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Update on Percutaneous Ablation for Sarcoma

  • REVIEW
  • Published:
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Abstract

Purpose of Review

To provide an update on the current state of percutaneous thermal ablation in the treatment of sarcoma.

Recent Findings

Data continue to accrue in support of ablation for local control and palliation of specific sarcoma subtypes such as extra-abdominal desmoid fibromatosis and for broader indications such as the treatment of oligometastatic disease. The synergistic possibilities of various combination therapies such as cryoablation and immunotherapy represent intriguing areas of active investigation. Histotripsy is an emerging non-invasive, non-thermal ablative modality that may further expand the therapeutic arsenal for sarcoma treatment.

Summary

Percutaneous thermal ablation is a valuable tool in the multidisciplinary management of sarcoma, offering a minimally invasive adjunct to surgery and radiation therapy. Although there remains a paucity of high-level evidence specific to sarcomas, ablation techniques are demonstrably safe and effective for achieving local tumor control and providing pain relief in select patients and are of particular benefit in those with metastatic disease or requiring palliative care.

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Data Availability

No datasets were generated or analysed during the current study.

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Authors and Affiliations

  1. Department of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA

    Ahmad Parvinian, Scott M. Thompson, John J. Schmitz, Brian T. Welch, Rebecca Hibbert, Daniel A. Adamo & A. Nicholas Kurup

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AP, SMT, and JJS wrote the main manuscript text. DA prepared the figure. All authors reviewed the work, edited, and approved the version to be published.

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Parvinian, A., Thompson, S.M., Schmitz, J.J. et al. Update on Percutaneous Ablation for Sarcoma. Curr Oncol Rep (2024). https://doi.org/10.1007/s11912-024-01532-7

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