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Histopathological gallbladder morphometric measurements in geriatric patients with symptomatic chronic cholecystitis

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Abstract

Introduction

Cholecystectomy for symptomatic cholecystitis is one of the common surgical procedures in the geriatric patients. Increased gallbladder wall thickness is expected due to acute cholecystitis and in some other clinical conditions. Routine histopathological evaluation of cholecystectomy materials are required to confirm the diagnosis and document other pathologies. The aim of this study was to evaluate age-related histopathological gallbladder morphometric measurements.

Methods

A retrospective chart review of 371 cholecystectomy materials was performed. Two groups were designed according to age (<65 and ≥65 years old, respectively). Age and gender analyses for histopathological gallbladder length, diameter and wall thickness were performed. In addition, pathologically confirmed acute inflammation rates were evaluated in this case–control study.

Results

Gallbladder morphometric measurements and pathologically confirmed acute inflammation rates were similar in males and females. Histopathological gallbladder diameter was higher with acute inflammatory changes, but no differences were observed in gallbladder length and wall thickness. Gallbladder wall thickness and pathologically confirmed acute inflammation rates were not comparable between the control and geriatric patients (2.8 ± 1.3 vs 2.6 ± 1.2 mm, and 30/281 (10.7 %) vs 10/74 (13.5 %), respectively, p > 0.05). However, higher gallbladder length and diameter were observed in geriatric group.

Conclusion

Age is an independent factor on histopathological gallbladder length and diameter, but not for gallbladder wall thickness. In addition, pathologically confirmed acute inflammation rate is not higher in geriatric patients. Clinical significance of these findings merits further investigation.

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Acknowledgments

No funding was received for this study and publication. All named authors meet the ICMJE criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval to the version to be published.

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Authors and Affiliations

  1. Department of General Surgery, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey

    F. Yaylak, Z. Bayhan, S. Zeren & M. C. Algın

  2. Department of Pathology, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey

    A. Deger & C. Kocak

  3. Department of Biochemistry, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey

    F. E. Kocak

  4. Department of General Surgery, Evliya Celebi Education and Training Hospital, 43020, Kutahya, Turkey

    M. F. Ekici

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  1. F. Yaylak
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  2. A. Deger
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  3. Z. Bayhan
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  4. C. Kocak
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  5. S. Zeren
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  6. F. E. Kocak
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  7. M. F. Ekici
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  8. M. C. Algın
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Correspondence to Z. Bayhan.

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Yaylak, F., Deger, A., Bayhan, Z. et al. Histopathological gallbladder morphometric measurements in geriatric patients with symptomatic chronic cholecystitis. Ir J Med Sci 185, 871–876 (2016). https://doi.org/10.1007/s11845-015-1385-3

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  • DOI: https://doi.org/10.1007/s11845-015-1385-3

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