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Postoperative Complications After Colorectal Surgery: Where Are We in the Era of Enhanced Recovery?

  • Large Intestine (R Chokshi, Section Editor)
  • Published:
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Abstract

Purpose of Review

Individual elements in enhanced recovery pathways may be associated with specific complication risks. In this review, we highlight three areas of controversy surrounding complications in enhanced recovery: (1) whether enhanced recovery is associated with increased rates of acute kidney injury, (2) whether NSAID use is associated with anastomotic leaks, and (3) whether early urinary catheter removal is justified following colorectal surgery.

Recent Findings

Acute kidney injury has been reported at several institutions following implementation of enhanced recovery pathways highlighting the importance of institutional data tracking. NSAID use has been implicated in anastomotic leak rates for non-elective colorectal procedures, and criteria for its use should be implemented. Early urinary catheter removal has been supported despite increased urinary retention rates in order to decrease urinary tract infections.

Summary

Enhanced recovery protocols will continue to evolve, and risk profiles associated with individual elements should continue to be evaluated.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA surgery. 2017;152(3):292–8.

    Article  PubMed  Google Scholar 

  2. Merchea A, Larson DW. Enhanced recovery after surgery and future directions. Surg Clin North Am. 2018;98(6):1287–92.

    Article  PubMed  Google Scholar 

  3. Ni X, Jia D, Chen Y, Wang L, Suo J. Is the enhanced recovery after surgery (ERAS) program effective and safe in laparoscopic colorectal cancer surgery? A meta-analysis of randomized controlled trials. J Gastrointest Surg. 2019;23(7):1502–12.

    Article  PubMed  Google Scholar 

  4. Pisarska M, Pedziwiatr M, Malczak P, Major P, Ochenduszko S, Zub-Pokrowiecka A, et al. Do we really need the full compliance with ERAS protocol in laparoscopic colorectal surgery? A prospective cohort study. Int J Surg. 2016;36(Pt A):377–82.

    Article  PubMed  Google Scholar 

  5. Wahl TS, Goss LE, Morris MS, Gullick AA, Richman JS, Kennedy GD, et al. Enhanced recovery after surgery (ERAS) eliminates racial disparities in postoperative length of stay after colorectal surgery. Ann Surg. 2018;268(6):1026–35.

    Article  PubMed  Google Scholar 

  6. Hassinger TE, Mehaffey JH, Martin AN, Bauer-Nilsen K, Turrentine FE, Thiele RH, et al. Implementation of an enhanced recovery protocol is associated with on-time initiation of adjuvant chemotherapy in colorectal Cancer. Dis Colon Rectum. 2019;62(11):1305–15.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ahmed J, Khan S, Lim M, Chandrasekaran TV, MacFie J. Enhanced recovery after surgery protocols - compliance and variations in practice during routine colorectal surgery. Color Dis. 2012;14(9):1045–51.

    Article  CAS  Google Scholar 

  8. Memtsoudis SG, Poeran J, Kehlet H. Enhanced recovery after surgery in the United States: from evidence-based practice to uncertain science? JAMA. 2019;321(11):1049–50.

    Article  PubMed  Google Scholar 

  9. Horres CR, Adam MA, Sun Z, Thacker JK, Moon RE, Miller TE, et al. Enhanced recovery protocols for colorectal surgery and postoperative renal function: a retrospective review. Perioper Med (Lond). 2017;6:13.

    Article  Google Scholar 

  10. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute Dialysis quality initiative w. acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit Care. 2004;8(4):R204–12.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4):c179–84.

    PubMed  Google Scholar 

  12. Kork F, Balzer F, Spies CD, Wernecke KD, Ginde AA, Jankowski J, et al. Minor postoperative increases of creatinine are associated with higher mortality and longer hospital length of stay in surgical patients. Anesthesiology. 2015;123(6):1301–11.

    Article  CAS  PubMed  Google Scholar 

  13. Marcotte JH, Patel K, Desai R, Gaughan JP, Rattigan D, Cahill KW, et al. Acute kidney injury following implementation of an enhanced recovery after surgery (ERAS) protocol in colorectal surgery. Int J Color Dis. 2018;33(9):1259–67.

    Article  Google Scholar 

  14. Koerner CP, Lopez-Aguiar AG, Zaidi M, Speegle S, Balch G, Shaffer VO, et al. Caution: increased acute kidney injury in enhanced recovery after surgery (ERAS) protocols. Am Surg. 2019;85(2):156–61.

    Article  PubMed  Google Scholar 

  15. Wiener JGD, Goss L, Wahl TS, Terry MA, Burge KG, Chu DI, et al. The Association of Enhanced Recovery Pathway and Acute Kidney Injury in patients undergoing colorectal surgery. Dis Colon Rectum. 2020;63(2):233–41.

    Article  PubMed  Google Scholar 

  16. Hassinger TE, Turrentine FE, Thiele RH, Sarosiek BM, McMurry TL, Friel CM, et al. Acute kidney injury in the age of enhanced recovery protocols. Dis Colon Rectum. 2018;61(8):946–54.

    Article  PubMed  PubMed Central  Google Scholar 

  17. • Hawkins AT, MD ME, Wanderer JP, Ford MM, Hopkins MB, Muldoon RL, et al. Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis. Dis Colon Rectum. 2018;61(12):1426–34 Results showing ketorlac not associated with AKI or anastomotic leak in ERP for elective colorectal surgery when restricted by protocol criteria.

    Article  PubMed  Google Scholar 

  18. Biteker M, Dayan A, Tekkesin AI, Can MM, Tayci I, Ilhan E, et al. Incidence, risk factors, and outcomes of perioperative acute kidney injury in noncardiac and nonvascular surgery. Am J Surg. 2014;207(1):53–9.

    Article  PubMed  Google Scholar 

  19. Meersch M, Schmidt C, Zarbock A. Perioperative acute kidney injury: an under-recognized problem. Anesth Analg. 2017;125(4):1223–32.

    Article  PubMed  Google Scholar 

  20. Wahl TS, Graham LA, Morris MS, Richman JS, Hollis RH, Jones CE, et al. Association between preoperative proteinuria and postoperative acute kidney injury and readmission. JAMA surgery. 2018;153(9):e182009.

    Article  PubMed  PubMed Central  Google Scholar 

  21. ACS NSQIP Participant Use Data File [Available from: https://www.facs.org/quality-programs/acs-nsqip/program-specifics/participant-use. Accessed 15 Jan 2020.

  22. Schlachta CM, Burpee SE, Fernandez C, Chan B, Mamazza J, Poulin EC. Optimizing recovery after laparoscopic colon surgery (ORAL-CS): effect of intravenous ketorolac on length of hospital stay. Surg Endosc. 2007;21(12):2212–9.

    Article  CAS  PubMed  Google Scholar 

  23. • Hakkarainen TW, Steele SR, Bastaworous A, Dellinger EP, Farrokhi E, Farjah F, et al. Nonsteroidal Anti-inflammatory Drugs and the Risk for Anastomotic Failure: A Report From Washington State's Surgical Care and Outcomes Assessment Program (SCOAP). JAMA Surg. 2015;150(3):223–8 Results from statewide colloborative showing risk of NSAIDs for anastomotic leak mainly confined to non-elective colorectal surgery.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Van Koughnett JA, Wexner SD. Surgery. NSAIDs and risk of anastomotic leaks after colorectal surgery. Nat Rev Gastroenterol Hepatol. 2014;11(9):523–4.

    Article  PubMed  Google Scholar 

  25. Gorissen KJ, Benning D, Berghmans T, Snoeijs MG, Sosef MN, Hulsewe KW, et al. Risk of anastomotic leakage with non-steroidal anti-inflammatory drugs in colorectal surgery. Br J Surg. 2012;99(5):721–7.

    Article  CAS  PubMed  Google Scholar 

  26. Klein M, Gogenur I, Rosenberg J. Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data. BMJ. 2012;345:e6166.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Subendran J, Siddiqui N, Victor JC, McLeod RS, Govindarajan A. NSAID use and anastomotic leaks following elective colorectal surgery: a matched case-control study. J Gastrointest Surg. 2014;18(8):1391–7.

    Article  PubMed  Google Scholar 

  28. Saleh F, Jackson TD, Ambrosini L, Gnanasegaram JJ, Kwong J, Quereshy F, et al. Perioperative nonselective non-steroidal anti-inflammatory drugs are not associated with anastomotic leakage after colorectal surgery. J Gastrointest Surg. 2014;18(8):1398–404.

    Article  PubMed  Google Scholar 

  29. Paulasir S, Kaoutzanis C, Welch KB, Vandewarker JF, Krapohl G, Lampman RM, et al. Nonsteroidal anti-inflammatory drugs: do they increase the risk of anastomotic leaks following colorectal operations? Dis Colon Rectum. 2015;58(9):870–7.

    Article  PubMed  Google Scholar 

  30. Kotagal M, Hakkarainen TW, Simianu VV, Beck SJ, Alfonso-Cristancho R, Flum DR. Ketorolac use and postoperative complications in gastrointestinal surgery. Ann Surg. 2016;263(1):71–5.

    Article  PubMed  Google Scholar 

  31. Huang Y, Tang SR, Young CJ. Nonsteroidal anti-inflammatory drugs and anastomotic dehiscence after colorectal surgery: a meta-analysis. ANZ J Surg. 2018;88(10):959–65.

    Article  PubMed  Google Scholar 

  32. Benoist S, Panis Y, Denet C, Mauvais F, Mariani P, Valleur P. Optimal duration of urinary drainage after rectal resection: a randomized controlled trial. Surgery. 1999;125(2):135–41.

    Article  CAS  PubMed  Google Scholar 

  33. Kwaan MR, Lee JT, Rothenberger DA, Melton GB, Madoff RD. Early removal of urinary catheters after rectal surgery is associated with increased urinary retention. Dis Colon Rectum. 2015;58(4):401–5.

    Article  PubMed  Google Scholar 

  34. Okrainec A, Aarts MA, Conn LG, McCluskey S, McKenzie M, Pearsall EA, et al. Compliance with urinary catheter removal guidelines leads to improved outcome in enhanced recovery after surgery patients. J Gastrointest Surg. 2017;21(8):1309–17.

    Article  PubMed  Google Scholar 

  35. Grass F, Slieker J, Frauche P, Sola J, Blanc C, Demartines N, et al. Postoperative urinary retention in colorectal surgery within an enhanced recovery pathway. J Surg Res. 2017;207:70–6.

    Article  PubMed  Google Scholar 

  36. Ghuman A, Kasteel N, Karimuddin AA, Brown CJ, Raval MJ, Phang PT. Urinary retention in early urinary catheter removal after colorectal surgery. Am J Surg. 2018;215(5):949–52.

    Article  PubMed  Google Scholar 

  37. Schreiber A, Aydil E, Walschus U, Glitsch A, Patrzyk M, Heidecke CD, et al. Early removal of urinary drainage in patients receiving epidural analgesia after colorectal surgery within an ERAS protocol is feasible. Langenbeck's Arch Surg. 2019;404(7):853–63.

    Article  Google Scholar 

  38. Zmora O, Madbouly K, Tulchinsky H, Hussein A, Khaikin M. Urinary bladder catheter drainage following pelvic surgery--is it necessary for that long? Dis Colon Rectum. 2010;53(3):321–6.

    Article  PubMed  Google Scholar 

  39. Rosen DR, Wolfe RC, Damle A, Atallah C, Chapman WC Jr, Vetter JM, et al. Thoracic epidural analgesia: does it enhance recovery? Dis Colon Rectum. 2018;61(12):1403–9.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Wiener JG, Gunnells D, Wood L, Chu DI, Cannon J, Kennedy GD, et al. Early removal of catheters in an enhanced recovery pathway (ERP) with intrathecal opioid injection does not affect postoperative urinary outcomes. Am J Surg. 2019. https://doi.org/10.1016/j.amjsurg.2019.09.023.

  41. • Patel DN, Felder SI, Luu M, Daskivich TJ, NZ K, Fleshner P. Early Urinary Catheter Removal Following Pelvic Colorectal Surgery: A Prospective, Randomized, Noninferiority Trial. Dis Colon Rectum. 2018;61(10):1180–6 Randomized non-inferiority trial showing early catheter removal in pelvic surgery is not inferior to delayed removal.

    Article  PubMed  Google Scholar 

  42. Lee Y, McKechnie T, Springer JE, Doumouras AG, Hong D, Eskicioglu C. Optimal timing of urinary catheter removal following pelvic colorectal surgery: a systematic review and meta-analysis. Int J Color Dis. 2019;34(12):2011–21.

    Article  Google Scholar 

  43. Carmichael JC, Keller DS, Baldini G, Bordeianou L, Weiss E, Lee L, et al. Clinical practice guidelines for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons. Dis Colon Rectum. 2017;60(8):761–84.

    Article  PubMed  Google Scholar 

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Correspondence to Gregory D. Kennedy.

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Hollis, R.H., Kennedy, G.D. Postoperative Complications After Colorectal Surgery: Where Are We in the Era of Enhanced Recovery?. Curr Gastroenterol Rep 22, 26 (2020). https://doi.org/10.1007/s11894-020-00763-5

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