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Can dehydrated human amnion/chorion membrane accelerate the return to potency after a nerve-sparing robotic-assisted radical prostatectomy? Propensity score-matched analysis

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Abstract

The objective of this study is to determine if the use of dehydrated human amnion/chorion membrane (dHACM) allograft wrapped around the NVB during a robotic-assisted radical prostatectomy (RARP) accelerates the return to potency. 940 patients with preoperative SHIM >20 underwent RARP with some degree of bilateral NS. Of these, 235 patients underwent RARP, with bilateral placement of dHACM graft around the NVBs. They were matched in a 1:3 proportion with a similar group of patients (n = 705) who did not receive the allograft (control group or group 2). Minimum follow-up was 12 months. Postoperative outcomes were analyzed between propensity-matched dHACM graft (group 1) and non-graft groups (group 2). Kaplan–Meier survival curves were compared across techniques using the log-rank test. There were no significant demographic differences between the two groups. Potency was defined as the ability to achieve and maintain satisfactory erections firm enough for sexual intercourse, with or without the use of PDE-5 inhibitors. The mean time to potency was significantly lower in group 1 (2.37 months) versus group 2 (3.94 months) (p < 0.0001). The potency recovery rates were superior for group 1 at all early time points measured except at 12 months. The time to potency was significantly shorter in the dHACM group with full NS, 2.19 ± 1.84 versus 2.78 ± 2.70 mo. in the non-dHACM with full NS (p = 0.029). In the dHACM group with partial NS, the mean time to potency was 3.05 ± 2.32 versus 3.92 ± 3.42 mo. in the non-dHACM with partial NS (p = 0.021). Patients who received the dHACM wrap around the NVB after RARP accelerates the return to potency when compared to a similar control group without the use of the allograft. We also demonstrated that this faster return to potency occurs regardless of the degree of the NS preservation. Younger patients (<55 years of age) had the highest overall advantage if they received the graft. Our results indicate that dHACM placement at the site of the prostatic NVB does not increase the risk of BCR after RARP, neither in the presence of PSM, extra-prostatic disease (≥pT3) nor high Gleason score (Gleason ≥8).

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Abbreviations

dHACM:

Dehydrated human amnion/chorion membrane

PCa:

Prostate cancer

RARP:

Robotic-assisted radical prostatectomy

NS:

Nerve spare

RP:

Radical prostatectomy

SHIM:

Sexual Health Inventory for Men

y.o:

Years old

mo.:

Months

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Authors and Affiliations

  1. Florida Hospital-Celebration Health, Urology, University of Central Florida School of Medicine and Global Robotics Institute, 410 Celebration Place, Suite 200, Celebration, FL, 34747, USA

    Gabriel Ogaya-Pinies, Hariharan Palayapalam-Ganapathi, Travis Rogers, Eduardo Hernandez-Cardona, Cathy Jenson & Vipul R. Patel

  2. University of Modena e Reggio Emilia, Modena, Italy

    Bernardo Rocco

  3. Hospital Israelita Albert Einstein, São Paulo, Brazil

    R. F. Coelho

Authors
  1. Gabriel Ogaya-Pinies
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  2. Hariharan Palayapalam-Ganapathi
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  3. Travis Rogers
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  4. Eduardo Hernandez-Cardona
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  5. Bernardo Rocco
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  6. R. F. Coelho
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  7. Cathy Jenson
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  8. Vipul R. Patel
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Corresponding author

Correspondence to Gabriel Ogaya-Pinies.

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Funding

The study was partially funded by MiMedx® (Marietta, GA, USA) who provided the grafts. Author Patel is a medical consultant for MiMedx®.

Conflict of interest

Ogaya-Pinies, Palayapalam-Ganapathi, Rogers, Hernandez-Cardona, Rocco, Coelho, Jenson, declare that they have no conflicts of interest.

Ethical approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5).

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Ogaya-Pinies, G., Palayapalam-Ganapathi, H., Rogers, T. et al. Can dehydrated human amnion/chorion membrane accelerate the return to potency after a nerve-sparing robotic-assisted radical prostatectomy? Propensity score-matched analysis. J Robotic Surg 12, 235–243 (2018). https://doi.org/10.1007/s11701-017-0719-8

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  • DOI: https://doi.org/10.1007/s11701-017-0719-8

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