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Circulating Biomarkers for Cardiotoxicity Risk Prediction

  • Cardio-oncology (MG Fradley, Section Editor)
  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion statement

Improvements in cancer survival have led to the emergence of cardiovascular disease as an important determinant of adverse outcome in survivors. Cancer therapeutics–related cardiac dysfunction is the most well-known form of cardiotoxicity. However, newer cancer therapies bring a broader range of cardiotoxicities. The optimal method to identify patients at risk of these complications is unclear, but circulating biomarkers comprise one possible approach. Troponins and natriuretic peptides have garnered the broadest evidence base for cardiotoxicity risk prediction, but other markers are being investigated. In this review, we explore evidence for circulating biomarkers in cardiotoxicity prediction associated with cancer therapies.

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Abbreviations

BNP:

Brain-type natriuretic peptide

cTn:

Cardiac troponins

cTnI:

Cardiac troponin I

cTnT:

Cardiac troponin T

CTRCD:

Cancer therapeutics–related cardiac dysfunction

HER2:

Human epidermal growth factor receptor 2

LVEF:

Left ventricular ejection fraction

NT-proBNP:

Amino-terminal pro-brain-type natriuretic peptide

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  1. Division of Cardiology, Northwestern University Feinberg School of Medicine, 676 N St Clair, Suite 600, Chicago, IL, 60611, USA

    Fei Fei Gong MBBS, PhD, Gregory J. Cascino MD & Nausheen Akhter MD

  2. Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, CP1-3, Abbott Park, North Chicago, IL, 60064-6094, USA

    Gillian Murtagh MD

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  1. Fei Fei Gong MBBS, PhD
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Fei Fei Gong declares that she has no conflict of interest. Gregory J. Cascino declares that he has no conflict of interest. Gillian Murtagh is a shareholder and full-time employee of Abbott Laboratories. Nausheen Akhter declares that she has no conflict of interest.

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Gong, F.F., Cascino, G.J., Murtagh, G. et al. Circulating Biomarkers for Cardiotoxicity Risk Prediction. Curr. Treat. Options in Oncol. 22, 46 (2021). https://doi.org/10.1007/s11864-021-00845-0

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