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Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging

  • Bone Marrow and Adipose Tissue (B Lecka-Czernik and G Duque, Section Editors)
  • Published:
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Abstract

Purpose of Review

Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT.

Recent Findings

Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation.

Summary

This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).

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Funding

The authors are supported by funding provided by the National Institute on Aging (NIA P01 AG036675, R01 AG 067510 and T35 AG 067577).

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  1. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Husam Bensreti, Dima W. Alhamad, Alejandro Marrero Gonzalez, Manuel Pizarro-Mondesir & Meghan E. McGee-Lawrence

  2. Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Wendy B. Bollag

  3. Charlie Norwood VA Medical Center, Augusta, GA, USA

    Wendy B. Bollag

  4. Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Carlos M. Isales

  5. Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Carlos M. Isales & Meghan E. McGee-Lawrence

  6. Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Carlos M. Isales

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Bensreti, H., Alhamad, D.W., Gonzalez, A.M. et al. Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging. Curr Osteoporos Rep 21, 32–44 (2023). https://doi.org/10.1007/s11914-022-00772-5

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