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Body Composition, Serum Sclerostin and Physical Function After Bariatric Surgery: Performance of Dual-Energy X-ray Absorptiometry and Multifrequency Bioelectrical Impedance Analysis

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Abstract

Introduction

The aim of this study was to determine the effects of bariatric surgery and weight loss on body composition, serum sclerostin and physical performance.

Methods

Seventy-three consecutive patients (36 non-surgical controls and 37 who underwent bariatric surgery) were evaluated by means of laboratory tests, multifrequency bioelectrical impedance analysis (BIA), total-body dual-energy X-ray absorptiometry (DXA), gait speed and handgrip strength.

Results

The differences between non-surgical and surgical patients were as follows: body mass index (BMI) 42.9 ± 5.7 vs 34.8 ± 6.0 kg/m2 (p < 0.001); handgrip strength 31.3 ± 7.0 vs 27.1 ± 9.3 kg (p < 0.033); skeletal muscle mass index (SMI)-BIA 12.3 ± 1.2 vs 10.6 ± 1.2 kg/m2; fat-free mass index (FFMI)-BIA 21.9 ± 1.9 vs 18.9 ± 2.1 k/m2 (p < 0.001 for all comparisons); Baumgartner-DXA 10.8 ± 1.5 vs 9.0 ± 1.4 kg/m2 (p < 0.001); fat mass BIA 55.4 ± 12.5 vs 36.8 ± 9.6; fat mass DXA 54.3 ± 12.38 vs 35.1 ± 7.5 kg (p < 0.001 for both comparisons) and serum sclerostin 30.9 ± 31.9 vs 26.9 ± 21.1 pmol/L (p = 0.516). Positive correlation was found between BIA and DXA: SMI × Baumgartner (r = 0.842; p < 0.001) and fat mass (r = 0.970; p < 0.001). Gait speed was relatively preserved in sleeve gastrectomy (SG) compared with Roux-en-Y gastric bypass (RYGB) (1.2 ± 0.3 and 0.9 ± 0.1 m/s; p = 0.038).

Conclusion

Bariatric surgery leads to lower values of lean and fat mass and of handgrip strength with no differences in serum sclerostin concentrations. There was a positive correlation between BIA and DXA for fat and lean mass parameters. Physical performance was better after SG than in RYGB.

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Financial Support

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.

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Authors and Affiliations

  1. Division of Endocrinology and Diabetes, Hospital Agamenon Magalhães, University of Pernambuco Medical School, Recife, Brazil

    Paula Aragão Prazeres de Oliveira, Louise Rayra Alves Bezerra & Francisco Bandeira

  2. Instituto de Medicina Integral de Pernambuco (IMIP), Recife, Brazil

    Ana Carla Peres Montenegro

  3. Hospital Agamenon Magalhães, Estrada do Arraial, 2723, Recife, Brazil

    Louise Rayra Alves Bezerra

  4. Department of Nutrition, Federal University of Pernambuco, Recife, Brazil

    Maria da Conceição Chaves de Lemos

Authors
  1. Paula Aragão Prazeres de Oliveira
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  2. Ana Carla Peres Montenegro
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  3. Louise Rayra Alves Bezerra
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  4. Maria da Conceição Chaves de Lemos
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  5. Francisco Bandeira
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Corresponding author

Correspondence to Louise Rayra Alves Bezerra.

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Ethical Approval

The study was approved by the Institutional Ethics in Research Committee. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare that they have no conflict of interest.

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de Oliveira, P.A.P., Montenegro, A.C.P., Bezerra, L.R.A. et al. Body Composition, Serum Sclerostin and Physical Function After Bariatric Surgery: Performance of Dual-Energy X-ray Absorptiometry and Multifrequency Bioelectrical Impedance Analysis. OBES SURG 30, 2957–2962 (2020). https://doi.org/10.1007/s11695-020-04625-x

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