Abstract
Purpose of Review
To summarize the prevalence, correlates, and health consequences of poor mental health in the increasingly sizable population of survivors of Sudden cardiac arrest (CA) and to describe current intervention research in this area.
Recent Findings
After CA many patients report high psychological distress, including depression, generalized anxiety, and posttraumatic stress. Emerging evidence suggests that distressed patients’ attention may narrow such that anxious awareness of afferent cardiac signals e.g., changes in heart rate or blood pressure, becomes predominant and a cause for concerned, constant monitoring. This cardiac-specific anxiety followed by behavioral avoidance and physiological hyperreactivity may increase patients’ already high risk of secondary cardiovascular disease and undermine their health-related quality of life (HRQoL).
Summary
Unlike other cardiovascular diseases, no clinical practice guidelines exist for assessing or treating psychological sequelae of CA. Future research should identify modifiable psychological targets to reduce secondary cardiovascular disease risk and improve HRQoL.
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References
Papers of particular interest, published recently, have been highlighted as:
•• Of major importance
Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135:e146–603.
•• Sawyer KN, Camp-Rogers TR, Kotini-Shah P, et al. Sudden cardiac arrest survivorship: a scientific statement from the American Heart Association. Circulation. 2020;141:e654–85. Findings from this scientific statement acknowledge the gaps in provision of resources and scientific studies on recovery, survivorship, and rehabilitation.
Stecker EC, Reinier K, Marijon E, et al. Public health burden of sudden cardiac death in the United States. Circ Arrhythm Electrophysiol. 2014;7:212–7.
•• Agarwal S, Presciutti A, Cornelius T, et al. Cardiac arrest and subsequent hospitalization-induced posttraumatic stress is associated with 1 year risk of major adverse cardiovascular events and all-cause mortality. Crit Care Med. 2019;47:e502–5. Findings from this study suggest that PTSD symptoms are highly prevalent after cardiac arrest and are associated with higher likelihood of major cardiovascular events and death at 1 year.
Haydon G, van der Riet P, Inder K. A systematic review and meta-synthesis of the qualitative literature exploring the experiences and quality of life of survivors of a cardiac arrest. Eur J Cardiovasc Nurs. 2017;16:475–83.
Sawyer KN, Brown F, Christensen R, Damino C, Newman MM, Kurz MC. Surviving sudden cardiac arrest: a pilot qualitative survey study of survivors. Ther Hypothermia Temp Manag. 2016;6:76–84.
Ketilsdottir A, Albertsdottir HR, Akadottir SH, Gunnarsdottir TJ, Jonsdottir H. The experience of sudden cardiac arrest: becoming reawakened to life. Eur J Cardiovasc Nurs. 2014;13:429–35.
Forslund A-S, Zingmark K, Jansson J-H, Lundblad D, Söderberg S. Meanings of people’s lived experiences of surviving an out-of-hospital cardiac arrest, 1 month after the event. J Cardiovasc Nurs. 2014;29:464–71.
Larsson IM, Wallin E, Rubertsson S, Kristofferzon ML. Health-related quality of life improves during the first six months after cardiac arrest and hypothermia treatment. Resuscitation. 2014;85:215–20.
Wachelder EM, Moulaert VR, van Heugten C, Verbunt JA, Bekkers SC, Wade DT. Life after survival: long-term daily functioning and quality of life after an out-of-hospital cardiac arrest. Resuscitation. 2009;80:517–22.
Bunch TJ, White RD, Khan AH, Packer DL. Impact of age on long-term survival and quality of life following out-of-hospital cardiac arrest. Crit Care Med. 2004;32:963–7.
Granja C, Cabral G, Pinto AT, Costa-Pereira A. Quality of life 6 months after cardiac arrest. Resuscitation. 2002;55:37–44.
O’Reilly SM, Grubb N, O’Carroll RE. Long-term emotional consequences of in-hospital cardiac arrest and myocardial infarction. Br J Clin Psychol. 2004;43:83–95.
Wilson M, Staniforth A, Till R, das Nair R, Vesey P. The psychosocial outcomes of anoxic brain injury following cardiac arrest. Resuscitation 2014;85:795–800.
Moulaert VRM, van Heugten CM, Gorgels TPM, Wade DT, Verbunt JA. Long-term outcome after survival of a cardiac arrest: a prospective longitudinal cohort study. Neurorehabil Neural Repair. 2017;31:530–9.
Gander ML, von Kanel R. Myocardial infarction and post-traumatic stress disorder: frequency, outcome, and atherosclerotic mechanisms. Eur J Cardiovasc Prev Rehabil. 2006;13:165–72.
Copland C, Joekes K, Ayers S. Anxiety and post-traumatic stress disorder in cardiac patients. Br J Wellbeing. 2011;2:21–5.
Edmondson D, Falzon L, Sundquist KJ, et al. A systematic review of the inclusion of mechanisms of action in NIH-funded intervention trials to improve medication adherence. Behav Res Ther. 2018;101:12–9.
Gamper G, Willeit M, Sterz F, et al. Life after death: posttraumatic stress disorder in survivors of cardiac arrest–prevalence, associated factors, and the influence of sedation and analgesia. Crit Care Med. 2004;32:378–83.
Presciutti A, Frers A, Sumner JA, et al. Dimensional structure of posttraumatic stress disorder symptoms after cardiac arrest. J Affect Disord. 2019;251:213–7.
Presciutti A, Verma J, Pavol M, et al. Posttraumatic stress and depressive symptoms characterize cardiac arrest survivors’ perceived recovery at hospital discharge. Gen Hosp Psychiatry. 2018;53:108–13.
Presciutti A, Sobczak E, Sumner JA, et al. The impact of psychological distress on long-term recovery perceptions in survivors of cardiac arrest. J Crit Care. 2019;50:227–33.
Rosman L, Whited A, Lampert R, Mosesso VN, Lawless C, Sears SF. Cardiac anxiety after sudden cardiac arrest: severity, predictors and clinical implications. Int J Cardiol. 2015;181:73–6.
van Beek MH, Voshaar RC, van Deelen FM, van Balkom AJ, Pop G, Speckens AE. The cardiac anxiety questionnaire: cross-validation among cardiac inpatients. Int J Psychiatry Med. 2012;43(4):349–64.
Hamang A, Eide GE, Rokne B, Nordin K, Øyen N. General anxiety, depression, and physical health in relation to symptoms of heart-focused anxiety- a cross sectional study among patients living with the risk of serious arrhythmias and sudden cardiac death. Health Qual Life Outcomes. 2011;9:100.
Marker CD, Carmin CN, Ownby RL. Cardiac anxiety in people with and without coronary atherosclerosis. Depress Anxiety. 2008;25:824–31.
Spinhoven P, Van der Does AJW, Van Dijk E, Van Rood YR. Heart-focused anxiety as a mediating variable in the treatment of noncardiac chest pain by cognitive-behavioral therapy and paroxetine. J Psychosom Res. 2010;69:227–35.
Hoyer J, Eifert GH, Einsle F, et al. Heart-focused anxiety before and after cardiac surgery. J Psychosom Res. 2008;64:291–7.
Characterize psychological and behavioral dimensions of cardiac arrest survivorship, and their association with 1-year mortality, cardiovascular disease risk and health-related quality of life. Grantome, 2020. Accessed 11 May 2022, at https://grantome.com/grant/NIH/R56-HL153311-01.
Deo R, Albert CM. Epidemiology and genetics of sudden cardiac death. Circulation. 2012;125:620–37.
Myerburg RJ, Goldberger JJ. Sudden cardiac arrest risk assessment: population science and the individual risk mandate. JAMA Cardiol. 2017;2:689–94.
Furukawa T, Rozanski JJ, Nogami A, Moroe K, Gosselin AJ, Lister JW. Time-dependent risk of and predictors for cardiac arrest recurrence in survivors of out-of-hospital cardiac arrest with chronic coronary artery disease. Circulation. 1989;80:599–608.
Myerburg RJ, Kessler KM, Estes D, et al. Long-term survival after prehospital cardiac arrest: analysis of outcome during an 8 year study. Circulation. 1984;70:538–46.
Golden J, Kitahata M, Lieu T, Wilson C, Steinmann W. Smoking as a risk factor for recurrence of sudden cardiac arrest. N Engl J Med. 1986;314:1641–2.
Yeo I, Cheung JW, Feldman DN, et al. Assessment of hospital readmission rates, risk factors, and causes after cardiac arrest: analysis of the US nationwide readmissions database. JAMA Netw Open. 2019;2:e1912208.
Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society. Heart Rhythm. 2018;15:e190–252.
Presciutti A, Shaffer J, Sumner JA, et al. Hyperarousal symptoms in survivors of cardiac arrest are associated with 13 month risk of major adverse cardiovascular events and all-cause mortality. Ann Behav Med. 2020;54:413–22.
Weston CS. Posttraumatic stress disorder: a theoretical model of the hyperarousal subtype. Front Psych. 2014;5:37.
Edmondson D, Richardson S, Falzon L, Davidson KW, Mills MA, Neria Y. Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review. PLoS ONE. 2012;7: e38915.
Roest AM, Martens EJ, Denollet J, de Jonge P. Prognostic association of anxiety post myocardial infarction with mortality and new cardiac events: a meta-analysis. Psychosom Med. 2010;72:563–9.
Berkman LF, Blumenthal J, Burg M, et al. Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA. 2003;289:3106–16.
Lichtman JH, Froelicher ES, Blumenthal JA, et al. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association. Circulation. 2014;129:1350–69.
Darden D, Richardson C, Jackson EA. Physical activity and exercise for secondary prevention among patients with cardiovascular disease. Curr Cardiovasc Risk Rep 2013;7.
Li J, Siegrist J. Physical activity and risk of cardiovascular disease–a meta-analysis of prospective cohort studies. Int J Environ Res Public Health. 2012;9:391–407.
Anderson L, Taylor RS. Cardiac rehabilitation for people with heart disease: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 2014:CD011273.
Lavie CJ, Thomas RJ, Squires RW, Allison TG, Milani RV. Exercise training and cardiac rehabilitation in primary and secondary prevention of coronary heart disease. Mayo Clin Proc. 2009;84:373–83.
Monane R, Sanchez GJ, Kronish IM, Edmondson D, Diaz KM. Post-traumatic stress disorder symptoms and aversive cognitions regarding physical activity in patients evaluated for acute coronary syndrome. Eur J Prev Cardiol. 2018;25:402–3.
Farris SG, Bond DS, Wu W-C, Stabile LM, Abrantes AM. Anxiety sensitivity and fear of exercise in patients attending cardiac rehabilitation. Ment Health Phys Act. 2018;15:22–6.
Farris SG, Abrantes AM, Bond DS, Stabile LM, Wu WC. Anxiety and fear of exercise in cardiopulmonary rehabilitation: PATIENT AND PRACTITIONER PERSPECTIVES. J Cardiopulm Rehabil Prev. 2019;39:E9–13.
Farris SG, Kibbey MM. Be brave, BE-FIT! A pilot investigation of an ACT-informed exposure intervention to reduce exercise fear-avoidance in older adults. Cogn Behav Ther. 2022;51:273–94.
Romero EK, Abdalla M, Thanataveerat A, et al. Short sleep duration after hospital evaluation for acute coronary syndrome is associated with increased risk of 6 month readmission. Psychosom Med. 2020;82:57–63.
Khan H, Kella D, Kunutsor SK, Savonen K, Laukkanen JA. Sleep duration and risk of fatal coronary heart disease, sudden cardiac death, cancer death, and all-cause mortality. Am J Med. 2018;131(1499–505): e2.
Liu TZ, Xu C, Rota M, et al. Sleep duration and risk of all-cause mortality: a flexible, non-linear, meta-regression of 40 prospective cohort studies. Sleep Med Rev. 2017;32:28–36.
Leng Y, Cappuccio FP, Wainwright NWJ, et al. Sleep duration and risk of fatal and nonfatal stroke: a prospective study and meta-analysis. Neurology. 2015;84:1072–9.
Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep. 2010;33:585–92.
Cronberg T, Lilja G, Rundgren M, Friberg H, Widner H. Long-term neurological outcome after cardiac arrest and therapeutic hypothermia. Resuscitation. 2009;80:1119–23.
Kronish IM, Cornelius T, Schwartz JE, et al. Posttraumatic stress disorder and electronically measured medication adherence after suspected acute coronary syndromes. Circulation. 2020;142:817–9.
Haywood KL, Whitehead L, Perkins GD. An international, consensus-derived Core Outcome Set for Cardiac Arrest effectiveness trials: the COSCA initiative. Curr Opin Crit Care. 2019;25:226–33.
Smith K, Andrew E, Lijovic M, Nehme Z, Bernard S. Quality of life and functional outcomes 12 months after out-of-hospital cardiac arrest. Circulation. 2015;131:174–81.
Epstein AE, DiMarco JP, Ellenbogen KA, et al. ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008;51:e1-62.
Wachelder EM, Moulaert VRMP, van Heugten C, Verbunt JA, Bekkers SCAM, Wade DT. Life after survival: long-term daily functioning and quality of life after an out-of-hospital cardiac arrest. Resuscitation. 2009;80:517–22.
Lim C, Verfaellie M, Schnyer D, Lafleche G, Alexander MP. Recovery, long-term cognitive outcome and quality of life following out-of-hospital cardiac arrest. J Rehabil Med. 2014;46:691–7.
Positive and negative psychological predictors of long-term recovery after cardiac arrest. Grantome, 2021. 2022, at https://grantome.com/grant/NIH/R01-HL151850-01A1.
Ladwig KH, Schoefinius A, Dammann G, Danner R, Gurtler R, Herrmann R. Long-acting psychotraumatic properties of a cardiac arrest experience. Am J Psychiatry. 1999;156:912–9.
Sawyer KN. Reintegration & recovery after surviving cardiac arrest: learning from the VACAR registry. Resuscitation. 2020;146:255–7.
Armand S, Wagner MK, Ozenne B, et al. Acute traumatic stress screening can identify patients and their partners at risk for posttraumatic stress disorder symptoms after a cardiac arrest: a multicenter prospective cohort study. J Cardiovasc Nurs 2021.
Presciutti A, Newman MM, Grigsby J, Vranceanu AM, Shaffer JA, Perman SM. Associations between posttraumatic stress symptoms and quality of life in cardiac arrest survivors and informal caregivers: a pilot survey study. Resusc Plus. 2021;5:100085.
Presciutti A, Newman MM, Sawyer KN, Agarwal S, Perman SM. Gaps in the provision of cognitive and psychological resources in cardiac arrest survivors with good neurologic recovery. Ther Hypothermia Temp Manag 2021.
Birk J, Sumner J, Heyman-Kantor R, et al. Efficacy of early interventions to prevent posttraumatic stress disorder in survivors of life-threatening medical events: a systematic review. J Affect Disord 2019.
Wade DM, Mouncey PR, Richards-Belle A, et al. Effect of a nurse-led preventive psychological intervention on symptoms of posttraumatic stress disorder among critically ill patients: a randomized clinical trial. JAMA. 2019;321:665–75.
Edmondson D, von Känel R. Post-traumatic stress disorder and cardiovascular disease. Lancet Psychiatry. 2017;4:320–9.
•• Edmondson D, Birk JL, Ho VT, Meli L, Abdalla M, Kronish IM. A challenge for psychocardiology: addressing the causes and consequences of patients’ perceptions of enduring somatic threat. Am Psychol. 2018;73:1160–71. Findings from this study suggest PTSD symptoms are common after survival from a life-threatening cardiovascular diseases, and there are certain behavioural and physiological mechanisms underlying the increased risk for subsequent cardiovascular events and mortality.
Otto MW, Smits JAJ. Anxiety sensitivity, health behaviors, and the prevention and treatment of medical illness. Clin Psychol (New York) 2018;25.
Smits JAJ, Berry AC, Tart CD, Powers MB. The efficacy of cognitive-behavioral interventions for reducing anxiety sensitivity: a meta-analytic review. Behav Res Ther. 2008;46:1047–54.
Kubzansky LD, Huffman JC, Boehm JK, et al. Positive psychological well-being and cardiovascular disease: JACC health promotion series. J Am Coll Cardiol. 2018;72:1382–96.
Forslund AS, Jansson JH, Lundblad D, Söderberg S. A second chance at life: people’s lived experiences of surviving out-of-hospital cardiac arrest. Scand J Caring Sci. 2017;31:878–86.
Scheier MF, Matthews KA, Owens JF, et al. Optimism and rehospitalization after coronary artery bypass graft surgery. Arch Intern Med. 1999;159:829–35.
Hoogwegt MT, Versteeg H, Hansen TB, Thygesen LC, Pedersen SS, Zwisler A-D. Exercise mediates the association between positive affect and 5-year mortality in patients with ischemic heart disease. Circ Cardiovasc Qual Outcomes 2013;6:559–66.
Kim ES, Sun JK, Park N, Kubzansky LD, Peterson C. Purpose in life and reduced risk of myocardial infarction among older US adults with coronary heart disease: a two-year follow-up. J Behav Med. 2013;36:124–33.
Bolier L, Haverman M, Westerhof GJ, Riper H, Smit F, Bohlmeijer E. Positive psychology interventions: a meta-analysis of randomized controlled studies. BMC Public Health. 2013;13:119.
Malouff JM, Schutte NS. Can psychological interventions increase optimism? A meta-analysis. J Posit Psychol. 2017;12:595–604.
Meevissen YM, Peters ML, Alberts HJ. Become more optimistic by imagining a best possible self: effects of a two week intervention. J Behav Ther Exp Psychiatry. 2011;42:371–8.
Leon AS, Franklin BA, Costa F, et al. Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (subcommittee on exercise, cardiac rehabilitation, and prevention) and the Council on Nutrition, Physical Activity, and Metabolism (subcommittee on physical activity), in collaboration with the American association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2005;111:369–76.
Austin J, Williams R, Ross L, Moseley L, Hutchison S. Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure. Eur J Heart Fail. 2005;7:411–7.
Pogosova N, Saner H, Pedersen SS, et al. Psychosocial aspects in cardiac rehabilitation: From theory to practice. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation of the European Society of Cardiology. Eur J Prev Cardiol 2015;22:1290–306.
Joshi VL, Christensen J, Lejsgaard E, Taylor RS, Zwisler AD, Tang LH. Effectiveness of rehabilitation interventions on the secondary consequences of surviving a cardiac arrest: a systematic review and meta-analysis. BMJ Open. 2021;11: e047251.
Dougherty CM, Thompson EA, Lewis FM. Long-term outcomes of a telephone intervention after an ICD. Pacing Clin Electrophysiol. 2005;28:1157–67.
Moulaert VR, van Heugten CM, Winkens B, et al. Early neurologically-focused follow-up after cardiac arrest improves quality of life at one year: a randomised controlled trial. Int J Cardiol. 2015;193:8–16.
Moulaert VR, van Haastregt JC, Wade DT, van Heugten CM, Verbunt JA. ‘Stand still …, and move on’, an early neurologically-focused follow-up for cardiac arrest survivors and their caregivers: a process evaluation. BMC Health Serv Res. 2014;14:34.
Kronish I, Edmondson D. Columbia Roybal Center for fearless behavior change. Paul and Gloria Milstein Division of Cardiology: Columbia University Department of Medicine Seymore; 2019.
Powers MB, Halpern JM, Ferenschak MP, Gillihan SJ, Foa EB. A meta-analytic review of prolonged exposure for posttraumatic stress disorder. Clin Psychol Rev. 2010;30:635–41.
Birk JL, Lopez-Veneros D, Cumella R, Agarwal S, Kronish IM. Surmounting the challenges of adapting a behavioral intervention for remote delivery during the COVID-19 pandemic: a case study of heart rate variability biofeedback training in cardiac arrest survivors. Psychosom Med. 2021;83(7):A40.
Goessl VC, Curtiss JE, Hofmann SG. The effect of heart rate variability biofeedback training on stress and anxiety: a meta-analysis. Psychol Med. 2017;47:2578–86.
Pizzoli SFM, Marzorati C, Gatti D, Monzani D, Mazzocco K, Pravettoni G. A meta-analysis on heart rate variability biofeedback and depressive symptoms. Sci Rep. 2021;11:6650.
Rae Olmsted KL, Bartoszek M, Mulvaney S, et al. Effect of Stellate Ganglion Block Treatment on Posttraumatic Stress Disorder Symptoms: A Randomized Clinical Trial. JAMA Psychiatry. 2020 Feb 1;77(2):130–138.
Auld JP, Thompson EA, Dougherty CM. Profiles of partner health linked to a partner-focused intervention following patient initial implantable cardioverter defibrillator (ICD). J Behav Med. 2021;44:630–40.
Bannon S, Lester EG, Gates MV, et al. Recovering together: building resiliency in dyads of stroke patients and their caregivers at risk for chronic emotional distress; a feasibility study. Pilot Feasibility Stud. 2020;6:75.
Recovering together: Building resiliency in dyads of patients admitted to the neuroscience intensive care unit (NICU) and their caregivers. 2018. at https://grantome.com/grant/NIH/R21-NR017979-01A1.
McIlroy PA, King RS, Garrouste-Orgeas M, Tabah A, Ramanan M. The effect of ICU diaries on psychological outcomes and quality of life of survivors of critical illness and their relatives: a systematic review and meta-analysis. Crit Care Med. 2019;47:273–9.
Funding
Sachin Agarwal was a Principal-investigator on a related NIH grant (R01-HL153311) that provided salary support for his effort. Jeffery L. Birk reports grants from the National Institutes of Health (R01-HL151850). Talea Cornelius receives support from the National Institutes of Health National Center for Advancing Translational Sciences (KL2TR001874). Bernard Chang receives support from the NIH (HL 141811 and HL 146911). Donald E. Edmondson was a co-investigator on related NIH grants that provided salary support for his effort. Ian Kronish received support from the National Heart, Lung, and Blood Institute (R01132347) and the National Institute on Aging (P30 AG064198).
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Talea Cornelius serves as a statistical consultant occasionally at the University of Conneticut. Bernard Chang reports consulting fees from Mighty Health, payment for expert testimony on a case, and Board of Director NY American College of Emergency Physicians. Ian Kronish receives an honorarium annually for service as a Section Editor for the journal Current Cardiology Reports. The other authors declare that they have no conflict of interest.
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This article is part of the Topical Collection on Psychological Aspects of Cardiovascular Diseases
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Agarwal, S., Birk, J.L., Abukhadra, S. et al. Psychological Distress After Sudden Cardiac Arrest and Its Impact on Recovery. Curr Cardiol Rep 24, 1351–1360 (2022). https://doi.org/10.1007/s11886-022-01747-9
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DOI: https://doi.org/10.1007/s11886-022-01747-9