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Recent Neuroimaging Advances in the Study of Primary Headaches

  • Imaging (L Mechtler, Section Editor)
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Abstract

Neuroimaging techniques can be used to investigate both functional and structural features of the brain in patients who have primary headache disorders such as migraine or cluster headache. Improved treatments are needed for both, and this goal will likely be facilitated by a better understanding of the underlying biology. Functional imaging studies have identified regions active during attacks, as well as abnormalities that are present during the interictal period. Volumetric, surface-based morphometric, and tractography studies have revealed structural changes, although whether these represent a cause or effect of the condition remains to be determined. The development of new techniques and modalities promises to yield additional insights in the future. This article aims to review the major findings and most recent advances in neuroimaging of migraine and cluster headache.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380(9859):2163–96. doi:10.1016/S0140-6736(12)61729-2. Important study highlighting the prevalence and disability caused by migraine worldwide.

    Article  PubMed  Google Scholar 

  2. Kruit MC, Launer LJ, Ferrari MD, van Buchem MA. Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study. Brain J Neurol. 2005;128(Pt 9):2068–77. doi:10.1093/brain/awh542.

    Article  Google Scholar 

  3. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA J Am Medical Assoc. 2004;291(4):427–34. doi:10.1001/jama.291.4.427.

    Article  CAS  Google Scholar 

  4. Kurth T, Mohamed S, Maillard P, Zhu YC, Chabriat H, Mazoyer B, et al. Headache, migraine, and structural brain lesions and function: population based epidemiology of vascular ageing-MRI study. BMJ. 2011;342:c7357. doi:10.1136/bmj.c7357.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Scher AI, Gudmundsson LS, Sigurdsson S, Ghambaryan A, Aspelund T, Eiriksdottir G, et al. Migraine headache in middle age and late-life brain infarcts. JAMA J Am Medical Assoc. 2009;301(24):2563–70. doi:10.1001/jama.2009.932.

    Article  CAS  Google Scholar 

  6. Monteith T, Gardener H, Rundek T, Dong C, Yoshita M, Elkind MS, et al. Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community: the northern Manhattan study. Stroke J Cere Cir. 2014;45(6):1830–2. doi:10.1161/STROKEAHA.114.005447.

    Article  CAS  Google Scholar 

  7. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, et al. Migraine, headache, and the risk of stroke in women: a prospective study. Neurology. 2005;64(6):1020–6. doi:10.1212/01.WNL.0000154528.21485.3A.

    Article  CAS  PubMed  Google Scholar 

  8. MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, et al. Probable migraine with visual aura and risk of ischemic stroke: the stroke prevention in young women study. Stroke J Cere Cir. 2007;38(9):2438–45. doi:10.1161/STROKEAHA.107.488395.

    Article  Google Scholar 

  9. Schurks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339:b3914. doi:10.1136/bmj.b3914.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Stang PE, Carson AP, Rose KM, Mo J, Ephross SA, Shahar E, et al. Headache, cerebrovascular symptoms, and stroke: the atherosclerosis risk in communities study. Neurology. 2005;64(9):1573–7. doi:10.1212/01.WNL.0000158326.31368.04.

    Article  CAS  PubMed  Google Scholar 

  11. Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med. 2010;123(7):612–24. doi:10.1016/j.amjmed.2009.12.021.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol. 2004;61(9):1366–8. doi:10.1001/archneur.61.9.1366.

    Article  PubMed  Google Scholar 

  13. Dinia L, Bonzano L, Albano B, Finocchi C, Del Sette M, Saitta L, et al. White matter lesions progression in migraine with aura: a clinical and MRI longitudinal study. J Neuro Off J Am Soc Neuro. 2013;23(1):47–52. doi:10.1111/j.1552-6569.2011.00643.x.

    Google Scholar 

  14. Zheng Z, Xiao Z, Shi X, Ding M, Di W, Qi W, et al. White matter lesions in chronic migraine with medication overuse headache: a cross-sectional MRI study. J Neurol. 2014;261(4):784–90. doi:10.1007/s00415-014-7267-1.

    Article  CAS  PubMed  Google Scholar 

  15. Bayram E, Topcu Y, Karaoglu P, Yis U, Cakmakci Guleryuz H, Kurul SH. Incidental white matter lesions in children presenting with headache. Headache. 2013;53(6):970–6. doi:10.1111/head.12089.

    Article  PubMed  Google Scholar 

  16. Candee MS, McCandless RT, Moore KR, Arrington CB, Minich LL, Bale Jr JF. White matter lesions in children and adolescents with migraine. Pediatr Neurol. 2013;49(6):393–6. doi:10.1016/j.pediatrneurol.2013.08.025.

    Article  PubMed  Google Scholar 

  17. Eidlitz-Markus T, Zeharia A, Haimi-Cohen Y, Konen O. MRI white matter lesions in pediatric migraine. Cephalalgia Int J Headache. 2013;33(11):906–13. doi:10.1177/0333102413480955.

    Article  Google Scholar 

  18. Mar S, Kelly JE, Isbell S, Aung WY, Lenox J, Prensky A. Prevalence of white matter lesions and stroke in children with migraine. Neurology. 2013;81(16):1387–91. doi:10.1212/WNL.0b013e3182a8412e.

    Article  CAS  PubMed  Google Scholar 

  19. Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, et al. Structural brain changes in migraine. JAMA J Am Med Assoc. 2012;308(18):1889–97. doi:10.1001/jama.2012.14276. Longitudinal outcomes from a population-based imaging study of white matter changes in migraine also examining cognition.

    Article  CAS  Google Scholar 

  20. Aradi M, Schwarcz A, Perlaki G, Orsi G, Kovacs N, Trauninger A, et al. Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients. Headache. 2013;53(5):752–63. doi:10.1111/head.12013.

    Article  PubMed  Google Scholar 

  21. Hamedani AG, Rose KM, Peterlin BL, Mosley TH, Coker LH, Jack CR, et al. Migraine and white matter hyperintensities: the ARIC MRI study. Neurology. 2013;81(15):1308–13. doi:10.1212/WNL.0b013e3182a8235b.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Li XL, Fang YN, Gao QC, Lin EJ, Hu SH, Ren L, et al. A diffusion tensor magnetic resonance imaging study of corpus callosum from adult patients with migraine complicated with depressive/anxious disorder. Headache. 2011;51(2):237–45. doi:10.1111/j.1526-4610.2010.01774.x.

    Article  PubMed  Google Scholar 

  23. Yu D, Yuan K, Qin W, Zhao L, Dong M, Liu P, et al. Axonal loss of white matter in migraine without aura: a tract-based spatial statistics study. Cephalalgia Int J Headache. 2013;33(1):34–42. doi:10.1177/0333102412466964.

    Article  Google Scholar 

  24. Coppola G, Tinelli E, Lepre C, Iacovelli E, Di Lorenzo C, Di Lorenzo G, et al. Dynamic changes in thalamic microstructure of migraine without aura patients: a diffusion tensor magnetic resonance imaging study. Eur J Neurol Off J Eur Fed Neurol Soc. 2014;21(2):287–e13. doi:10.1111/ene.12296.

    CAS  Google Scholar 

  25. de Tommaso M, Ambrosini A, Brighina F, Coppola G, Perrotta A, Pierelli F, et al. Altered processing of sensory stimuli in patients with migraine. Nat Rev Neurol. 2014;10(3):144–55. doi:10.1038/nrneurol.2014.14.

    Article  PubMed  Google Scholar 

  26. Kim JH, Suh SI, Seol HY, Oh K, Seo WK, Yu SW, et al. Regional grey matter changes in patients with migraine: a voxel-based morphometry study. Cephalalgia Int J Headache. 2008;28(6):598–604. doi:10.1111/j.1468-2982.2008.01550.x.

    Article  CAS  Google Scholar 

  27. Rocca MA, Ceccarelli A, Falini A, Colombo B, Tortorella P, Bernasconi L, et al. Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study. Stroke J Cereb Cir. 2006;37(7):1765–70. doi:10.1161/01.STR.0000226589.00599.4d.

    Article  Google Scholar 

  28. Schmidt-Wilcke T, Ganssbauer S, Neuner T, Bogdahn U, May A. Subtle grey matter changes between migraine patients and healthy controls. Cephalalgia Int J Headache. 2008;28(1):1–4. doi:10.1111/j.1468-2982.2007.01428.x.

    CAS  Google Scholar 

  29. Schmitz N, Admiraal-Behloul F, Arkink EB, Kruit MC, Schoonman GG, Ferrari MD, et al. Attack frequency and disease duration as indicators for brain damage in migraine. Headache. 2008;48(7):1044–55. doi:10.1111/j.1526-4610.2008.01133.x.

    Article  PubMed  Google Scholar 

  30. Valfre W, Rainero I, Bergui M, Pinessi L. Voxel-based morphometry reveals gray matter abnormalities in migraine. Headache. 2008;48(1):109–17. doi:10.1111/j.1526-4610.2007.00723.x.

    Article  PubMed  Google Scholar 

  31. Jin C, Yuan K, Zhao L, Zhao L, Yu D, von Deneen KM, et al. Structural and functional abnormalities in migraine patients without aura. NMR Biomed. 2013;26(1):58–64. doi:10.1002/nbm.2819.

    Article  PubMed  Google Scholar 

  32. Yuan K, Zhao L, Cheng P, Yu D, Zhao L, Dong T, et al. Altered structure and resting-state functional connectivity of the basal ganglia in migraine patients without aura. J Pain Off J Am Pain Soc. 2013;14(8):836–44. doi:10.1016/j.jpain.2013.02.010.

    Article  Google Scholar 

  33. Gudmundsson LS, Scher AI, Sigurdsson S, Geerlings MI, Vidal JS, Eiriksdottir G, et al. Migraine, depression, and brain volume: the AGES-Reykjavik Study. Neurology. 2013;80(23):2138–44. doi:10.1212/WNL.0b013e318295d69e.

    Article  PubMed Central  PubMed  Google Scholar 

  34. DaSilva AF, Granziera C, Snyder J, Hadjikhani N. Thickening in the somatosensory cortex of patients with migraine. Neurology. 2007;69(21):1990–5. doi:10.1212/01.wnl.0000291618.32247.2d.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in migraine. Cephalalgia Int J Headache. 2012;32(8):607–20. doi:10.1177/0333102412445622.

    Article  Google Scholar 

  36. Granziera C, DaSilva AF, Snyder J, Tuch DS, Hadjikhani N. Anatomical alterations of the visual motion processing network in migraine with and without aura. PLoS Med. 2006;3(10):e402. doi:10.1371/journal.pmed.0030402.

    Article  PubMed Central  PubMed  Google Scholar 

  37. Datta R, Detre JA, Aguirre GK, Cucchiara B. Absence of changes in cortical thickness in patients with migraine. Cephalalgia Int J Headache. 2011;31(14):1452–8. doi:10.1177/0333102411421025.

    Article  Google Scholar 

  38. Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013;218(4):903–12. doi:10.1007/s00429-012-0437-y.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  39. Messina R, Rocca MA, Colombo B, Valsasina P, Horsfield MA, Copetti M, et al. Cortical abnormalities in patients with migraine: a surface-based analysis. Radiology. 2013;268(1):170–80. doi:10.1148/radiol.13122004.

    Article  PubMed  Google Scholar 

  40. Hansen JM, Baca SM, Vanvalkenburgh P, Charles A. Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording. Brain J Neurol. 2013;136(Pt 12):3589–95. doi:10.1093/brain/awt309.

    Article  Google Scholar 

  41. Granziera C, Daducci A, Romascano D, Roche A, Helms G, Krueger G, et al. Structural abnormalities in the thalamus of migraineurs with aura: a multiparametric study at 3 T. Hum Brain Mapp. 2014;35(4):1461–8. doi:10.1002/hbm.22266.

    Article  PubMed  Google Scholar 

  42. Schwedt TJ, Chong CD. Correlations between brain cortical thickness and cutaneous pain thresholds are atypical in adults with migraine. PLoS One. 2014;9(6):e99791. doi:10.1371/journal.pone.0099791.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Teutsch S, Herken W, Bingel U, Schoell E, May A. Changes in brain gray matter due to repetitive painful stimulation. NeuroImage. 2008;42(2):845–9. doi:10.1016/j.neuroimage.2008.05.044.

    Article  CAS  PubMed  Google Scholar 

  44. Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum. 2010;62(10):2930–40. doi:10.1002/art.27585.

    Article  PubMed  Google Scholar 

  45. Rodriguez-Raecke R, Niemeier A, Ihle K, Ruether W, May A. Structural brain changes in chronic pain reflect probably neither damage nor atrophy. PLoS One. 2013;8(2):e54475. doi:10.1371/journal.pone.0054475.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  46. Liu J, Lan L, Li G, Yan X, Nan J, Xiong S, et al. Migraine-related gray matter and white matter changes at a 1-year follow-up evaluation. J Pain Off J Am Pain Soc. 2013;14(12):1703–8. doi:10.1016/j.jpain.2013.08.013.

    Article  Google Scholar 

  47. Afridi SK, Matharu MS, Lee L, Kaube H, Friston KJ, Frackowiak RS, et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain J Neurol. 2005;128(Pt 4):932–9. doi:10.1093/brain/awh416.

    Article  CAS  Google Scholar 

  48. Denuelle M, Fabre N, Payoux P, Chollet F, Geraud G. Hypothalamic activation in spontaneous migraine attacks. Headache. 2007;47(10):1418–26. doi:10.1111/j.1526-4610.2007.00776.x.

    PubMed  Google Scholar 

  49. Weiller C, May A, Limmroth V, Juptner M, Kaube H, Schayck RV, et al. Brain stem activation in spontaneous human migraine attacks. Nat Med. 1995;1(7):658–60.

    Article  CAS  PubMed  Google Scholar 

  50. Maniyar FH, Sprenger T, Monteith T, Schankin C, Goadsby PJ. Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks. Brain J Neurol. 2014;137(Pt 1):232–41. doi:10.1093/brain/awt320.

    Article  Google Scholar 

  51. Schwedt TJ, Chong CD, Chiang CC, Baxter L, Schlaggar BL, Dodick DW. Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine. Cephalalgia : an international journal of headache. 2014. doi:10.1177/0333102414526069

  52. Schankin CJ, Maniyar FH, Sprenger T, Chou DE, Eller M, Goadsby PJ. The relation between migraine, typical migraine aura and “visual snow”. Headache. 2014;54(6):957–66. doi:10.1111/head.12378. First imaging study of “visual snow”.

    Article  PubMed  Google Scholar 

  53. Russo A, Tessitore A, Giordano A, Corbo D, Marcuccio L, De Stefano M, et al. Executive resting-state network connectivity in migraine without aura. Cephalalgia Int J Headache. 2012;32(14):1041–8. doi:10.1177/0333102412457089.

    Article  Google Scholar 

  54. Tessitore A, Russo A, Giordano A, Conte F, Corbo D, De Stefano M, et al. Disrupted default mode network connectivity in migraine without aura. J Headache Pain. 2013;14(1):89. doi:10.1186/1129-2377-14-89.

    Article  PubMed Central  PubMed  Google Scholar 

  55. Xue T, Yuan K, Zhao L, Yu D, Zhao L, Dong T, et al. Intrinsic brain network abnormalities in migraines without aura revealed in resting-state fMRI. PLoS One. 2012;7(12):e52927. doi:10.1371/journal.pone.0052927.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  56. Mainero C, Boshyan J, Hadjikhani N. Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine. Ann Neurol. 2011;70(5):838–45. doi:10.1002/ana.22537.

    Article  PubMed Central  PubMed  Google Scholar 

  57. Schwedt TJ, Larson-Prior L, Coalson RS, Nolan T, Mar S, Ances BM, et al. Allodynia and descending pain modulation in migraine: a resting state functional connectivity analysis. Pain Med. 2014;15(1):154–65. doi:10.1111/pme.12267.

    Article  PubMed Central  PubMed  Google Scholar 

  58. Schwedt TJ, Schlaggar BL, Mar S, Nolan T, Coalson RS, Nardos B, et al. Atypical resting-state functional connectivity of affective pain regions in chronic migraine. Headache. 2013;53(5):737–51. doi:10.1111/head.12081.

    Article  PubMed Central  PubMed  Google Scholar 

  59. Xue T, Yuan K, Cheng P, Zhao L, Zhao L, Yu D, et al. Alterations of regional spontaneous neuronal activity and corresponding brain circuit changes during resting state in migraine without aura. NMR Biomed. 2013;26(9):1051–8. doi:10.1002/nbm.2917.

    Article  PubMed  Google Scholar 

  60. Chanraud S, Di Scala G, Dilharreguy B, Schoenen J, Allard M, Radat F. Brain functional connectivity and morphology changes in medication-overuse headache: clue for dependence-related processes? Cephalalgia Int J Headache. 2014;34(8):605–15. doi:10.1177/0333102413519514.

    Article  CAS  Google Scholar 

  61. Hadjikhani N, Ward N, Boshyan J, Napadow V, Maeda Y, Truini A, et al. The missing link: enhanced functional connectivity between amygdala and visceroceptive cortex in migraine. Cephalalgia Int J Headache. 2013;33(15):1264–8. doi:10.1177/0333102413490344.

    Article  Google Scholar 

  62. Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain J Neurol. 2012;135(Pt 8):2546–59. doi:10.1093/brain/aws175.

    Article  Google Scholar 

  63. Moulton EA, Becerra L, Johnson A, Burstein R, Borsook D. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One. 2014;9(4):e95508. doi:10.1371/journal.pone.0095508.

    Article  PubMed Central  PubMed  Google Scholar 

  64. Yu D, Yuan K, Zhao L, Zhao L, Dong M, Liu P, et al. Regional homogeneity abnormalities in patients with interictal migraine without aura: a resting-state study. NMR Biomed. 2012;25(5):806–12. doi:10.1002/nbm.1796.

    Article  PubMed  Google Scholar 

  65. Zhao L, Liu J, Dong X, Peng Y, Yuan K, Wu F, et al. Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. J Headache Pain. 2013;14:85. doi:10.1186/1129-2377-14-85.

    Article  PubMed Central  PubMed  Google Scholar 

  66. Zhao L, Liu J, Yan X, Dun W, Yang J, Huang L, et al. Abnormal brain activity changes in patients with migraine: a short-term longitudinal study. J Clin Neurol. 2014;10(3):229–35. doi:10.3988/jcn.2014.10.3.229.

    Article  PubMed Central  PubMed  Google Scholar 

  67. Jin T, Kim SG. Characterization of non-hemodynamic functional signal measured by spin-lock fMRI. NeuroImage. 2013;78:385–95. doi:10.1016/j.neuroimage.2013.04.045.

    Article  PubMed Central  PubMed  Google Scholar 

  68. Autio JA, Shatillo A, Giniatullin R, Grohn OH. Parenchymal spin-lock fMRI signals associated with cortical spreading depression. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2014;34(5):768–75. doi:10.1038/jcbfm.2014.16.

    Article  Google Scholar 

  69. Bell IM, Gallicchio SN, Stump CA, Bruno JG, Fan H, Gantert LT, et al. [(11) C] MK-4232: the first positron emission tomography tracer for the calcitonin gene-related peptide receptor. ACS Med Chem Lett. 2013;4(9):863–8. doi:10.1021/ml400199p.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  70. May A, Ashburner J, Buchel C, McGonigle DJ, Friston KJ, Frackowiak RS, et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med. 1999;5(7):836–8. doi:10.1038/10561.

    Article  CAS  PubMed  Google Scholar 

  71. Absinta M, Rocca MA, Colombo B, Falini A, Comi G, Filippi M. Selective decreased grey matter volume of the pain-matrix network in cluster headache. Cephalalgia Int J Headache. 2012;32(2):109–15. doi:10.1177/0333102411431334.

    Article  Google Scholar 

  72. Yang FC, Chou KH, Fuh JL, Huang CC, Lirng JF, Lin YY, et al. Altered gray matter volume in the frontal pain modulation network in patients with cluster headache. Pain. 2013;154(6):801–7. doi:10.1016/j.pain.2013.02.005.

    Article  PubMed  Google Scholar 

  73. Seifert CL, Magon S, Staehle K, Zimmer C, Foerschler A, Radue EW, et al. A case-control study on cortical thickness in episodic cluster headache. Headache. 2012;52(9):1362–8. doi:10.1111/j.1526-4610.2012.02217.x.

    Article  PubMed  Google Scholar 

  74. Teepker M, Menzler K, Belke M, Heverhagen JT, Voelker M, Mylius V, et al. Diffusion tensor imaging in episodic cluster headache. Headache. 2012;52(2):274–82. doi:10.1111/j.1526-4610.2011.02000.x.

    Article  PubMed  Google Scholar 

  75. Szabo N, Kincses ZT, Pardutz A, Toth E, Szok D, Csete G, et al. White matter disintegration in cluster headache. J Headache Pain. 2013;14:64. doi:10.1186/1129-2377-14-64.

    Article  PubMed Central  PubMed  Google Scholar 

  76. Chou KH, Yang FC, Fuh JL, Huang CC, Lirng JF, Lin YY, et al. Altered white matter microstructural connectivity in cluster headaches: a longitudinal diffusion tensor imaging study. Cephalalgia Int J Headache. 2014. doi:10.1177/0333102414527649.

    Google Scholar 

  77. May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ. Hypothalamic activation in cluster headache attacks. Lancet. 1998;352(9124):275–8. doi:10.1016/S0140-6736(98)02470-2.

    Article  CAS  PubMed  Google Scholar 

  78. May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ. PET and MRA findings in cluster headache and MRA in experimental pain. Neurology. 2000;55(9):1328–35.

    Article  CAS  PubMed  Google Scholar 

  79. Morelli N, Pesaresi I, Cafforio G, Maluccio MR, Gori S, Di Salle F, et al. Functional magnetic resonance imaging in episodic cluster headache. J Headache Pain. 2009;10(1):11–4. doi:10.1007/s10194-008-0085-z.

    Article  PubMed Central  PubMed  Google Scholar 

  80. Sprenger T, Boecker H, Tolle TR, Bussone G, May A, Leone M. Specific hypothalamic activation during a spontaneous cluster headache attack. Neurology. 2004;62(3):516–7.

    Article  CAS  PubMed  Google Scholar 

  81. Sprenger T, Ruether KV, Boecker H, Valet M, Berthele A, Pfaffenrath V, et al. Altered metabolism in frontal brain circuits in cluster headache. Cephalalgia Int J Headache. 2007;27(9):1033–42. doi:10.1111/j.1468-2982.2007.01386.x.

    Article  CAS  Google Scholar 

  82. Qiu E, Wang Y, Ma L, Tian L, Liu R, Dong Z, et al. Abnormal brain functional connectivity of the hypothalamus in cluster headaches. PLoS One. 2013;8(2):e57896. doi:10.1371/journal.pone.0057896.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  83. Yang FC, Chou KH, Fuh JL, Lee PL, Lirng JF, Lin YY et al. Altered hypothalamic functional connectivity in cluster headache: a longitudinal resting-state functional MRI study. Journal of neurology, neurosurgery, and psychiatry. 2014. doi:10.1136/jnnp-2014-308122.

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Dr. Amy R. Tso and Dr. Peter J. Goadsby declare no potential conflicts of interest.

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  1. Department of Neurology, University of California San Francisco, San Francisco, CA, USA

    Amy R. Tso & Peter J. Goadsby

  2. NIHR-Wellcome Trust Clinical Research Facility, King’s College Hospital, London, SE5 9PJ, UK

    Peter J. Goadsby

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  1. Amy R. Tso
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Correspondence to Peter J. Goadsby.

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Tso, A.R., Goadsby, P.J. Recent Neuroimaging Advances in the Study of Primary Headaches. Curr Pain Headache Rep 19, 15 (2015). https://doi.org/10.1007/s11916-015-0487-y

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