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Vapor-phase synthesis of a robust polysulfide film for transparent, biocompatible, and long-term stable anti-biofilm coating

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Abstract

Biofilm formation caused by the fouling of microorganisms is one of the major problems in biomedical devices, food industry, and marine transportation. Since the removal of adherent biofilm is not a trivial task, it is of paramount importance to contain the formation of the anti-biofilm film. Herein, a polysulfide-based anti-biofilm coating (PAC) equipped with full transparency, non-toxicity, and environmental stability was developed via a simple vapor-phase synthesis. The polymer coating consists of polysulfide chain grafted onto poly (1,3,5,7-tetramethyl-1,3,5,7-tetravinyl cyclotetrasiloxane) (pV4D4) layer via thiol-ene click reaction, which was accomplished via a sequential deposition of each polymer followed by UV irradiation. The pV4D4 served as an adhesion promoter layer that substantially enhanced the interfacial adhesion between polysulfide layer and various substrate materials. The polysulfide layer exhibits a long-lasting anti-biofilm performance against pathogenic bacteria, such as Escherichia coli: O157 and Staphylococcus aureus. The excellent anti-biofilm property is attributed to slippery surface derived from the non-adherent, dynamic characteristics of the polysulfide (-S-S-) chain. The anti-biofilm coating indeed shows outstanding durability and robustness when exposed to extreme pH, organic solvents, and mechanical stresses. The fully transparent, robust coating developed in this study is a promising candidate material for a broad range of anti-biofilm applications.

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Acknowledgements

Hogi Kim and Seonghyeon Park contributed equally to this work. This research was supported in part by National R&D Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT (Grant No. NRF-2021M3H4A 4079293), a grant from the Technology Innovation Program (No. 20008777) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea), and Nanomedical Devices Development Project of NNFC in 2022 (No. 1711160154). This study was also supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2020R1I1A1A01066621).

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, 34141, Korea

    Hogi Kim, Seonghyeon Park, Younseong Song, Wontae Jang, Keonwoo Choi, Eunjung Lee & Sung Gap Im

  2. Nano-bio Application Team, National Nanofab Center (NNFC), Daejeon, 34141, Korea

    Kyoung G. Lee

  3. KAIST Institute for the NanoCentury (KINC), Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea

    Sung Gap Im

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  1. Hogi Kim
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  2. Seonghyeon Park
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  3. Younseong Song
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  4. Wontae Jang
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  5. Keonwoo Choi
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  6. Kyoung G. Lee
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  7. Eunjung Lee
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  8. Sung Gap Im
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Correspondence to Eunjung Lee or Sung Gap Im.

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Co-first authors.

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The authors declare no competing financial interest.

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Additional information as noted in the text. This information is available via the Internet at http://www.springer.com/chemistry/journal/11814.

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11814_2022_1275_MOESM1_ESM.pdf

Vapor-phase synthesis of a robust polysulfide film for transparent, biocompatible, and long-term stable anti-biofilm coating

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Kim, H., Park, S., Song, Y. et al. Vapor-phase synthesis of a robust polysulfide film for transparent, biocompatible, and long-term stable anti-biofilm coating. Korean J. Chem. Eng. 40, 412–418 (2023). https://doi.org/10.1007/s11814-022-1275-0

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  • DOI: https://doi.org/10.1007/s11814-022-1275-0

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