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Recent advances in protein-based nanoparticles

  • Invited Review Paper
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Korean Journal of Chemical Engineering Aims and scope Submit manuscript

Abstract

Certain naturally occurring proteins consist of a number of subunit building blocks that are capable of self-assembling to form nanoscale particles with highly organized, symmetrical, and homogeneous structures. These protein-based nanoparticles have high surface/volume ratios and other favorable properties, including mono-dispersibility, high stability, low toxicity, biocompatibility, biodegradability, and capacity for easy genetic and chemical modification. Thus, these particles have attracted considerable research attention and have been manipulated for various applications in different fields. This review describes the engineering of existing protein nanoparticles, with a particular focus on scientific advances in diverse applications, including bioassays, molecular imaging diagnostics, drug delivery, biocatalysis, and materials science. In addition, barriers for the widespread industrial use of such nanoparticles and outlook for the design and creation of novel self-assembled protein-based nanoparticles are considered.

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  1. Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, Daegu, 41566, Korea

    Eun Jung Lee

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Eun Jung Lee is an Assistant Professor in the Department of Chemical Engineering at Kyungpook National University in Korea. She received her B.S. (2007) and Ph.D. (2014) degree in Chemical and Biological Engineering at Korea University. She was a research professor in the Institute of Clean Chemical Engineering Systems at Korea University and a postdoctoral fellow in the Biomedical Research Institute at the Korea Institute of Science and Technology (KIST) before joining Kyungpook National University in 2017. Her research interests include nano-biomaterials, protein-based nanoparticle and hydrogel, nanomedicine, biosensor, drug delivery and cancer immunotherapy.

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Lee, E.J. Recent advances in protein-based nanoparticles. Korean J. Chem. Eng. 35, 1765–1778 (2018). https://doi.org/10.1007/s11814-018-0102-0

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