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Enhanced Photodynamic Therapy by Improved Light Energy Capture Efficiency of Porphyrin Photosensitizers

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Opinion Statement

Photodynamic therapy (PDT) has garnered increasing attention in cancer treatment because of its advantages such as minimal invasiveness and selective destruction. With the development of PDT, impressive progress has been made in the preparation of photosensitizers, particularly porphyrin photosensitizers. However, the limited tissue penetration of the activating light wavelengths and relatively low light energy capture efficiency of porphyrin photosensitizers are two major disadvantages in conventional photosensitizers. Therefore, tissue penetration needs to be enhanced and the light energy capture efficiency of porphyrin photosensitizers improved through structural modifications. The indirect excitation of porphyrin photosensitizers using fluorescent donors (fluorescence resonance energy transfer) has been successfully used to address these issues. In this review, the enhancement of the light energy capture efficiency of porphyrins is discussed.

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Funding

This work was supported by Hunan Province’s Students Innovation and Entrepreneurship Training Program (Xiangjiaotong [2022] 174–3149) and Scientific Research Program of Hunan Health Commission in 2019 (B2019113).

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Authors and Affiliations

  1. Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, 28 Changsheng Road, Hengyang City, Hunan Province, 421001, China

    Zejie Tian MMed, Hui Li MMed, Zhenhua Liu MMed, Lingyan Yang MMed & Yunmei Liu PhD

  2. Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Changsheng Road, Hengyang City, Hunan Province, 421001, China

    Zejie Tian MMed, Hui Li MMed, Zhenhua Liu MMed, Lingyan Yang MMed & Yunmei Liu PhD

  3. Institute of Chemistry & Chemical Engineering, University of South China, Hengyang City, Hunan Province, 421001, China

    Chaoyang Zhang B.Sc & Jun He M.Sc

  4. The Second Affiliated Hospital of University of South China, Hengyang City, Hunan Province, 421001, China

    Wenbin Ai MMed

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  1. Zejie Tian MMed
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  8. Yunmei Liu PhD
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All authors contributed to the study conception and design. The first draft of the manuscript was written by Zejie Tian, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Yunmei Liu PhD.

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Tian, Z., Li, H., Liu, Z. et al. Enhanced Photodynamic Therapy by Improved Light Energy Capture Efficiency of Porphyrin Photosensitizers. Curr. Treat. Options in Oncol. 24, 1274–1292 (2023). https://doi.org/10.1007/s11864-023-01120-0

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