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SPECT/CT Scan: A New Diagnostic Tool in Pain Medicine

  • Anesthetic Techniques in Pain Management (D Wang, Section Editor)
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Abstract

Purpose of Review

The purpose of this review is to evaluate the role of SPECT/CT in identifying facet joint arthropathy and the outcomes of interventions with SPECT/CT as an adjunct.

Recent Findings

A positive finding of facet arthropathy on SPECT/CT is associated with a higher likelihood of a unilateral procedure and a significantly more effective intervention compared with those performed on patients with facet arthropathy diagnosed only by clinical and/or radiologic examination. Surgical treatment of SPECT/CT-positive findings appears to have a good effect; however, due to limitations in the available studies, no strong conclusion can be drawn.

Summary

SPECT/CT has a good correlation identifying pain generators in chronic neck and back pain. SPECT/CT-targeted facet interventions demonstrate a higher success rate, but SPECT/CT is not recommended as a first-line diagnostic tool prior to diagnostic facet interventions. More robust studies are needed to confirm the higher success of surgical treatment for SPECT/CT-positive facet arthropathy.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Lucas JW, Connor EM, Bose J. Back, lower limb, and upper limb pain among U.S. adults, 2019. NCHS Data Brief. 2021 Jul;(415):1–8. PMID: 34473621.

  2. Satoskar SR, Goel AA, Mehta PH, Goel A. Quantitative morphometric analysis of the lumbar vertebral facets and evaluation of feasibility of lumbar spinal nerve root and spinal canal decompression using the Goel intraarticular facetal spacer distraction technique: a lumbar/cervical facet comparison. J Craniovertebr Junction Spine. 2014;5(4):157–62. https://doi.org/10.4103/0974-8237.147079.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Cohen SP, Raja SN. Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology. 2007;106(3):591–614. https://doi.org/10.1097/00000542-200703000-00024.

    Article  PubMed  Google Scholar 

  4. van Kleef M, Vanelderen P, Cohen SP, Lataster A, Van Zundert J, Mekhail N. 12. Pain originating from the lumbar facet joints. Pain Pract. 2010;10(5):459–69. https://doi.org/10.1111/j.1533-2500.2010.00393.x.

  5. Manchikanti L, Boswell MV, Singh V, Pampati V, Damron KS, Beyer CD. Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord. 2004;5:15. https://doi.org/10.1186/1471-2474-5-15.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Depalma MJ, Ketchum JM, Saullo TR. Multivariable analyses of the relationships between age, gender, and body mass index and the source of chronic low back pain. Pain Med. 2012. https://doi.org/10.1111/j.1526-4637.2012.01339.x.

    Article  PubMed  Google Scholar 

  7. Lotz JC, Fields AJ, Liebenberg EC. The role of the vertebral end plate in low back pain. Global Spine J. 2013;3(3):153–64. https://doi.org/10.1055/s-0033-1347298.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Brinjikji W, Luetmer PH, Comstock B, Bresnahan BW, Chen LE, Deyo RA, et al. Systematic literature review of imaging features of spinal degeneration in asymptomatic populations. AJNR Am J Neuroradiol. 2015;36(4):811–6. https://doi.org/10.3174/ajnr.A4173.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Helbig T, Lee CK. The lumbar facet syndrome. Spine (Phila Pa 1976). 1988;13(1):61–4. https://doi.org/10.1097/00007632-198801000-00015.

  10. Revel M, Poiraudeau S, Auleley GR, Payan C, Denke A, Nguyen M, et al. Capacity of the clinical picture to characterize low back pain relieved by facet joint anesthesia. Proposed criteria to identify patients with painful facet joints. Spine (Phila Pa 1976). 1998;23(18):1972–6; discussion 7. https://doi.org/10.1097/00007632-199809150-00011.

  11. Fairbank JC, Park WM, McCall IW, O'Brien JP. Apophyseal injection of local anesthetic as a diagnostic aid in primary low-back pain syndromes. Spine (Phila Pa 1976). 1981;6(6):598–605. https://doi.org/10.1097/00007632-198111000-00011.

  12. Manchikanti L, Pampati V, Fellows B, Bakhit CE. The diagnostic validity and therapeutic value of lumbar facet joint nerve blocks with or without adjuvant agents. Curr Rev Pain. 2000;4(5):337–44. https://doi.org/10.1007/s11916-000-0016-4.

    Article  PubMed  CAS  Google Scholar 

  13. Schwarzer AC, Aprill CN, Derby R, Fortin J, Kine G, Bogduk N. The false-positive rate of uncontrolled diagnostic blocks of the lumbar zygapophysial joints. Pain. 1994;58(2):195–200. https://doi.org/10.1016/0304-3959(94)90199-6.

    Article  PubMed  CAS  Google Scholar 

  14. Dolan AL, Ryan PJ, Arden NK, Stratton R, Wedley JR, Hamann W, et al. The value of SPECT scans in identifying back pain likely to benefit from facet joint injection. Br J Rheumatol. 1996;35(12):1269–73. https://doi.org/10.1093/rheumatology/35.12.1269.

    Article  PubMed  CAS  Google Scholar 

  15. Fujiwara A, Tamai K, Yamato M, An HS, Yoshida H, Saotome K, et al. The relationship between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study. Eur Spine J. 1999;8(5):396–401. https://doi.org/10.1007/s005860050193.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Boswell MV, Trescot AM, Datta S, Schultz DM, Hansen HC, Abdi S, et al. Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain. Pain Physician. 2007;10(1):7–111.

    PubMed  Google Scholar 

  17. Weishaupt D, Zanetti M, Boos N, Hodler J. MR imaging and CT in osteoarthritis of the lumbar facet joints. Skeletal Radiol. 1999;28(4):215–9. https://doi.org/10.1007/s002560050503.

    Article  PubMed  CAS  Google Scholar 

  18. Perez-Roman RJ, Brusko GD, Burks SS, Serafini AN, Wang MY. Use of single-photon emission computed tomography imaging for hypermetabolic facet identification in diagnosis of cervical and axial back pain. World Neurosurg. 2020;137:e487–92. https://doi.org/10.1016/j.wneu.2020.02.016.

    Article  PubMed  Google Scholar 

  19. Kanmaz B, Collier BD, Liu Y, Uzum F, Uygur G, Akansel G, et al. SPET and three-phase planar bone scintigraphy in adult patients with chronic low back pain. Nucl Med Commun. 1998;19(1):13–21. https://doi.org/10.1097/00006231-199801000-00004.

    Article  PubMed  CAS  Google Scholar 

  20. Holder LE, Machin JL, Asdourian PL, Links JM, Sexton CC. Planar and high-resolution SPECT bone imaging in the diagnosis of facet syndrome. J Nucl Med. 1995;36(1):37–44.

    PubMed  CAS  Google Scholar 

  21. Matar HE, Navalkissoor S, Berovic M, Shetty R, Garlick N, Casey ATH, et al. Is hybrid imaging (SPECT/CT) a useful adjunct in the management of suspected facet joints arthropathy? Int Orthop. 2013. https://doi.org/10.1007/s00264-013-1811-y.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Van de Kelft E, Verleye G, Van de Kelft AS, Melis K, Van Goethem J. Validation of topographic hybrid single-photon emission computerized tomography with computerized tomography scan in patients with and without nonspecific chronic low back pain. A prospective comparative study Spine J. 2017;17(10):1457–63. https://doi.org/10.1016/j.spinee.2017.05.007.

    Article  PubMed  Google Scholar 

  23. Cohen SP, Bhaskar A, Bhatia A, Buvanendran A, Deer T, Garg S, et al. Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group. Reg Anesth Pain Med. 2020;45(6):424–67. https://doi.org/10.1136/rapm-2019-101243.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Farshad-Amacker NA, Farshad M, Winklehner A, Andreisek G. MR imaging of degenerative disc disease. Eur J Radiol. 2015;84(9):1768–76. https://doi.org/10.1016/j.ejrad.2015.04.002.

    Article  PubMed  Google Scholar 

  25. Manchikanti L, Pampati S, Cash KA. Making sense of the accuracy of diagnostic lumbar facet joint nerve blocks: an assessment of the implications of 50% relief, 80% relief, single block, or controlled diagnostic blocks. Pain Physician. 2010. https://doi.org/10.36076/ppj.2010/13/133.

    Article  PubMed  Google Scholar 

  26. Russo VM, Dhawan RT, Dharmarajah N, Baudracco I, Lazzarino AI, Casey AT. Hybrid bone single photon emission computed tomography imaging in evaluation of chronic low back pain: correlation with modic changes and degenerative disc disease. World Neurosurg. 2017;104:816–23. https://doi.org/10.1016/j.wneu.2017.03.107.

    Article  PubMed  Google Scholar 

  27. Lusins JO, Cicoria AD, Goldsmith SJ. SPECT and lumbar MRI in back pain with emphasis on changes in end plates in association with disc degeneration. J Neuroimaging. 1998;8(2):78–82. https://doi.org/10.1111/jon19988278.

    Article  PubMed  CAS  Google Scholar 

  28. Harisankar CN, Mittal BR, Bhattacharya A, Singh P, Sen R. Utility of single photon emission computed tomography/computed tomography imaging in evaluation of chronic low back pain. Indian J Nucl Med. 2012;27(3):156–63. https://doi.org/10.4103/0972-3919.112720.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Lehman VT, Murphy RC, Kaufmann TJ, Diehn FE, Murthy NS, Wald JT, et al. Frequency of discordance between facet joint activity on technetium Tc99m methylene diphosphonate SPECT/CT and selection for percutaneous treatment at a large multispecialty institution. Am J Neuroradiol. 2014. https://doi.org/10.3174/ajnr.A3731.

    Article  PubMed  PubMed Central  Google Scholar 

  30. • Russo VM, Dhawan RT, Baudracco I, Dharmarajah N, Lazzarino AI, Casey AT. Hybrid bone SPECT/CT imaging in evaluation of chronic low back pain: correlation with facet joint arthropathy. World Neurosurg. 2017;107:732–8. https://doi.org/10.1016/j.wneu.2017.08.092. This study examines the correlation of SPECT/CT activity and CT in facet joint arthropathy.

  31. Ryan RJ, Gibson T, Fogelman I. The identification of spinal pathology in chronic low back pain using single photon emission computed tomography. Nucl Med Commun. 1992;13(7):497–502. https://doi.org/10.1097/00006231-199207000-00004.

    Article  PubMed  CAS  Google Scholar 

  32. Cho PG, Kim TW, Ji GY, Park SH, Yun MJ, Shin DA. Diagnostic value of single-photon emission computed tomography/computed tomography scans with Tc-99m HDP in cervicogenic headache. J Clin Med. 2020;9(2). https://doi.org/10.3390/jcm9020399.

  33. Pneumaticos SG, Chatziioannou SN, Hipp JA, Moore WH, Esses SI. Low pain: prediction of short-term outcome of facet joint injection with bone scintigraphy. Radiology. 2006. https://doi.org/10.1148/radiol.2382041930.

    Article  PubMed  Google Scholar 

  34. Freiermuth D, Kretzschmar M, Bilecen D, Schaeren S, Jacob AL, Aeschbach A, et al. Correlation of 99mTc-DPD SPECT/CT scan findings and diagnostic blockades of lumbar medial branches in patients with unspecific low back pain in a randomized-controlled trial. Pain Medicine (United States). 2015. https://doi.org/10.1111/pme.12841.

    Article  Google Scholar 

  35. Koh WU, Kim SH, Hwang BY, Choi WJ, Song JG, Suh JH, et al. Value of bone scintigraphy and single photon emission computed tomography (SPECT) in lumbar facet disease and prediction of short-term outcome of ultrasound guided medial branch block with bone SPECT. Korean J Pain. 2011. https://doi.org/10.3344/kjp.2011.24.2.81.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Lee I, Budiawan H, Moon JY, Cheon GJ, Kim YC, Paeng JC, et al. The value of SPECT/CT in localizing pain site and prediction of treatment response in patients with chronic low back pain. J Korean Med Sci. 2014;29(12):1711–6. https://doi.org/10.3346/jkms.2014.29.12.1711.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Garcia D, Sousa-Pinto B, Akinduro OO, De Biase G, Filho LM, Qu W, et al. SPECT-CT as a predictor of pain generators in patients undergoing intra-articular injections for chronic neck and back pain. World Neurosurg. 2022. https://doi.org/10.1016/j.wneu.2022.06.013.

    Article  PubMed  PubMed Central  Google Scholar 

  38. McDonald M, Cooper R, Wang MY. Use of computed tomography-single-photon emission computed tomography fusion for diagnosing painful facet arthropathy. Technical note. Neurosurg Focus. 2007 Jan 15;22(1):E2. https://doi.org/10.3171/foc.2007.22.1.2. PMID:17608336.

  39. Russo VM, Duits A, Dhawan RT, Casey AT. Joint arthropathy at the cranio-vertebral junction. Scintigraphic patterns on bone SPECT/CT. Br J Neurosurg. 2017;31(1):45–9. https://doi.org/10.1080/02688697.2016.1226254.

  40. Ravindra VM, Mazur MD, Bisson EF, Barton C, Shah LM, Dailey AT. The usefulness of single-photon emission computed tomography in defining painful upper cervical facet arthropathy. World Neurosurg. 2016. https://doi.org/10.1016/j.wneu.2016.09.012.

    Article  PubMed  Google Scholar 

  41. Tender GC, Davidson C, Shields J, Robichaux J, Park J, Crutcher CL, et al. Primary pain generator identification by CT-SPECT in patients with degenerative spinal disease. Neurosurg Focus. 2019. https://doi.org/10.3171/2019.9.FOCUS19608.

    Article  PubMed  Google Scholar 

  42. •• Brusko GD, Perez-Roman RJ, Tapamo H, Burks SS, Serafini AN, Wang MY. Preoperative SPECT imaging as a tool for surgical planning in patients with axial neck and back pain. Neurosurg Focus. 2019;47(6):E19. https://doi.org/10.3171/2019.9.FOCUS19648. This is the largest study describing patients who underwent pre-operative SPECT/CT resulting in substantial clinical improvement after spinal fusion.

    Article  PubMed  Google Scholar 

  43. Kato S, Demura S, Matsubara H, Inaki A, Shinmura K, Yokogawa N, et al. Utility of bone SPECT/CT to identify the primary cause of pain in elderly patients with degenerative lumbar spine disease. J Orthop Surg Res. 2019. https://doi.org/10.1186/s13018-019-1236-4.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Binder DS, Nampiaparampil DE. The provocative lumbar facet joint. Curr Rev Musculoskelet Med. 2009;2(1):15–24. https://doi.org/10.1007/s12178-008-9039-y.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Varlotta GP, Lefkowitz TR, Schweitzer M, Errico TJ, Spivak J, Bendo JA, et al. The lumbar facet joint: a review of current knowledge: part II: diagnosis and management. Skeletal Radiol. 2011;40(2):149–57. https://doi.org/10.1007/s00256-010-0984-3.

    Article  PubMed  Google Scholar 

  46. Kettler A, Wilke HJ. Review of existing grading systems for cervical or lumbar disc and facet joint degeneration. Eur Spine J. 2006;15(6):705–18. https://doi.org/10.1007/s00586-005-0954-y.

    Article  PubMed  Google Scholar 

  47. Demaerel P, Wilms G, Goffin J, Baert AL. Osteoarthritis of the facet joints and its role in low-back pain: evaluation with conventional tomography. J Belge Radiol. 1992;75(2):81–6.

    PubMed  CAS  Google Scholar 

  48. Watters WC III, Resnick DK, Eck JC, Ghogawala Z, Mummaneni PV, Dailey AT, et al. Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 13: injection therapies, low-back pain, and lumbar fusion. J Neurosurg Spine. 2014;21(1):79–90. https://doi.org/10.3171/2014.4.SPINE14281.

  49. Kim KY, Wang MY. Magnetic resonance image-based morphological predictors of single photon emission computed tomography-positive facet arthropathy in patients with axial back pain. Neurosurgery. 2006;59(1):147–56; discussion -56. https://doi.org/10.1227/01.NEU.0000219956.58725.6F.

  50. Lehman VT, Murphy RC, Schenck LA, Carter RE, Johnson GB, Kotsenas AL, et al. Comparison of facet joint activity on 99m TC-MDP SPECT/CT with facet joint signal change on MRI with fat suppression. Diagn Interv Radiol. 2016. https://doi.org/10.5152/dir.2015.15203.

    Article  PubMed  PubMed Central  Google Scholar 

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Pendleton, J., Ng, A. SPECT/CT Scan: A New Diagnostic Tool in Pain Medicine. Curr Pain Headache Rep 27, 729–735 (2023). https://doi.org/10.1007/s11916-023-01177-4

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