Abstract
Morphologic changes in massive obesity in both humans and experiment animals are rather limited. Glomerulomegaly is common and often asymptomatic. Frequently, ensuing focal and segmental glomerulosclerosis may well be related to alterations in intraglomerular hemodynamics and may result in heavy proteinuria. Factors for the occurrence of segmental glomerulosclerosis have been assessed in animal models and include the influence of lipids. A consequence of surgical therapy for obesity (ie, jejunoileal bypass) is oxalosis with chronic interstitial nephritis, and this may necessitate a takedown of the bypass.
Similar content being viewed by others
References and Recommended Reading
Cohen AH: Massive obesity and the kidney: a morphological and statistical study. Am J Pathol 1975, 81:117–130.
Weisinger JR, Kempson RL, Eldridge FL, Swenson RS: The nephrotic syndrome: a complication of massive obesity. Ann Intern Med 1974, 81:440–447.
Jennette JC, Charles L, Grubb W: Glomerulomegaly and focal segmental glomerulosclerosis associated with obesity and sleep apnea syndrome. Am J Kidney Dis 1987, 10:470–472.
Verani RR: Obesity-associated focal segmental glomerulosclerosis: pathologic features of the lesion and relationship with cardiomegaly and hyperlipidemia. Am J Kidney Dis 1992, 20:629–634.
Warnke RA, Kempson RL: The nephrotic syndrome in massive obesity: a study by light, immunofluorescence, and electron microscopy. Arch Pathol Lab Med 1978, 102:431–438.
Hill JE, Brands MW, Henegar JR, Shek EW: Abnormal kidney function as a cause and a consequence of obesity hypertension. Clin Exp Pharmacol Physiol 1998, 25:65–69. Complete review of changes in obesity and of pathogenic mechanisms.
Dornfeld LP: Obesity. In In Massry... Glassock’s Textbook of Nephrology, ed 3. Edited by Massry SG, Glassock RJ. Baltimore: Williams and Wilkins; 1995:1128–1134.
Kasiske BL, Napier J: Glomerular sclerosis in patients with massive obesity. Am J Nephrol 1985, 5:45–50.
Wesson DE, Kurtzman NA, Frommer JP: Massive obesity and nephrotic proteinuria with a normal renal biopsy. Nephron 1985, 40:235–237.
Johnson PR, Stern JS, Horwitz BA, et al.: Longevity in obese and lean male and female rats of the Zucker strain: prevention of hyperphagia. Am J Clin Nutr 1997, 66:890–903.
Michel O, Heudes D, Lamarre I, et al.: Reduction of insulin and triglycerides delays glomerulosclerosis in obese Zucker rats. Kidney Int 1997, 52:1532–1542.
Gades MD, Stern JS, van Goor H, et al.: Estrogen accelerates the development of renal disease in female obese Zucker rats. Kidney Int 1998, 53:130–135.
Magil AB, Cohen AH: Monocytes and focal glomerulosclerosis. Lab Invest 1989, 61:404–429.
Magil AB, Frohlich JJ: Monocytes and macrophages in focal glomerulosclerosis in Zucker rats. Nephron 1991, 59:131–138.
Lavaud S, Michel O, Sassy-Prigent C, et al.: Early influx of glomerular macrophages precedes glomerulosclerosis in the obese Zucker rat model. J Am Soc Nephrol 1996, 7:2604–2615.
Requarth JA, Burchard KW, Colacchio TA, et al.: Long-term morbidity following jejunoileal bypass: the continuing potential need for surgical revision. Arch Surg 1995, 130:318–325.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cohen, A.H. Pathology of renal complications in obesity. Current Science Inc 1, 137–139 (1999). https://doi.org/10.1007/s11906-999-0008-7
Issue Date:
DOI: https://doi.org/10.1007/s11906-999-0008-7