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Understanding Pancreas Development for β-Cell Repair and Replacement Therapies

  • Pathogenesis of Type 1 Diabetes (AG Ziegler, Section Editor)
  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

An Erratum to this article was published on 31 July 2012

Abstract

The lack or dysfunction of insulin-producing β-cells is the cause of all forms of diabetes. In vitro generation of β-cells from pluripotent stem cells for cell-replacement therapy or triggering endogenous mechanisms of β-cell repair have great potential in the field of regenerative medicine. Both approaches rely on a thorough understanding of β-cell development and homeostasis. Here, we briefly summarize the current knowledge of β-cell differentiation during pancreas development in the mouse. Furthermore, we describe how this knowledge is translated to instruct differentiation of both mouse and human pluripotent stem cells towards the β-cell lineage. Finally, we shortly summarize the current efforts to identify stem or progenitor cells in the adult pancreatic organ and to harness the endogenous regenerative potential. Understanding development and regeneration of β-cells already led to identification of molecular targets for therapy and informed on pathomechanisms of diabetes. In the future might lead to β-cell repair and replacement therapies.

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  1. Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764, Neuherberg, Germany

    Aurelia Raducanu & Heiko Lickert

  2. Institute of Stem Cell Research, Helmholtz Zentrum München, 85764, Neuherberg, Germany

    Heiko Lickert

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  1. Aurelia Raducanu
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Raducanu, A., Lickert, H. Understanding Pancreas Development for β-Cell Repair and Replacement Therapies. Curr Diab Rep 12, 481–489 (2012). https://doi.org/10.1007/s11892-012-0301-8

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