Abstract
Wilson disease (WD) can manifest with hepatic or neuropsychiatric symptoms. Our understanding of the in vivo brain changes in WD, particularly in the hepatic phenotype, is limited. Thirty subjects with WD and 30 age- and gender-matched controls participated. WD group underwent neuropsychiatric assessment. Unified WD Rating Scale neurological exam scores were used to determine neurological (WDN, score > 0) and hepatic-only (WDH, score 0) subgroups. All subjects underwent 3 Tesla anatomical and resting-state functional MRI. Diffusion tensor imaging (DTI) and susceptibility-weighted imaging (SWI) were performed only in the WD group. Volumetric, DTI, and functional connectivity analyses were performed to determine between-group differences. WDN and WDH groups were matched in demographic and psychiatric profiles. The entire WD group compared to controls showed significant thinning in the bilateral superior frontal cortex. The WDN group compared to control and WDH groups showed prominent structural brain changes including significant striatal and thalamic atrophy, more subcortical hypointense lesions on SWI, and diminished white matter integrity in the bilateral anterior corona radiata and corpus callosum. However, the WDH group also showed significant white matter volume loss compared to controls. The functional connectivity between the frontostriatal nodes was significantly reduced in the WDN group, whereas that of the hippocampus was significantly increased in the WDH group compared to controls. In summary, structural and functional brain changes were present even in neurologically non-manifesting WD patients in this cross-sectional study. Longitudinal brain MRI scans may be useful as biomarkers for prognostication and optimization of treatment strategies in WD.
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We thank the Wilson Disease Association for their help with participant recruitment.
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This study was supported through the grants from the Jack Levin Foundation, The Rachel and Drew Katz Foundation and the Albert Family to the Yale University School of Medicine.
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Study conceptualization and design: ST, DR, MLS, RTC. Data collection: KN, AVR, JA. Data analysis and interpretation: ST, JA, KN, AVR, MS, AP, RTC. Supervision of the study procedures: ST, DR, RTC, MLS. Drafting the manuscript: ST. All authors contributed to the final version of the manuscript.
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Tinaz, S., Arora, J., Nalamada, K. et al. Structural and functional brain changes in hepatic and neurological Wilson disease. Brain Imaging and Behavior 15, 2269–2282 (2021). https://doi.org/10.1007/s11682-020-00420-5
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