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Role of Type 2 Innate Lymphoid Cells in Allergic Diseases

  • Immune Deficiency and Dysregulation (DP Huston and C Kuo, Section Editors)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The adaptive immune response orchestrated by type 2 T helper (Th2) lymphocytes, strictly cooperates with the innate response of group 2 innate lymphoid cells (ILC2), in the protection from helminths infection, as well as in the pathogenesis of allergic disease. The aim of this review is to explore the pathogenic role of ILC2 in different type 2-mediated disorders.

Recent Findings

Recent studies have shown that epithelial cell-derived cytokines and their responding cells, ILC2, play a pathogenic role in bronchial asthma, chronic rhinosinusitis, and atopic dermatitis.

Summary

The growing evidences of the contribution of ILC2 in the induction and maintenance of allergic inflammation in such disease suggest the possibility to target them in therapy. Biological therapies blocking ILC2 activation or neutralizing their effector cytokines are currently under evaluation to be used in patients with type 2-dominated diseases.

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Acknowledgments

We thank Dr. Beatrice Rossettini and Dr. Gianni Montaini for their support in the preparation of the figure

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Correspondence to Francesco Annunziato.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Immune Deficiency and Dysregulation

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Cosmi, L., Liotta, F., Maggi, L. et al. Role of Type 2 Innate Lymphoid Cells in Allergic Diseases. Curr Allergy Asthma Rep 17, 66 (2017). https://doi.org/10.1007/s11882-017-0735-9

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