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Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis

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Abstract

We aim to review the available literature on obese patients treated with bariatric procedures, in order to assess their effect on the metabolic and gut microbiota profiles. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Twenty-two studies (562 patients) met the inclusion criteria. This study points to significant amelioration of postoperative levels of glucose, insulin, triglycerides, total cholesterol, LDL, HDL, HOMA-IR, food intake, and diabetes remission. Branched-chain amino acids (BCAAs) decreased, while trimethylamine-n-oxide (TMAO); glucagon-like peptide 1, 2 (GLP-1, GLP-2); and peptide YY (PYY) increased postoperatively. Postoperative gut microbiota was similar to that of lean and less obese objects. Well-designed randomized trials are necessary to further assess the host metabolic-microbial cross-talk after bariatric procedures.

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Authors and Affiliations

  1. Department of Surgery, University Hospital of Larissa, Larissa, Greece

    Dimitrios E. Magouliotis, Eleni Sioka & Dimitrios Zacharoulis

  2. School of Health Sciences, Faculty of Medicine, University of Thessaly, Viopolis, Larissa, Greece

    Vasiliki S. Tasiopoulou

  3. Department of Microbiology, University Hospital of Larissa, Larissa, Greece

    Christina Chatedaki

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  1. Dimitrios E. Magouliotis
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  2. Vasiliki S. Tasiopoulou
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  3. Eleni Sioka
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  4. Christina Chatedaki
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Correspondence to Dimitrios E. Magouliotis.

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Magouliotis, D.E., Tasiopoulou, V.S., Sioka, E. et al. Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis. OBES SURG 27, 1345–1357 (2017). https://doi.org/10.1007/s11695-017-2595-8

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