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Neither the presence nor the severity of hyponatremia affected the outcome of the patients with small cell lung cancer

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Abstract

Background

Hyponatremia is the most common electrolyte disorder in lung cancer, and it particularly occurs in small cell lung cancer (SCLC) patients. The prognostic significance of hyponatremia has been reported in several studies with controversial results.

Aims

We aimed in this study to investigate hyponatremia and evaluate its prognostic value in SCLC patients.

Methods

The data of 373 SCLC patients were analyzed retrospectively. Serum sodium concentrations were measured from blood samples taken from all patients before treatment. Hyponatremia was defined as a serum sodium concentration below 135 mmol/L and then assigned into two groups: mild (130 to 134 mmol/L) and severe (below ≤ 129 mmol/L) hyponatremia.

Results

Hyponatremia was detected in 85 (22.8%) patients (mild hyponatremia in 51 (13.7%) and severe hyponatremia in 34 (9.1%) patients). Furthermore, 26% (63 of 242) of ED-SCLC patients and 16.8% (22 of 131) of LD-SCLC patients had hyponatremia. While no clinical parameter was statistically associated with serum sodium concentrations in LD-SCLC patients, hyponatremic ED-SCLC patients were more frequently associated with weight loss (p = 0.04) and liver metastasis (p = 0.04). In LD-SCLC, the overall survival (OS) rates of patients with hyponatremia were similar to those with normonatremia (p = 0.6). Likewise, hyponatremic and normonatremic ED-SCLC patients had similar life expectancies (p = 0.1). Moreover, the severity of hyponatremia did not affect OS in either LD-SCLC (p = 0.3) or ED-SCLC (p = 0.1).

Conclusion

Serum sodium concentration did not have an impact on survival in SCLC patients; thus, we concluded that neither the presence nor the severity of hyponatremia affected the outcome of these patients.

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References

  1. Fiordoliva I, Meletani T, Baleani MG et al (2017) Managing hyponatremia in lung cancer: latest evidence and clinical implications. Ther Adv Med Oncol 9:711–719

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Fuca G, Mariani L, Vullo SL et al (2019) Weighing the prognostic role of hyponatremia in hospitalized patients with metastatic solid tumors: the HYPNOSIS study. Sci Rep 9:12993

    Article  PubMed  PubMed Central  Google Scholar 

  3. Wang W, Song Z, Zhang Y (2016) Hyponatremia in small cell lung cancer is associated with a poorer prognosis. Transl Cancer Res 5:36–43

    CAS  Google Scholar 

  4. Hansen O, Sørensen P, Hansen KH (2010) The occurrence of hyponatremia in SCLC and the influence on prognosis: a retrospective study of 453 patients treated in a single institution in a 10-year period. Lung Cancer 68:111–114

    Article  PubMed  Google Scholar 

  5. Hermes A, Waschki B, Reck M (2012) Hyponatremia as prognostic factor in small cell lung cancer–a retrospective single institution analysis. Respir Med 106:900–904

    Article  PubMed  Google Scholar 

  6. Tiseo M, Buti S, Boni L et al (2014) Prognostic role of hyponatremia in 564 small cell lung cancer patients treated with topotecan. Lung Cancer 86:91–95

    Article  PubMed  Google Scholar 

  7. Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A (2021) Hyponatremia in lung cancer: incidence and prognostic value in a Danish population-based cohort study. Lung Cancer 153:42–48

    Article  CAS  PubMed  Google Scholar 

  8. Yang Y, Sun N, Sun P, Zhang L (2017) Clinical characteristics and prognosis of elderly small cell lung cancer patients complicated with hyponatremia: a retrospective analysis. Anticancer Res 37:4681–4686

    PubMed  Google Scholar 

  9. Allan SG, Stewart ME, Love S et al (1990) Prognosis at presentation of small cell carcinoma of the lung. Eur J Cancer 26:703–705

    Article  CAS  PubMed  Google Scholar 

  10. Umemura S, Segawa Y, Ueoka H et al (2007) Serum level of arginine-vasopressin influences the prognosis of extensive disease small-cell lung cancer. J Cancer Res Clin Oncol 133:519–524

    Article  CAS  PubMed  Google Scholar 

  11. Castillo JJ, Vincent M, Justice E (2012) Diagnosis and management of hyponatremia in cancer patients. Oncologist 17:756–765

    Article  PubMed  PubMed Central  Google Scholar 

  12. Bartalis E, Gergics M, Tinusz B et al (2021) Prevalence and prognostic significance of hyponatremia in patients with lung cancer: systemic review and meta-analysis. Front Med 8:671951

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey

    Faruk Tas

  2. Department of Medical Oncology Outpatient Clinic, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey

    Akin Ozturk

  3. Department of Medical Oncology, Koc University, Istanbul, Turkey

    Kayhan Erturk

Authors
  1. Faruk Tas
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  2. Akin Ozturk
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  3. Kayhan Erturk
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Correspondence to Faruk Tas.

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Tas, F., Ozturk, A. & Erturk, K. Neither the presence nor the severity of hyponatremia affected the outcome of the patients with small cell lung cancer. Ir J Med Sci 192, 1613–1619 (2023). https://doi.org/10.1007/s11845-022-03199-0

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  • DOI: https://doi.org/10.1007/s11845-022-03199-0

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