.org/10.1016/j.jocn.2019.07.057This is a great contemporary literature review of pain control in subarachnoid hemorrhage which provides a valuable framework and recommendations.

  12. Xu L, Wang W, Lai N, Tong J, Wang G, Tang D. Association between pro-inflammatory cytokines in cerebrospinal fluid and headache in patients with aneurysmal subarachnoid hemorrhage. J Neuroimmunol. 2022;366:577841. https://doi.org/10.1016/j.jneuroim.2022.577841.

    Article  CAS  PubMed  Google Scholar 

  13. Swope R, Glover K, Gokun Y, Fraser JF, Cook AM. Evaluation of headache severity after aneurysmal subarachnoid hemorrhage. Interdiscip Neurosurg. 2014;1:119–22. https://doi.org/10.1016/j.inat.2014.07.003.

    Article  Google Scholar 

  14. Leira R, Castellanos M, Älvarez-Sabín J, Diez-Tejedor E, Dávalos A, Castillo J, et al. Headache in cerebral hemorrhage is associated with inflammatory markers and higher residual cavity. Headache. 2005;45:1236–43. https://doi.org/10.1111/j.1526-4610.2005.00248.x.

    Article  PubMed  Google Scholar 

  15. Oliveira FAA, Sampaio Rocha-Filho PA. Headaches attributed to ischemic stroke and transient ischemic attack. Headache. 2019;59:469–76. https://doi.org/10.1111/head.13478.

    Article  PubMed  Google Scholar 

  16. Chen SP, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. J Biomed Sci. 2022;29:1–13. https://doi.org/10.1186/s12929-022-00857-4.

    Article  CAS  Google Scholar 

  17. Eisinger RS, Sorrentino ZA, Lucke-Wold B, Zhou S, Barlow B, Hoh B, et al. Severe headache trajectory following aneurysmal subarachnoid hemorrhage: the association with lower sodium levels. Brain Inj. 2022;36:579–85. https://doi.org/10.1080/02699052.2022.2055146.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Garg R, Bar B. Systemic complications following aneurysmal subarachnoid hemorrhage. Curr Neurol Neurosci Rep. 2017;17:1–7. https://doi.org/10.1007/s11910-017-0716-3.

    Article  Google Scholar 

  19. Dorhout Mees SM, Bertens D, Van Der Worp HB, Rinkel GJE, Van Den Bergh WM. Magnesium and headache after aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 2010;81:490–3. https://doi.org/10.1136/jnnp.2009.181404.

    Article  CAS  PubMed  Google Scholar 

  20. Ashina H, Porreca F, Anderson T, Mohammad Amin F, Ashina M, Winther Schytz H, et al. Post-traumatic headache: epidemiology and pathophysiological insights. Nat Rev Neurol. 2019;15:607–17. https://doi.org/10.1038/s41582-019-0243-8.

    Article  PubMed  Google Scholar 

  21. Lin J, Zhang S, He F, Liu M, Ma X. The status of diagnosis and treatment to intracranial hypotension, including SIH. J Headache Pain. 2017;18:1–8. https://doi.org/10.1186/s10194-016-0708-8.

    Article  Google Scholar 

  22. Cruz SL, Granados-Soto V. Opioids and opiates: pharmacology, abuse, and addiction. In: Pfaff DW, Volkow ND, editors. Neuroscience in the 21st Century. New York: Springer; 2015;1–33.

    Google Scholar 

  23. • Lin N, Mandel D, Chuck CC, Kalagara R, Doelfel SR, Zhou H, et al. Risk factors for opioid utilization in patients with intracerebral hemorrhage. Neurocrit Care. 2022;36:964–73. https://doi.org/10.1007/s12028-021-01404-zThis retrospective cohort study provides a novel up-to-date description of opioid in patient and discharge prescription patterns in ICH patients and its relationship with dependence.

  24. •• Viswanathan V, Lucke-Wold B, Jones C, Aiello G, Li Y, Ayala A, et al. Change in opioid and analgesic use for headaches after aneurysmal subarachnoid hemorrhage over time. Neurochirurgie. 2021;67:427–32. https://doi.org/10.1016/j.neuchi.2021.03.006This article provides an excellent overview of heavy reliance on opioid usage in SAH patients, which demands attention due to the ongoing opioid crisis.

  25. Higgins C, Smith BH, Matthews K. Incidence of iatrogenic opioid dependence or abuse in patients with pain who were exposed to opioid analgesic therapy: a systematic review and meta-analysis. Br J Anaesth. 2018;120:1335–44. https://doi.org/10.1016/j.bja.2018.03.009.

    Article  CAS  PubMed  Google Scholar 

  26. Vowles KE, McEntee ML, Julnes PS, Frohe T, Ney JP, Van Der Goes DN. Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain. 2015;156:569–76. https://doi.org/10.1097/01.j.pain.0000460357.01998.f1.

    Article  PubMed  Google Scholar 

  27. Brat GA, Agniel D, Beam A, Yorkgitis B, Bicket M, Homer M, et al. Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study. BMJ. 2018;360:1–9. https://doi.org/10.1136/bmj.j5790.

    Article  Google Scholar 

  28. Higginbotham JA, Markovic T, Massaly N, Morón JA. Endogenous opioid systems alterations in pain and opioid use disorder. Front Syst Neurosci. 2022;16:1–24. https://doi.org/10.3389/fnsys.2022.1014768.

    Article  CAS  Google Scholar 

  29. Friedman BW, Irizarry E, Cain D, Caradonna A, Minen MT, Solorzano C, et al. Randomized study of metoclopramide plus diphenhydramine for acute posttraumatic headache. Neurology. 2021;96:E2323–31. https://doi.org/10.1212/WNL.0000000000011822.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Jaadi S Al, Al-Kindi Y, Al-Saadi T. Safety of metoclopramide in traumatic brain injury patients. Indian J Neurotrauma. 2020;19:122–6. https://doi.org/10.1055/s-0040-1717213.

  31. Arumugam S, Lau CSM, Chamberlain RS. Use of preoperative gabapentin significantly reduces postoperative opioid consumption: a meta-analysis. J Pain Res. 2016;9:631–40. https://doi.org/10.2147/JPR.S112626.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Hah JM, Bateman BT, Ratliff J, Curtin C, Sun E. Chronic opioid use after surgery: implications for perioperative management in the face of the opioid epidemic. Anesth Analg. 2017;125:1733–40. https://doi.org/10.1213/ANE.0000000000002458.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Gaastra B, Carmichael H, Galea I, Bulters D. Duration and characteristics of persistent headache following aneurysmal subarachnoid hemorrhage. Headache. 2022;62:1376–82. https://doi.org/10.1111/head.14418.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Huckhagel T, Klinger R, Schmidt NO, Regelsberger J, Westphal M, Czorlich P. The burden of headache following aneurysmal subarachnoid hemorrhage: a prospective single-center cross-sectional analysis. Acta Neurochir. 2020;162:893–903. https://doi.org/10.1007/s00701-020-04235-7.

    Article  PubMed  Google Scholar 

  35. • Smith CR, Fox WC, Robinson CP, Garvan C, Babi MA, Pizzi MA, et al. Pterygopalatine fossa blockade as novel, narcotic-sparing treatment for headache in patients with spontaneous subarachnoid hemorrhage. Neurocrit Care. 2021;35:241–8. https://doi.org/10.1007/s12028-020-01157-1This is an auspicious and novel case series treatment approach for pain treatment in SAH patients. This promising opioid-sparing therapeutic strategy is currently being addressed in a randomized controlled trial.

  36. Morotti A, Goldstein JN. Diagnosis and management of acute intracerebral hemorrhage. Emerg Med Clin North Am. 2016;34:883–99. https://doi.org/10.1016/j.emc.2016.06.010.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Ribas MZ, Paticcié GF, de Medeiros SDP, de Oliveira VA, Noleto FM, dos Santos JCC. Reversible cerebral vasoconstriction syndrome: literature review. Egypt J Neurol Psychiatr Neurosurg. 2023;59:5. https://doi.org/10.1186/s41983-023-00607-9.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Jafari S, Albin C, Izzy S. Cerebral Venous Thrombosis. In: Fawaz A-M, Krishna A, editors. Cerebrovascular disorders. New York: Humana Press; 2021;379–94.

    Chapter  Google Scholar 

  39. • Ashina H, Al-Khazali HM, Iljazi A, Ashina S, Amin FM, Schytz HW. Total tenderness score and pressure pain thresholds in persistent post-traumatic headache attributed to mild traumatic brain injury. J Headache Pain. 2022;23:1–8. https://doi.org/10.1186/s10194-022-01457-1This study provides a novel understanding of the pathophysiology of headache in patients with persistent post-traumatic headache. It provides a broad framework for a frequent pathology among population.

  40. Lew HL, Lin PH, Fuh JL, Wang SJ, Clark DJ, Walker WC. Characteristics and treatment of headache after traumatic brain injury: a focused review. Am J Phys Med Rehabil. 2006;85:619–27. https://doi.org/10.1097/01.phm.0000223235.09931.c0.

    Article  PubMed  Google Scholar 

  41. Olesen J, Bes A, Kunkel R, Lance JW, Nappi G, Pfaffenrath V, et al. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629–808. https://doi.org/10.1177/0333102413485658.

  42. Lutman B, Bloom J, Nussenblatt B, Romo V. A contemporary perspective on the management of post-craniotomy headache and pain. Curr Pain Headache Rep. 2018;22:1–7. https://doi.org/10.1007/s11916-018-0722-4.

    Article  Google Scholar 

  43. Pajor MJ, Long B, Koyfman A, Liang SY. High risk and low prevalence diseases: adult bacterial meningitis. Am J Emerg Med. 2023;65:76–83. https://doi.org/10.1016/j.ajem.2022.12.042.

    Article  PubMed  Google Scholar 

  44. Kohil A, Jemmieh S, Smatti MK, Yassine HM. Viral meningitis: an overview. Arch Virol. 2021;166:335–45. https://doi.org/10.1007/s00705-020-04891-1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Kumar S, Verma R, Garg RK, Malhotra HS, Sharma PK. Prevalence and outcome of headache in tuberculous meningitis. Neurosciences. 2016;21:138–44. https://doi.org/10.17712/nsj.2016.2.2015678.

  46. Sampaio Rocha-Filho PA. Headache associated with COVID-19: Epidemiology, characteristics, pathophysiology, and management. Headache. 2022;62:650–6. https://doi.org/10.1111/head.14319.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Palmieri A, Valentinis L, Zanchin G. Update on headache and brain tumors. Cephalalgia. 2021;41:431–7. https://doi.org/10.1177/0333102420974351.

    Article  PubMed  Google Scholar 

  48. Schievink WI. Spontaneous intracranial hypotension. N Engl J Med. 2021;385:2173–8. https://doi.org/10.1056/NEJMra2101561.

    Article  PubMed  Google Scholar 

  49. Lee RP, Chaichana KL, Huang J, Tamargo RJ, Caplan JM. Neurosurgical emergencies. In: Nelson SE, Nyquist PA, editors. Neurointensive Care Unit: Clinical Practice and Organization. Cham: Humana; 2020;195–230.

    Chapter  Google Scholar 

  50. Jackson CM, Caplan JM, Huang J, Tamargo RJ. Treatment of subarachnoid hemorrhage in the neurocritical care unit. In: Nelson SE, Nyquist PA, editors. Neurointensive Care Unit: Clinical Practice and Organization. Cham: Humana; 2020;121–37.

    Chapter  Google Scholar 

  51. Gusdon AM, Nyquist PA, Nelson SE. Management of elevated intracranial pressure. In: Nelson SE, Nyquist PA, editors. Neurointensive Care Unit: Clinical Practice and Organization. Cham: Humana; 2020;3–19.

    Chapter  Google Scholar 

  52. Friedman DI. Headaches due to low and high intracranial pressure. Continuum. 2018;24:1066–91. https://doi.org/10.1212/CON.0000000000000623.

    Article  PubMed  Google Scholar 

  53. Viarasilpa T, Ghosh P, Gidwani S, Lantigua H, De Marchis GM, Panyavachiraporn N, et al. Prognostic significance of sentinel headache preceding aneurysmal subarachnoid hemorrhage. World Neurosurg. 2020;139:e672–6. https://doi.org/10.1016/j.wneu.2020.04.097.

    Article  PubMed  Google Scholar 

  54. Steiner T, Juvela S, Unterberg A, Jung C, Forsting M, Rinkel G, et al. European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis. 2013;35:93–112. https://doi.org/10.1159/000346087.

    Article  PubMed  Google Scholar 

  55. Morad AH, Tamargo RJ, Gottschalk A. The longitudinal course of pain and analgesic therapy following aneurysmal subarachnoid hemorrhage: a cohort study. Headache. 2016;56:1617–25. https://doi.org/10.1111/head.12908.

    Article  PubMed  Google Scholar 

  56. Hile GB, Cook AM. Treatment of headache in aneurysmal subarachnoid hemorrhage: Multimodal approach. Interdiscip Neurosurg. 2020;22(100857):1–5. https://doi.org/10.1016/j.inat.2020.100857.

    Article  Google Scholar 

  57. Jaffa MN, Podell JE, Foroutan A, Motta M, Chang W-TW, Cherian J, et al. Steroids provide temporary improvement of refractory pain following subarachnoid hemorrhage. Neurohospitalist. 2023;13:236–42. https://doi.org/10.1177/19418744231172350.

  58. Glisic EK, Gardiner L, Josti L, Dermanelian E, Ridel S, Dziodzio J, et al. Inadequacy of headache management after subarachnoid hemorrhage. Am J Crit Care. 2016;25:136–43. https://doi.org/10.4037/ajcc2016486.

    Article  PubMed  Google Scholar 

  59. Terakado T, Nakai Y, Ikeda G, Uemura K, Matsumaru Y, Ishikawa E, et al. Effectiveness of low-dose intravenous fentanyl for postoperative headache management after neck clipping of ruptured intracranial aneurysms. World Neurosurg. 2020;134:e339–45. https://doi.org/10.1016/j.wneu.2019.10.062.

    Article  PubMed  Google Scholar 

  60. Lionel KR, Sethuraman M, Abraham M, Vimala S, Prathapadas U, Hrishi AP. Effect of pregabalin on perioperative headache in patients with aneurysmal subarachnoid hemorrhage: a randomized double-blind, placebo-controlled trial. J Neurosci Rural Pract. 2019;10:438–43. https://doi.org/10.1055/s-0039-1697871.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Dhakal LP, Turnbull MT, Jackson DA, Edwards E, Hodge DO, Thottempudi N, et al. Safety, tolerability, and efficacy of pain reduction by gabapentin for acute headache and meningismus after aneurysmal subarachnoid hemorrhage: a pilot study. Front Neurol. 2020;11(744):1–8. https://doi.org/10.3389/fneur.2020.00744.

    Article  Google Scholar 

  62. Doǧan R, Pinar HU, Karaca Ö, Karakoç F. Ultrasound-guided bilateral greater occipital nerve block on headache seen after endovascular treatment of ruptured or unruptured intracranial aneurysms: a case report. Agri. 2020;32:223–7. https://doi.org/10.5505/agri.2018.59023.

    Article  PubMed  Google Scholar 

  63. Kropp P, Holzhausen M, Kolodny E, Becker U, Dichgans M, Diez-Tejedor E, et al. Headache as a symptom at stroke onset in 4,431 young ischaemic stroke patients. Results from the “stroke in young fabry patients (SIFAP1) study.” J Neural Transm. 2013;120:1433–40. https://doi.org/10.1007/s00702-013-1014-0.

  64. Hesami O, Gharagozli K, Beladimoghadam N, Assarzadegan F, Mansouri B, Sistanizad M. The efficacy of gabapentin in patients with central post-stroke pain. Iran J Pharm Res. 2015;14:95–101.

    CAS  PubMed  PubMed Central  Google Scholar 

  65. Attal N, Guirimand F, Brasseur L, Gaude V, Chauvin M, Bouhassira D. Effects of IV morphine in central pain: a randomized placebo-controlled study. Neurology. 2002;58:554–63. https://doi.org/10.1212/wnl.58.4.554.

    Article  CAS  PubMed  Google Scholar 

  66. Cappelen-Smith C, Calic Z, Cordato D. Reversible cerebral vasoconstriction syndrome: recognition and treatment. Curr Treat Options Neurol. 2017;19. https://doi.org/10.1007/s11940-017-0460-7.

  67. Song T-J, Lee KH, Li H, Kim JY, Chang K, Kim SH, et al. Reversible cerebral vasoconstriction syndrome: a comprehensive systematic review. Eur Rev Med Pharmacol Sci. 2021;25:3519–29. https://doi.org/10.26355/eurrev_202105_25834.

  68. Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain. 2007;130:3091–101. https://doi.org/10.1093/brain/awm256.

  69. Chen S-P, Fuh J-L, Lirng J-F, Chang F-C, Wang S-J. Recurrent primary thunderclap headache and benign CNS angiopathy: spectra of the same disorder?. Neurology. 2006;67:2164–9. https://doi.org/10.1212/01.wnl.0000249115.63436.6d.

  70. Idiculla PS, Gurala D, Palanisamy M, Vijayakumar R, Dhandapani S, Nagarajan E. Cerebral venous thrombosis: a comprehensive review. Eur Neurol. 2020;83:369–79. https://doi.org/10.1159/000509802.

    Article  PubMed  Google Scholar 

  71. Canhão P, Cortesão A, Cabral M, Ferro JM, Stam J, Bousser MG, et al. Are steroids useful to treat cerebral venous thrombosis? Stroke. 2008;39:105–10. https://doi.org/10.1161/STROKEAHA.107.484089.

    Article  CAS  PubMed  Google Scholar 

  72. Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ. Cerebral venous thrombosis: a practical guide. Pract Neurol. 2020;20:356–67. https://doi.org/10.1136/practneurol-2019-002415.

    Article  PubMed  Google Scholar 

  73. Chowdhury D, Mundra A, Datta D, Duggal A, Krishnan A, Koul A. Efficacy and tolerability of combination treatment of topiramate and greater occipital nerve block versus topiramate monotherapy for the preventive treatment of chronic migraine: a randomized controlled trial. Cephalalgia. 2022;42:859–71. https://doi.org/10.1177/03331024221082077.

    Article  PubMed  Google Scholar 

  74. •• Ashina H, Eigenbrodt AK, Seifert T, Sinclair AJ, Scher AI, Schytz HW, et al. Post-traumatic headache attributed to traumatic brain injury: classification, clinical characteristics, and treatment. Lancet Neurol. 2021;20:460–9. https://doi.org/10.1016/S1474-4422(21)00094-6This article provides an excellent overview and a novel proposed algorithm for pharmacological treatment of post-traumatic headache in TBI.

  75. Larsen EL, Ashina H, Iljazi A, Al-Khazali HM, Seem K, Ashina M, et al. Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review. J Headache Pain. 2019;20:1–9. https://doi.org/10.1186/s10194-019-1051-7.

    Article  CAS  Google Scholar 

  76. Ashina H, Iljazi A, Al-Khazali HM, Ashina S, Jensen RH, Amin FM, et al. Persistent post-traumatic headache attributed to mild traumatic brain injury: deep phenotyping and treatment patterns. Cephalalgia. 2020;40:554–64. https://doi.org/10.1177/0333102420909865.

    Article  PubMed  Google Scholar 

  77. Packard RC. Treatment of chronic daily posttraumatic headache with divalproex sodium. Headache. 2000;40:736–9. https://doi.org/10.1046/j.1526-4610.2000.00128.x.

    Article  CAS  PubMed  Google Scholar 

  78. Vadivelu N, Kai AM, Tran D, Kodumudi G, Legler A, Ayrian E. Options for perioperative pain management in neurosurgery. J Pain Res. 2016;9:37–47. https://doi.org/10.2147/JPR.S85782.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Hassani E, Mahoori A, Sane S, Tolumehr A. Comparison the effects of paracetamol with sufentanil infusion on postoperative pain control after craniotomy in patients with brain tumor. Adv Biomed Res. 2015;4:1–4. https://doi.org/10.4103/2277-9175.152610.

    Article  CAS  Google Scholar 

  80. Dunn LK, Naik BI, Nemergut EC, Durieux ME. Post-craniotomy pain management: beyond opioids. Curr Neurol Neurosci Rep. 2016;16:1–10. https://doi.org/10.1007/s11910-016-0693-y.

    Article  CAS  Google Scholar 

  81. Jones SJ, Cormack J, Murphy MA, Scott DA. Parecoxib for analgesia after craniotomy. Br J Anaesth. 2009;102:76–9. https://doi.org/10.1093/bja/aen318.

    Article  CAS  PubMed  Google Scholar 

  82. Williams DL, Pemberton E, Leslie K. Effect of intravenous parecoxib on post-craniotomy pain. Br J Anaesth. 2011;107:398–403. https://doi.org/10.1093/bja/aer223.

    Article  CAS  PubMed  Google Scholar 

  83. Jaffa MN, Jha RM, Elmer J, Kardon A, Podell JE, Zusman BE, et al. Pain trajectories following subarachnoid hemorrhage are associated with continued opioid use at outpatient follow-up. Neurocrit Care. 2021;35:806–14. https://doi.org/10.1007/s12028-021-01282-5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Rahimi SY, Alleyne CH, Vernier E, Witcher MR, Vender JR. Postoperative pain management with tramadol after craniotomy: evaluation and cost analysis. J Neurosurg. 2010;112:268–72. https://doi.org/10.3171/2008.9.17689.

    Article  CAS  PubMed  Google Scholar 

  85. Misra S, Parthasarathi G, Vilanilam GC. The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. J Neurosurg Anesthesiol. 2013;25:386–91. https://doi.org/10.1097/ANA.0b013e31829327eb.

    Article  PubMed  Google Scholar 

  86. Guilfoyle MR, Helmy A, Duane D, Hutchinson PJA. Regional scalp block for postcraniotomy analgesia: a systematic review and meta-analysis. Anesth Analg. 2013;116:1093–102. https://doi.org/10.1213/ANE.0b013e3182863c22.

    Article  PubMed  Google Scholar 

  87. Zirovich MD, Pangarkar SS, Manh C, Chen L, Vangala S, Elashoff DA, et al. Botulinum toxin type a for the treatment of post-traumatic headache: a randomized, placebo-controlled, cross-over study. Mil Med. 2021;186:493–9. https://doi.org/10.1093/milmed/usaa391.

    Article  PubMed  Google Scholar 

  88. Davis LE. Acute bacterial meningitis. Continuum. 2018;24:1264–83. https://doi.org/10.1212/CON.0000000000000660.

  89. Krymchantowski AV, Silva-Néto RP, Jevoux C, Krymchantowski AG. Indomethacin for refractory COVID or post-COVID headache: a retrospective study. Acta Neurol Belg. 2022;122:465–9. https://doi.org/10.1007/s13760-021-01790-3.

    Article  PubMed  Google Scholar 

  90. Hussein M, Fathy W, Eid RA, Abdel-Hamid HM, Yehia A, Sheemy M, et al. Relative frequency and risk factors of COVID-19 related headache in a sample of egyptian population: a hospital based study. Pain Med. 2021;22:2092–9. https://doi.org/10.1093/pm/pnab020.

    Article  PubMed  Google Scholar 

  91. Ehresman JS, Bettegowda C. Treatment of oncologic emergencies in the neurocritical care unit. In: Nelson SE, Nyquist PA, editors. Neurointensive Care Unit: Clinical Practice and Organization. Chem: Humana; 2020;185–93.

    Chapter  Google Scholar 

  92. Koenig MA. Cerebral edema and elevated intracranial pressure. Continuum. 2018;24:1588–602. https://doi.org/10.1212/CON.0000000000000665.

    Article  PubMed  Google Scholar 

  93. Gentile S, Lo Giudice R, De Martino P, Rainero I, Pinessi L. Headache attributed to spontaneous low CSF pressure: report of three cases responsive to corticosteroids. Eur J Neurol. 2004;11:849–51. https://doi.org/10.1111/j.1468-1331.2004.00898.x.

    Article  CAS  PubMed  Google Scholar 

  94. Russo C, Buono V, Fenza G, Zandolino A, Serino A, Manto A. Spontaneous intracranial hypotension: two steroid-responsive cases. Pol J Radiol. 2018;83:e229–33. https://doi.org/10.5114/pjr.2018.76380.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Derry S, Wiffen PJ, Moore RA. Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2015;2015:1–28. https://doi.org/10.1002/14651858.CD011509.pub2.

    Article  Google Scholar 

  96. Paech MJ, Doherty DA, Christmas T, Wong CA. The volume of blood for epidural blood patch in obstetrics: a randomized, blinded clinical trial. Anesth Analg. 2011;113:126–33. https://doi.org/10.1213/ANE.0b013e318218204d.

    Article  PubMed  Google Scholar 

  97. Ferrante E, Arpino I, Citterio A, Wetzl R, Savino A. Epidural blood patch in Trendelenburg position pre-medicated with acetazolamide to treat spontaneous intracranial hypotension. Eur J Neurol. 2010;17:715–9. https://doi.org/10.1111/j.1468-1331.2009.02913.x.

    Article  CAS  PubMed  Google Scholar 

  98. Wu W, Hseu SS, Fuh JL, Lirng JF, Wang YF, Chen WT, et al. Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension. Brain. 2017;140:344–52. https://doi.org/10.1093/brain/aww328.

    Article  PubMed  Google Scholar 

  99. Ros B, Iglesias S, Martín Á, Carrasco A, Ibáñez G, Arráez MA. Shunt overdrainage syndrome: review of the literature. Neurosurg Rev. 2018;41:969–81. https://doi.org/10.1007/s10143-017-0849-5.

    Article  PubMed  Google Scholar 

  100. Friedman DI, Quiros PA, Subramanian PS, Mejico LJ, Gao S, McDermott M, et al. Headache in idiopathic intracranial hypertension: findings from the idiopathic intracranial hypertension treatment trial. Headache. 2017;57:1195–205. https://doi.org/10.1111/head.13153.

    Article  PubMed  PubMed Central  Google Scholar 

  101. Godoy DA, Rabinstein AA, Biestro A, Ainslie PN, Di Napoli M. Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: A feasibility study. Neurosurgery. 2012;71:245–57. https://doi.org/10.1227/NEU.0b013e318256b9f5.

    Article  PubMed  Google Scholar 

  102. Al-Mufti F, Mayer SA. Neurocritical care of acute subdural hemorrhage. Neurosurg Clin N Am. 2017;28:267–78. https://doi.org/10.1016/j.nec.2016.11.009.

    Article  PubMed  Google Scholar 

Download references

Funding

Drs. Busl and Maciel are supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number U01NS124613. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

Authors

Contributions

Dr. Pomar-Forero drafted the manuscript and Drs. Maciel, Busl, Ahmad, and Barlow provided critical revision of the manuscript.

Corresponding author

Correspondence to Carolina B. Maciel.

Ethics declarations

Disclosure

Daniela Pomar-Forero reports no relevant disclosures. Bakhtawar Ahmad reports no relevant disclosures. Brooke Barlow reports no relevant disclosures. Katharina M. Busl and Carolina B. Maciel are co-principal investigators on BLOCK-SAH study, which is a multicenter, randomized trial investigating the role of pterygopalatine fossa nerve block as a potential treatment in post-SAH headaches.

Conflict of Interest

The authors declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

We confirm that authorship requirements have been met and the final manuscript was approved by all authors. This manuscript has not been published elsewhere and is not under consideration by another journal. This article is an editorial, not using original data subjected to regulatory requirements of IRB or IACUC.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pomar-Forero, D., Ahmad, B., Barlow, B. et al. Headache Management in the Neuroscience Intensive Care Unit. Curr Pain Headache Rep (2023). https://doi.org/10.1007/s11916-023-01181-8

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11916-023-01181-8

Keywords

Navigation