Skip to main content
Log in

A proposal of postoperative follow-up pathways for lung cancer

  • Original Article
  • Published:
General Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Objectives

Although follow-up surveillance after resection for lung cancer is commonly performed in clinical practice, there is no standard follow-up program. We attempted to establish follow-up examination schedules that we considered would be acceptable to the majority of doctors, and would like to propose them as standard postoperative follow-up pathways.

Methods

We carried out a retrospective analysis of patients’ data and reviewed the time of detection of recurrence and the site of recurrence after resection. Published papers were also reviewed. The postoperative follow-up pathways were established based on these data.

Proposed follow-up pathway

The follow-up period was set at as 5 years after resection, and physical examinations, chest radiography, chest CT and blood examination are recommended. Two follow-up pathways were proposed taking the risk of recurrence into consideration: the Risk of recurrence-based pathway and the Comprehensive pathway. In the Risk of recurrence-based pathway, the follow-up examination schedule is modified according to the risk of recurrence. In the Comprehensive pathway, a single universal examination schedule is recommended for all patients. The choice between these two pathways is left to the discretion of the attending doctor.

Conclusions

We proposed two follow-up pathways, based on retrospective analysis of patients’ data and a review of published papers, which we considered would be acceptable to the majority of doctors and would be suited to the current medical environment in Japan. A prospective study to evaluate the efficacy of the follow-up pathways is ongoing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Egermann U, Jaeggi K, Habicht JM, Perruchoud AP, Dalquen P, Soler M. Regular follow-up after curative resection of nonsmall cell lung cancer: a real benefit for patients? Eur Respir J. 2002;19:464–8.

    Article  CAS  PubMed  Google Scholar 

  2. Virgo KS, Naunheim KS, McKirgan LW, Kissling ME, Lin JC, Johnson FE. Cost of patient follow-up after potentially curative lung cancer treatment. J Thorac Cardiovasc Surg. 1996;112:356–63.

    Article  CAS  PubMed  Google Scholar 

  3. Walsh GL, O’Connor M, Willis KM, Milas M, Wong RS, Nesbitt JC, et al. Is follow-up of lung cancer patients after resection medically indicated and cost-effective? Ann Thorac Surg. 1995;60:1563–70 (discussion 1570–1562).

    Article  CAS  PubMed  Google Scholar 

  4. Younes RN, Gross JL, Deheinzelin D. Follow-up in lung cancer: how often and for what purpose? Chest. 1999;115:1494–9.

    Article  CAS  PubMed  Google Scholar 

  5. Chiu CH, Chern MS, Wu MH, Hsu WH, Wu YC, Huang MH, et al. Usefulness of low-dose spiral CT of the chest in regular follow-up of postoperative non-small cell lung cancer patients: preliminary report. J Thorac Cardiovasc Surg. 2003;125:1300–5.

    Article  PubMed  Google Scholar 

  6. Westeel V, Choma D, Clement F, Woronoff-Lemsi MC, Pugin JF, Dubiez A, et al. Relevance of an intensive postoperative follow-up after surgery for non-small cell lung cancer. Ann Thorac Surg. 2000;70:1185–90.

    Article  CAS  PubMed  Google Scholar 

  7. Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol. 2012;17:1–29.

    Article  PubMed  Google Scholar 

  8. Pretreatment evaluation of non-small-cell lung cancer. The American Thoracic Society and The European Respiratory Society. Am J Respir Crit Care Med. 1997;156:320–32.

  9. Pfister DG, Johnson DH, Azzoli CG, Sause W, Smith TJ, Baker S Jr, et al. American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol. 2004;22:330–53.

    Article  PubMed  Google Scholar 

  10. Felip E, Stahel RA, Pavlidis N. ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of non-small-cell lung cancer (NSCLC). Ann Oncol. 2005;16(Suppl 1):i28–9.

    Article  PubMed  Google Scholar 

  11. Rubins J, Unger M, Colice GL. Follow-up and surveillance of the lung cancer patient following curative intent therapy: ACCP evidence-based clinical practice guideline (2nd edition). Chest. 2007;132:355S–67S.

    Article  PubMed  Google Scholar 

  12. Follow-up of non-small lung cancer. American College of Radiology appropriateness criteria, 2005 2007; http://www.acr.org.

  13. Sawada S, Suehisa H, Yamashita M, Nakata M, Okumura N, Okabe K, et al. Current status of postoperative follow-up for lung cancer in Japan: questionnaire survey by the Setouchi Lung Cancer Study Group-A0901. Gen Thorac Cardiovasc Surg. 2012;60:104–11.

    Article  PubMed  Google Scholar 

  14. Okada M, Nishio W, Sakamoto T, Harada H, Uchino K, Tsubota N. Long-term survival and prognostic factors of five-year survivors with complete resection of non-small cell lung carcinoma. J Thorac Cardiovasc Surg. 2003;126:558–62.

    Article  PubMed  Google Scholar 

  15. Martini N, Rusch VW, Bains, Kris MG, Downey RJ, Flehinger BJ, et al. Factors influencing ten-year survival in resected stages I to IIIa non-small cell lung cancer. J Thorac Cardiovasc Surg. 1999;117:32–6 (discussion 37–38).

    Article  CAS  PubMed  Google Scholar 

  16. Nakao M, Yoshida J, Goto K, Ishii G, Kawase A, Aokage K, et al. Long-term outcomes of 50 cases of limited-resection trial for pulmonary ground-glass opacity nodules. J Thorac Oncol. 2012;7(1563–1566):15. doi:10.1097/JTO.1560b1013e3182641b3182645c.

    Google Scholar 

  17. Altorki N, Kent M, Pasmantier M. Detection of early-stage lung cancer: computed tomographic scan or chest radiograph? J Thorac Cardiovasc Surg. 2001;121:1053–7.

    Article  CAS  PubMed  Google Scholar 

  18. Lee JI, Lee YJ, Park KY, Park CH, Jeon YB, Choi CH, et al. Fate of newly detected lesions during postoperative surveillance for non-small cell lung cancer. Ann Thorac Surg. 2013;95:1867–71.

    Article  PubMed  Google Scholar 

  19. Diederich S, Semik M, Lentschig MG, Winter F, Scheld HH, Roos N, et al. Helical CT of pulmonary nodules in patients with extrathoracic malignancy: CT-surgical correlation. AJR Am J Roentgenol. 1999;172:353–60.

    Article  CAS  PubMed  Google Scholar 

  20. Okada M, Nishio W, Sakamoto T, Uchino K, Yuki T, Nakagawa A, et al. Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease. Ann Thorac Surg. 2004;78:216–21.

    Article  PubMed  Google Scholar 

  21. Choi SH, Kim YT, Kim SK, Kang KW, Goo JM, Kang CH, et al. Positron emission tomography-computed tomography for postoperative surveillance in non-small cell lung cancer. Ann Thorac Surg. 2011;92:1826–32 (discussion 1832).

    Article  PubMed  Google Scholar 

  22. Dane B, Grechushkin V, Plank A, Moore W, Bilfinger T. PET/CT vs. non-contrast CT alone for surveillance 1-year post lobectomy for stage I non-small-cell lung cancer. Am J Nucl Med Mol Imaging. 2013;3:408–16.

    PubMed Central  PubMed  Google Scholar 

  23. Antoniou AJ, Marcus C, Tahari AK, Wahl RL, Subramaniam RM. Follow-up or surveillance 18F-FDG PET/CT and survival outcome in lung cancer patients. J Nucl Med. 2014;28:1062–8.

    Article  Google Scholar 

  24. Aokage K, Yoshida J, Nishimura M, Nishiwaki Y, Nagai K. Annual abdominal ultrasonographic examination after curative NSCLC resection. Lung Cancer. 2007;57:334–8.

    Article  PubMed  Google Scholar 

  25. Yanagawa N, Shiono S, Abiko M, Ogata SY, Sato T, Tamura G. New IASLC/ATS/ERS classification and invasive tumor size are predictive of disease recurrence in stage I lung adenocarcinoma. J Thorac Oncol. 2013;8:612–8.

    Article  PubMed  Google Scholar 

  26. Warth A, Muley T, Meister M, Stenzinger A, Thomas M, Schirmacher P, et al. The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of survival. J Clin Oncol. 2012;30:1438–46.

    Article  PubMed  Google Scholar 

  27. Asamura H, Goya T, Koshiishi Y, Sohara Y, Eguchi K, Mori M, et al. A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers. J Thorac Oncol. 2008;3:46–52.

    Article  PubMed  Google Scholar 

  28. McCunney RJ, Li J. Radiation risks in lung cancer screening programs: a comparison with nuclear industry workers and atomic bomb survivors. Chest. 2014;145:618–24.

    Article  PubMed  Google Scholar 

  29. Little MP. Cancer after exposure to radiation in the course of treatment for benign and malignant disease. Lancet Oncol. 2001;2:212–20.

    Article  CAS  PubMed  Google Scholar 

  30. Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of ct screening for lung cancer: a systematic review. JAMA. 2012;307:2418–29.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. Winton T, Livingston R, Johnson D, Rigas J, Johnston M, Butts C, et al. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med. 2005;352:2589–97.

    Article  CAS  PubMed  Google Scholar 

  32. Douillard JY, Rosell R, De Lena M, Carpagnano F, Ramlau R, Gonzales-Larriba JL, et al. Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial. Lancet Oncol. 2006;7:719–27.

    Article  CAS  PubMed  Google Scholar 

  33. Butts CA, Ding K, Seymour L, Twumasi-Ankrah P, Graham B, Gandara D, et al. Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10. J Clin Oncol. 2010;28:29–34.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  34. Arriagada R, Dunant A, Pignon JP, Bergman B, Chabowski M, Grunenwald D, et al. Long-term results of the international adjuvant lung cancer trial evaluating adjuvant Cisplatin-based chemotherapy in resected lung cancer. J Clin Oncol. 2010;28:35–42.

    Article  CAS  PubMed  Google Scholar 

  35. Borgelt B, Gelber R, Kramer S, Brady LW, Chang CH, Davis LW, et al. The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 1980;6:1–9.

    Article  CAS  PubMed  Google Scholar 

  36. Coia LR, Aaronson N, Linggood R, Loeffler J, Priestman TJ. A report of the consensus workshop panel on the treatment of brain metastases. Int J Radiat Oncol Biol Phys. 1992;23:223–7.

    Article  CAS  PubMed  Google Scholar 

  37. Nieder C, Grosu AL, Astner S, Thamm R, Molls M. Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors. Radiat Oncol. 2006;1:19.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Conflict of interest

None of the authors has any financial or other potential conflicts of interests to declare.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shigeki Sawada.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sawada, S., Shiono, S., Yamashita, Y. et al. A proposal of postoperative follow-up pathways for lung cancer. Gen Thorac Cardiovasc Surg 63, 231–238 (2015). https://doi.org/10.1007/s11748-014-0506-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11748-014-0506-7

Keywords

Navigation