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The Potential Role of PET in the Management of Peripheral Artery Disease

  • Nuclear Cardiology (V Dilsizian, Section Editor)
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Abstract

Purpose of Review

Current non-invasive tests for evaluating patients with peripheral artery disease (PAD) have significant limitations for early detection and management of patients with PAD and are generally focused on the evaluation of large vessel disease. PAD often involves disease of microcirculation and altered metabolism. Therefore, there is a critical need for reliable quantitative non-invasive tools that can assess limb microvascular perfusion and function in the setting of PAD.

Recent Findings

Recent developments in positron emission tomography (PET) imaging have enabled the quantification of blood flow to the lower extremities, the assessment of the viability of skeletal muscles, and the evaluation of vascular inflammation and microcalcification and angiogenesis in the lower extremities. These unique capabilities differentiate PET imaging from current routine screening and imaging methods.

Summary

The purpose of this review is to highlight the promising role of PET in the early detection and management of PAD providing a summary of the current preclinical and clinical research related to PET imaging in patients with PAD and related advancement of PET scanner technology.

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    Funding

    Alaa Alashi and Billy C. Vermillion report an NIH training grant (NIH-NRSA T32:HL 098069). Albert J. Sinusas reports NIH funding related to this article (R01 HL163640).

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    1. Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, P.O. Box 208017, DANA 3, New Haven, CT, 06520-8017, USA

      Alaa Alashi, Billy C. Vermillion & Albert J. Sinusas

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    Albert J. Sinusas reports Institutional grants from Jubilant and Siemens; individual consulting fees unrelated to PET imaging compounds from MicroVide, LLC; patents related to SPECT imaging agent RP805 for MicroVide, LLC; member Cardiovascular Council of SNMMI (no funds received); receipt of equipment, materials, drugs, or other services from Lantheus (MTA LMI1195) and Jubilant (Rb-82 generator). The other authors declare that they have no conflict of interest.

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    Alashi, A., Vermillion, B.C. & Sinusas, A.J. The Potential Role of PET in the Management of Peripheral Artery Disease. Curr Cardiol Rep 25, 831–839 (2023). https://doi.org/10.1007/s11886-023-01904-8

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