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Status of Iron Metabolism 10 Years After Roux-En-Y Gastric Bypass

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Abstract

Background

The aim of this study is to investigate changes in iron metabolism and verify whether biochemical parameters are related to the use of oral iron supplement 10 years after Roux-en-Y gastric bypass.

Methods

This longitudinal retrospective study included 151 patients submitted to Roux-en-Y gastric bypass. The collected data included use of an oral iron supplement, hemoglobin, hematocrit, serum iron, and ferritin. The chi-squared or Fisher’s exact test was used to analyze the association between use of iron supplement and nutritional deficiency. The generalized estimating equations (GEEs) analyzed the nutritional deficiencies over time.

Results

Of the study patients with iron-deficiency anemia (n = 15) in the 12-month follow-up, 73.33% (n = 11) were taking an iron supplement, and 26.67% (n = 4) were not (p = 0.0010). The effect of time was significant for hemoglobin, ferritin, iron overload (p < 0.0001), and hematocrit (p = 0.0007). Of the patients who remained in the study until the 120-month follow-up, 37.5 and 45.0% were diagnosed with iron-deficiency anemia, defined as ferritin <15 μg/L and ferritin <30 μg/L, respectively.

Conclusions

Iron-deficiency anemia increased over time even in patients taking oral iron supplements.

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Acknowledgments

We thank the Pontifical Catholic University of Campinas-SP-Brazil and the Coordination for the Improvement of Higher-education Personnel for the master’s scholarship provided to the Master’s Program in Health Sciences of Puc-Campinas-SP-Brazil.

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Authors and Affiliations

  1. Dietitian, Master of Health Sciences, Puc-Campinas, SP, Brazil

    Daniela Vicinansa Monaco-Ferreira

  2. Professor, Doctor of the Graduate Program in Health Sciences, Puc-Campinas, SP, Brazil

    Vânia Aparecida Leandro-Merhi

Authors
  1. Daniela Vicinansa Monaco-Ferreira
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  2. Vânia Aparecida Leandro-Merhi
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Corresponding author

Correspondence to Vânia Aparecida Leandro-Merhi.

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Statement of Authorship

DVMF conceived and designed the study, collected and analyzed data, and wrote the manuscript. VALM helped to conceive the study, supervised the research, and reviewed the manuscript. The authors read and approved the final version of the article.

Sponsor

This project was not sponsored.

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Does not apply. For this type of study formal consent is not required.

Additional information

Article based on the master’s dissertation of Daniela Vicinansa Monaco-Ferreira

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Monaco-Ferreira, D.V., Leandro-Merhi, V.A. Status of Iron Metabolism 10 Years After Roux-En-Y Gastric Bypass. OBES SURG 27, 1993–1999 (2017). https://doi.org/10.1007/s11695-017-2582-0

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