Abstract
We consider marginal generalized partially linear single-index models for longitudinal data. A profile generalized estimating equations (GEE)-based approach is proposed to estimate unknown regression parameters. Within a wide range of bandwidths for estimating the nonparametric function, our profile GEE estimator is consistent and asymptotically normal even if the covariance structure is misspecified. Moreover, if the covariance structure is correctly specified, the semiparametric efficiency can be achieved under heteroscedasticity and without distributional assumptions on the covariates. Simulation studies are conducted to evaluate the finite sample performance of the proposed procedure. The proposed methodology is further illustrated through a data analysis.
Similar content being viewed by others
References
Bai Y, Fung WK, Zhu Z (2009) Penalized quadratic inference functions for single-index models with longitudinal data. J Multivar Anal 100:152–161
Bickel PJ, Klaassen AJ, Ritov Y, Wellner JA (1993) Efficient and adaptive inference in semiparametric models. Johns Hopkins University Press, Baltimore
Cantoni E, Filed C, Flemming JM, Ronchetti E (2005) Longitudinal variable selection by cross-validation in the case of many covariates. Stat Med 26:919–930
Carroll R, Fan J, Gijbels I, Wand M (1997) Generalized partially linear single-index models. J Am Stat Assoc 92:477–489
Chen H (1988) Convergence rates for parametric components in a partial linear model. Ann Stat 16:136–146
Chen K, Jin Z (2006) Partial linear regression models for clustered data. J Am Stat Assoc 101:195–204
Cheng G, Zhou L, Huang J (2014) Efficient semiparametric estimation in generalized partially linear additive models for longitudinal/clustered data. Bernoulli 20:141–163
Cui X, Häddle W, Zhu L (2011) The EFM approach for single-index models. Ann Stat 39:1658–1688
Fan J, Gijbels I (1996) Local polynomial modelling and its applications. Chapman & Hall, London
Häddle W, Hall P, Ichimura H (1993) Optimal smoothing in single-index models. Ann Stat 21:157–178
Hu J, Wang P, Qu A (2014) Estimating and identifying unspecified correlation structure for longitudinal data. J Comput Graph Stat. doi:10.1080/10618600.2014.909733
Huang JZ, Zhang L, Zhou L (2007) Efficient estimation in marginal partially linear models for longitudinal/clustered data using splines. Scand J Stat 34:451–477
Kress R (1989) Linear integral equations, 2nd edn. Springer, New York
Lai P, Li G, Lian H (2013) Quadratic inference functions for partially linear single-index models with longitudinal data. J Multivar Anal 118:115–127
Lai P, Wang Q, Zhou X (2014) Variable selection and semiparametric efficient estimation for the heteroscedastic partially linear single-index model. Comput Stat Data Anal 70:241–256
Li Y (2011) Efficient semiparametric regression for longitudinal data with nonparametric covariance estimatioin. Biometrika 98:355–370
Li G, Zhu L, Xue L, Feng S (2010) Emiprical likelihood inference in partially linear single-index models for longitudinal data. J Multivar Anal 101:718–732
Li G, Lai P, Lian H (2015) Variable selection and estimation for partially linear single-index models with longitudinal data. Stat Comput 25:579–593
Liang KY, Zeger SL (1986) Longitudinal data analysis using generalised linear models. Biometrika 73:12–22
Liang H, Liu X, Li R, Tsai C (2010) Estimation and testing for partially linear single-index models. Ann Stat 38:3811–3836
Ma Y, Chiou J, Wang N (2006) Semiparametric estimator in partially linear models. Biometrika 93:75–84
McCullagh P, Nelder JA (1989) Generalized linear models, 2nd edn. Chapman & Hall, London
Pepe MS, Anderson GL (1994) A cautionary note on inference for marginal regression models with longitudinal data and general correlated response data. Commun Stat Simul Comput 23:939–951
Speckman P (1988) Kernel smoothing in partial linear models. J R Stat Soc Ser B 50:413–436
Wang N (2003) Marginal nonparametric kernel regression accounting for within-subject correlation. Biometrika 90:43–52
Wang N, Carroll R, Lin X (2005a) Efficient semiparametric marginal estimation for longitudinal/clustered data. J Am Stat Assoc 100:147–157
Wang Y, Lin X, Zhu M (2005b) Robust estimating functions and bias correction for longitudinal data analysis. Biometrics 61:684–691
Wang J, Xue L, Zhu L, Chong Y (2010) Estimation for a partial-linear single-index model. Ann Stat 38:246–274
Xu J, Wang Y (2014) Intra-cluster correlation structure in longitudinal data analysis: selectioin criteria and misspecification tests. Comput Stat Data Anal 80:70–77
Xu P, Zhu L (2012) Estimation for a marginal generalized single-index longitudinal model. J Multivar Anal 105:285–299
Xue L, Zhu L (2006) Empirical likelihood for single-index models. J Multivar Anal 97:1295–1312
Yi G, He W, Liang H (2009) Analysis of correlated binary data under partially linear single-index logistic models. J Multivar Anal 100:278–290
Yi G, He W, Liang H (2011) Semiparametric marginal and association regression methods for clustered binary data. Ann Inst Stat Math 63:511–533
Yu Y, Ruppert D (2002) Penalized spline estimation for partially linear single-index models. J Am Stat Assoc 97:1042–1054
Zhang J, Gai Y, Wu P (2013) Linear regression with measurement errors subject to single-indexed distortion. Comput Stat Data Anal 59:103–120
Zhang J, Wang X, Yu Y, Gai Y (2014) Estimation and variable selection in partial linear single index models with error-prone linear covariates. Statistics 48:1048–1070
Zhou J, Qu A (2012) Informative estimation and selection of correlation structure for longitudinal data. J Am Stat Assoc 107:725–736
Zhu L, Xue L (2006) Empirical likelihood confidence regions in a partially linear single-index model. J R Stat Soc Ser B 68:549–570
Acknowledgments
The authors thank the editor, the associate editor and two anonymous referees for their many helpful comments that have resulted in significant improvements in the article. Peirong Xu was supported by the Natural Science Foundation of Jiangsu Province, China (No. BK20140617) and the National Natural Science Foundation of China (NSFC) Grant No. 11501099. Jun Zhang was supported by the National Natural Science Foundation of China (NSFC) Grant No. 11401391 and the Project of Department of Education of Guangdong Province of China, Grant No. 2014KTSCX112. Xingfang Huang was supported by the National Natural Science Foundation of China (NSFC) Grant No. 11401094 and the Humanities and Social Science Foundation of Ministry of Education of China (13YJC910006).
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Xu, P., Zhang, J., Huang, X. et al. Efficient estimation for marginal generalized partially linear single-index models with longitudinal data. TEST 25, 413–431 (2016). https://doi.org/10.1007/s11749-015-0462-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11749-015-0462-2
Keywords
- Generalized partially single-index models
- Generalized estimating equations
- Longitudinal data
- Semiparametric efficiency