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To Each Its Own: Linking the Biology and Epidemiology of NHL Subtypes

  • B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (J Armitage, Section Editor)
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Abstract

Non-Hodgkin lymphoma (NHL) constitutes a diverse group of more than 40 subtypes, each characterized by distinct biologic and clinical features. Until recently, pinpointing genetic and epidemiologic risk factors for individual subtypes has been limited by the relative rarity of each. However, several large pooled case-control studies have provided sufficient statistical power for detecting etiologic differences and commonalities between subtypes and thus yield new insight into their unique epidemiologic backgrounds. Here, we review the subtype-specific medical, lifestyle, and biologic components identified in these studies, which suggest that a complex interplay between host genetics, autoimmune disorders, modifiable risk factors, and occupation contributes to lymphomagenesis.

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Authors and Affiliations

  1. Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Rd NE, Building B, Suite 4302, Atlanta, GA, USA

    Jean L. Koff, Anh Phan, Jessica N. Williams & Christopher R. Flowers

  2. Department of Lymphoma/Myeloma, MD Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Unit 0429, Houston, TX, USA

    Dai Chihara & Loretta J. Nastoupil

Authors
  1. Jean L. Koff
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  2. Dai Chihara
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  3. Anh Phan
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  4. Loretta J. Nastoupil
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  5. Jessica N. Williams
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  6. Christopher R. Flowers
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Corresponding author

Correspondence to Christopher R. Flowers.

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This article is part of the Topical Collection on B-cell NHL, T-cell NHL, and Hodgkin Lymphoma

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Koff, J.L., Chihara, D., Phan, A. et al. To Each Its Own: Linking the Biology and Epidemiology of NHL Subtypes. Curr Hematol Malig Rep 10, 244–255 (2015). https://doi.org/10.1007/s11899-015-0267-0

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