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What Does Tympanostomy Tube Placement in Children Teach Us About the Association Between Atopic Conditions and Otitis Media?

  • OTITIS (DP SKONER, SECTION EDITOR)
  • Published:
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Abstract

Otitis media is the most common infection second only to viral upper respiratory infection in the outpatient setting. Tympanostomy tube insertion (TTI) is the most common ambulatory surgical procedure in the USA. While many risk factors for otitis media have been identified, atopic conditions have been underrecognized as risk factors for recurrent and persistent otitis media. Given that asthma and other atopic conditions are the most common chronic conditions during childhood, it is worth examining the association between atopic conditions and risk of otitis media, which can provide insight into how atopic conditions influence the risk of microbial infections. This paper focuses its discussion on otitis media; however, it is important that the association between atopic conditions and risk of otitis media be interpreted in the context of the association of atopic conditions with increased risks of various microbial infections.

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Abbreviations

95 % CI:

95 % confidence interval

CMI:

Cell-mediated immunity

CVID:

Common variable immunodeficiency

HIV:

Human immunodeficiency virus

HR:

Hazard ratios

ICS:

Inhaled corticosteroid

IPD:

Invasive pneumococcal disease

OR:

Odds ratios

PAR%:

Population attributable risk percent

PBMC:

Peripheral blood mononuclear cells

PCV7:

7-Valent pneumococcal conjugate vaccine

PPV23:

23-Valent pneumococcal polysaccharide vaccine

RR:

Risk ratios

Th1:

T helper 1 cells

Th2:

T helper 2 cells

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Conflict of Interest

Young J. Juhn and Chung-Il Wi declare that they have no conflict of interest.

Funding

The work was supported by grants from the National Institute of Allergy and Infectious Diseases (R21 AI101277), Agency for Healthcare Research and Quality of the United States (R01HS018431-01A1), NIH Relief Fund, and Scholarly Clinician Award from Mayo Foundation.

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  1. Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

    Young J. Juhn & Chung-Il Wi

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  1. Young J. Juhn
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Correspondence to Young J. Juhn.

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This article is part of the Topical Collection on Otitis

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Juhn, Y.J., Wi, CI. What Does Tympanostomy Tube Placement in Children Teach Us About the Association Between Atopic Conditions and Otitis Media?. Curr Allergy Asthma Rep 14, 447 (2014). https://doi.org/10.1007/s11882-014-0447-3

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