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Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review

  • Pathogenesis of Type 2 Diabetes and Insulin Resistance (M-E Patti, Section Editor)
  • Published:
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Abstract

Purpose of review

Insulin resistance (IR) is recognized to play an important role in the pathogenesis of dyslipidemia. This review summarizes the complex interplay between IR and dyslipidemia in people with and without diabetes.

Recent findings

IR impacts the metabolism of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) by several mechanisms. Trials with insulin sensitizing therapies, including biguanides and thiazolidinediones, have provided inconsistent results on lipid lowering in people with and without diabetes. In this review, we focus on the pathophysiological interplay between IR and dyslipidemia and recapitulate lipid and lipoprotein data from insulin-sensitizing trials.

Summary

Further research elucidating the reciprocal relationship between IR and dyslipidemia is needed to better target these important risk factors for cardiovascular disease.

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Funding

P.B. receives salary support by NIH (K23 DK116720-01), in addition to research support from Thrasher Research Fund, Juvenile Diabetes Research Foundation (JDRF), International Society of Pediatric and Adolescent Diabetes (ISPAD), Colorado Clinical and Translational Sciences Institute and Center for Women’s Health Research at University of Colorado. R.H.E. is supported by NIH (R21NS102506; P30DK48520; P50HD073063) a grant from ENDECE LLC. The authors were fully responsible for all content and editorial decisions, were involved at all stages of manuscript development, and have approved the final version.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Endocrinology, University of Colorado School of Medicine, 13123 East 16th Ave, Box B26, Aurora, CO, 80045, USA

    Petter Bjornstad

  2. Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO, USA

    Petter Bjornstad

  3. Department of Medicine, Division of Endocrinology and Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA

    Robert H. Eckel

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  1. Petter Bjornstad
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PB and RHE wrote, contributed to discussion, and reviewed/edited the manuscript.

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Correspondence to Petter Bjornstad or Robert H. Eckel.

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Conflict of Interest

P.B. has received speaking honoraria and research operating funding from Horizon Pharmaceuticals, and travel support from Boehringer Ingelheim.

R.H.E. serves on advisory boards for Regeneron/Sanofi, Kowa, Merck, and Novo Nordisk.

Human and Animal Rights and Informed Consent

This is a review paper and summarizes existing data. It does not contain any unpublished data in human or animal subjects performed by either of the authors.

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This article is part of the Topical Collection on Pathogenesis of Type 2 Diabetes and Insulin Resistance

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Bjornstad, P., Eckel, R.H. Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review. Curr Diab Rep 18, 127 (2018). https://doi.org/10.1007/s11892-018-1101-6

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