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Recent Advances in Functional Anorectal Disorders

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Abstract

Defecatory disorders are a common cause of chronic constipation and should be managed by biofeedback-guided pelvic floor retraining. While anorectal tests are necessary to diagnose defecatory disorders, recent studies highlight the utility of a careful digital rectal examination. While obstetric anal injury can cause fecal incontinence (FI), diarrhea is a more important risk factor for FI among women in the community, who typically develop FI after age 40. Initial management of fecal incontinence should focus on bowel disturbances. Pelvic floor retraining with biofeedback therapy is beneficial for patients who do not respond to bowel management. Sacral nerve stimulation should be considered in patients who do not respond to conservative therapy.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Bharucha AE, Zinsmeister AR, Locke GR, et al. Prevalence and burden of fecal incontinence: a population based study in women. Gastroenterology. 2005;129:42–9.

    Article  PubMed  Google Scholar 

  2. Bharucha AE, Wald A, Enck P, Rao S. Functional anorectal disorders. Gastroenterology. 2006;130(5):1510–8.

    Article  PubMed  Google Scholar 

  3. Bharucha AE, Wald AM. Anorectal disorders. Am J Gastroenterol. 2010;105(4):786–94.

    Article  PubMed  Google Scholar 

  4. Ravi K, Bharucha AE, Camilleri M, et al. Phenotypic Variation Of Colonic Motor Functions In Chronic Constipation. Gastroenterology. 2009;138(1):89–97.

    Article  PubMed  Google Scholar 

  5. Suttor VP, Prott GM, Hansen RD, et al. Evidence for pelvic floor dyssynergia in patients with irritable bowel syndrome. Dis Colon Rectum. 2010;53(2):156–60.

    Article  PubMed  CAS  Google Scholar 

  6. Klingele CJ, Lightner DJ, Fletcher JG, et al. Dysfunctional urinary voiding in women with functional defecatory disorders. Neurogastroenterol Motil. 2010;22:1094–e1284.

    Article  PubMed  CAS  Google Scholar 

  7. • Whitehead WE, Bharucha AE. Diagnosis and treatment of pelvic floor disorders: what’s new and what to do. Gastroenterology. 2010;138(4):1231–1235. This review highlights major advances in pelvic floor disorders.

    Article  PubMed  Google Scholar 

  8. Lawrentschuk N, Bolton DM. Experience and attitudes of final-year medical students to digital rectal examination. Med J Aust. 2004;181(6):323–5.

    PubMed  Google Scholar 

  9. •• Orkin BA, Sinykin SB, Lloyd PC. The digital rectal examination scoring system (DRESS). Dis Colon Rectum. 2010;53(12):1656–1660. Provides a standardized scoring system for digital rectal examination and evaluates its utility in clinical practice.

    Article  PubMed  Google Scholar 

  10. •• Tantiphlachiva K, Rao P, Attaluri A, Rao SSC. Digital rectal examination is a useful tool for identifying patients with dyssynergia. Clin Gastroenterol Hepatol. 2010;8(11):955–960. Highlights the utility of a digital rectal examination for detecting dyssynergia in defecatory disorders.

    Article  PubMed  Google Scholar 

  11. Minguez M, Herreros B, Sanchiz V, et al. Predictive value of the balloon expulsion test for excluding the diagnosis of pelvic floor dyssynergia in constipation. Gastroenterology. 2004;126(1):57–62.

    Article  PubMed  Google Scholar 

  12. Fox JC, Fletcher JG, Zinsmeister AR, et al. Effect of aging on anorectal and pelvic floor functions in females. [erratum appears in Dis Colon Rectum. 2007 Mar;50(3):404]. Dis Colon Rectum. Nov 2006;49(11):1726–1735.

  13. Fernando RJ, Sultan AHH, Kettle C, et al. Methods of repair for obstetric anal sphincter injury. Cochrane Database Syst Rev. 2006;(3). doi:10.1002/14651858.CD002866.pub2.

  14. • Hale DS. Anal sphincter laceration: overlapping or end-to-end repair? Obstet Gynecol. 2010;116(1):2–3. A crisp editorial summarizing various anal sphincter repair procedures.

    Article  PubMed  Google Scholar 

  15. Farrell SA, Gilmour D, Turnbull GK, et al. Overlapping compared with end-to-end repair of third- and fourth-degree obstetric anal sphincter tears: a randomized controlled trial. Obstet Gynecol. 2010;116(1):16–24.

    Article  PubMed  Google Scholar 

  16. • Nordenstam JF, Altman DH, Mellgren AF, et al. Impaired rectal sensation at anal manometry is associated with anal incontinence one year after primary sphincter repair in primiparous women. Dis Colon Rectum. 2010;53(10):1409–1414. A large prospective study evaluating the risk factors for postpartum fecal incontinence.

    Article  PubMed  Google Scholar 

  17. Nordenstam J, Mellgren A, Altman D, et al. Immediate or delayed repair of obstetric anal sphincter tears-a randomised controlled trial. BJOG Int J Obstet Gynaecology. 2008;115(7):857–65.

    Article  CAS  Google Scholar 

  18. Bharucha AE, Fletcher JG, Harper CM, et al. Relationship between symptoms and disordered continence mechanisms in women with idiopathic fecal incontinence. Gut. 2005;54:546–55.

    Article  PubMed  CAS  Google Scholar 

  19. Gladman MA, Lunniss PJ, Scott SM, Swash M. Rectal hyposensitivity. Am J Gastroenterol. 2006;101(5):1140–51.

    Article  PubMed  Google Scholar 

  20. Kalantar JS, Howell S, Talley NJ. Prevalence of faecal incontinence and associated risk factors; an underdiagnosed problem in the Australian community? Med J Aust. 2002;176(2):54–7.

    PubMed  Google Scholar 

  21. Melville JL, Fan MY, Newton K, Fenner D. Fecal incontinence in US women: a population-based study. Am J Obstet Gynecol. 2005;193(6):2071–6.

    Article  PubMed  Google Scholar 

  22. Quander CR, Morris MC, Melson J, et al. Prevalence of and factors associated with fecal incontinence in a large community study of older individuals. Am J Gastroenterol. 2005;100(4):905–9.

    Article  PubMed  Google Scholar 

  23. Bharucha AE, Zinsmeister AR, Locke GR, et al. Risk factors for fecal incontinence: a population based study in women. Am J Gastroenterol. 2006;101:1305–12.

    Article  PubMed  Google Scholar 

  24. Whitehead WE, Borrud L, Goode PS, et al. Fecal incontinence in US adults: epidemiology and risk factors. Gastroenterology. 2009;137(2):512–7.

    Article  PubMed  Google Scholar 

  25. Rey E, Choung RS, Schleck CD, et al. Onset and risk factors for fecal incontinence in a US community. Am J Gastroenterol. 2010;105(2):412–9.

    Article  PubMed  Google Scholar 

  26. Landefeld CS, Bowers BJ, Feld AD, et al. National Institutes of Health state-of-the-science conference statement: prevention of fecal and urinary incontinence in adults. Ann Intern Med. 2008;148(6):449–58.

    PubMed  Google Scholar 

  27. Bharucha AE, Zinsmeister AR, Schleck CD, Melton 3rd LJ. Bowel disturbances are the most important risk factors for late onset fecal incontinence: a population-based case-control study in women. Gastroenterology. 2010;139(5):1559–66.

    Article  PubMed  Google Scholar 

  28. Roberson EN, Gould JC, Wald A. Urinary and fecal incontinence after bariatric surgery. Dig Dis Sci. 2010;55(9):2606–13.

    Article  PubMed  Google Scholar 

  29. • Bharucha AE. Incontinence - an underappreciated problem in obesity and bariatric surgery. Dig Dis Sci. 2010;55(9):2428–2430. A review of the e[idemiology, mechanisms, and management of fecal incontinence after bariatric surgery.

    Article  PubMed  Google Scholar 

  30. Colquitt JL, Picot J, Loveman E, Clegg AJ. Surgery for obesity. Cochrane Database Syst Rev. 2009;(2). doi:10.1002/14651858.CD003641.pub3.

  31. Heymen S, Scarlett Y, Jones K, et al. Randomized controlled trial shows biofeedback to be superior to alternative treatments for fecal incontinence. Dis Colon Rectum. 2009;52:1730–7.

    Article  PubMed  Google Scholar 

  32. Andrews C, Bharucha AE, Camilleri M, et al. Rectal sensorimotor dysfunction in women with fecal incontinence. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G282–289.

    Article  PubMed  CAS  Google Scholar 

  33. Bharucha AE, Seide BM, Zinsmeister AR. The effects of clonidine on symptoms and anorectal sensorimotor function in women with faecal incontinence. Aliment Pharmacol Ther. 2010;32(5):681–8.

    PubMed  CAS  Google Scholar 

  34. Schwandner T, Konig IR, Heimerl T, et al. Triple target treatment (3T) is more effective than biofeedback alone for anal incontinence: the 3T-AI study. Dis Colon Rectum. 2010;53(7):1007–16.

    Article  PubMed  Google Scholar 

  35. Mowatt G, Glazener C, Jarrett M. Sacral nerve stimulation for fecal incontinence and constipation in adults: a short version Cochrane review. Neurourology & Urodynamics. 2008;27(3):155–161

    Article  CAS  Google Scholar 

  36. Tjandra JJ, Chan MKY, Yeh CH, Murray-Green C. Sacral nerve stimulation is more effective than optimal medical therapy for severe fecal incontinence: a randomized, controlled study. Diseases of the Colon & Rectum. May 2008;51(5):494–502.

    Google Scholar 

  37. •• Wexner SD, Coller JA, Devroede G, et al. Sacral nerve stimulation for fecal incontinence: results of a 120-patient prospective multicenter study. Ann Surg. 2010;251(3):441–449. A large prospective study demonstrating the efficacy of sacral nerve stimulation for fecal incontinence.

    Article  PubMed  Google Scholar 

  38. Ruiz D, Pinto RA, Hull TL, et al. Does the radiofrequency procedure for fecal incontinence improve quality of life and incontinence at 1-year follow-up? Dis Colon Rectum. 2010;53(7):1041–6.

    Article  PubMed  Google Scholar 

  39. Michelsen HB, Worsoe J, Krogh K, et al. Rectal motility after sacral nerve stimulation for faecal incontinence. Neurogastroenterol Motil. 2010;22(1):36–41.

    PubMed  CAS  Google Scholar 

  40. Graf W, Mellgren A, Matzel KE, et al. Efficacy of dextranomer in stabilised hyaluronic acid for treatment of faecal incontinence: a randomised, sham-controlled trial. Lancet. 2011;377(9770):997–1003.

    Article  PubMed  CAS  Google Scholar 

  41. • Norton C. Treating faecal incontinence with bulking-agent injections. Lancet. 2011;377(9770):971–972. An editorial comment on the effect of perianal bulking injections for fecal incontinence.

    Article  PubMed  Google Scholar 

  42. Maeda Y, Laurberg S, Norton C. Perianal injectable bulking agents as treatment for faecal incontinence in adults. Cochrane Database Syst Rev. 2010(5). doi:10.1002/14651858.CD007959.pub2

  43. Bharucha AE, Fletcher JG. Recent advances in assessing anorectal structure and functions. Gastroenterology. 2007;133(4):1069–74.

    Article  PubMed  Google Scholar 

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Acknowledgments

This study was supported in part by RO1 DK 78924 from the National Institutes of Health.

Disclosure

A. Bharucha: Consultancy and patents for Medspira, Inc.

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Correspondence to Adil E. Bharucha.

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Bharucha, A.E. Recent Advances in Functional Anorectal Disorders. Curr Gastroenterol Rep 13, 316–322 (2011). https://doi.org/10.1007/s11894-011-0194-8

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