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A label-free single photonic quantum well biosensor based on porous silicon for DNA detection

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Abstract

The single photonic quantum well (PQW) structures are successfully fabricated on p-type silicon wafer by electrochemical etching process, and are used for DNA detection firstly. The red shift of resonance peak is caused by the changing refractive index of PSi layer, which results from coupling of organic molecules into pores. When the porous silicon (PSi) based single PQW biosensors are immersed in complementary deoxyribonucleic acid (DNA) with different concentrations ranging from 0.625 μM to 10.000 μM, a good linear relationship is observed between the red shift of resonance peak and the complementary DNA concentration. Experimental results show that the detection sensitivity of PSi-based single PQW biosensors is 3.04 nm/μM with a detection limit of 32 nM for 16-base pair DNA oligonucleotides.

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Authors and Affiliations

  1. School of Physical Science and Technology, Xinjiang University, Urumqi, 830046, China

    Rong-xia Liu  (刘荣霞) & Hong-yan Zhang  (张红燕)

  2. Key Laboratory of Xinjiang Biological Resources and Gene Engineering, College of Life Sciences and Technology, Xinjiang University, Urumqi, 830046, China

    Liang-liang Chen  (陈亮亮)

  3. College of Information Science and Engineering, Xinjiang University, Urumqi, 830046, China

    Zhen-hong Jia  (贾振红)

Authors
  1. Rong-xia Liu  (刘荣霞)
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  2. Liang-liang Chen  (陈亮亮)
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  3. Hong-yan Zhang  (张红燕)
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  4. Zhen-hong Jia  (贾振红)
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Corresponding author

Correspondence to Zhen-hong Jia  (贾振红).

Additional information

This work has been supported by the National Natural Science Foundation of China (Nos.61265009 and 11264038), the Research Foundation for the Doctoral Program of Chinese universities (No.20116501110003), and the Xinjiang Science and Technology Project (No. 201291109).

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Liu, Rx., Chen, Ll., Zhang, Hy. et al. A label-free single photonic quantum well biosensor based on porous silicon for DNA detection. Optoelectron. Lett. 9, 225–228 (2013). https://doi.org/10.1007/s11801-013-3020-8

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  • DOI: https://doi.org/10.1007/s11801-013-3020-8

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