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The Role of Hyaluronan and the Extracellular Matrix in Islet Inflammation and Immune Regulation

  • Pathogenesis of Type 1 Diabetes (AG Ziegler, Section Editor)
  • Published:
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Abstract

Type 1 diabetes (T1D) is a disease that in most individuals results from autoimmune attack of a single tissue type, the pancreatic islet. A fundamental, unanswered question in T1D pathogenesis is how the islet tissue environment influences immune regulation. This crosstalk is likely to be communicated through the extracellular matrix (ECM). Here, we review what is known about the ECM in insulitis and examine how the tissue environment is synchronized with immune regulation. In particular, we focus on the role of hyaluronan (HA) and its interactions with Foxp3+ regulatory T-cells (Treg). We propose that HA is a “keystone molecule” in the inflammatory milieu and that HA, together with its associated binding proteins and receptors, is an appropriate point of entry for investigations into how ECM influences immune regulation in the islet.

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Acknowledgments

This work was supported by National Institutes of Health grants DK046635 (to G.T.N.); DK080178, DK089128 and U01AI101984 (to P.L.B.); and HL018645 and a BIRT supplement AR037296 (to T.N.W.). This work was also supported by grants from the Juvenile Diabetes Research Foundation (nPOD 25-2010-648 (to T.N.W.), and The Center for Translational Research at BRI (to G.T.N.).

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Authors and Affiliations

  1. Benaroya Research Institute at Virginia Mason, 1201 9th Ave, Seattle, WA, 98101, USA

    Paul L. Bollyky, Jennifer B. Bollyky & Thomas N. Wight

  2. Pacific Northwest Diabetes Research Institute, 720 Broadway, Seattle, WA, USA

    Marika Bogdani

  3. Division of Metabolism, Endocrinology, and Nutrition, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA

    Rebecca L. Hull

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  1. Paul L. Bollyky
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Correspondence to Paul L. Bollyky.

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Bollyky, P.L., Bogdani, M., Bollyky, J.B. et al. The Role of Hyaluronan and the Extracellular Matrix in Islet Inflammation and Immune Regulation. Curr Diab Rep 12, 471–480 (2012). https://doi.org/10.1007/s11892-012-0297-0

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  • DOI: https://doi.org/10.1007/s11892-012-0297-0

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