Abstract
Objective
To investigate the expressions of Beta-catenin, E-cadherin and MMP-7 and their implications in ovarian epithelial tumor.
Methods
Immunohistochemical staining with SP method was conducted to identify the expressions of Beta-catenin, E-cadherin and MMP-7 in ovarian epithelial tumor in 66 cases.
Results
The abnormal expression rate of Beta-catenin in malignant ovarian epithelial tumor was higher than those in borderline and benign epithelial tumors (P<0.05). The positive rates of E-cadherin in benign and borderline ovarian epithelial tumors were significantly greater than that in malignant epithelial tumor. The expression rates of MMP-7 in malignant and borderline ovarian epithelial tumors were higher than that in benign epithelial tumor (P<0.05).
Conclusion
The abnormal expressions of Beta-catenin, E-cadherin and MMP-7 might be used to indicate the malignance transform of ovarian epithelial tumors, but they have no significant correlation with peritoneal dropsy invasion, caul invasion and appendant invasion in ovarian epithelial tumor.
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References
Brabletz T, Jung A, Dag S, et al. Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer [J]. Am J Pathol 1999; 155:1033–1038.
Prange W, Breuhahn K, Fischer F, et al. Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes [J]. J Pathol 2003; 201:250–259.
Chiang JM, Chou YH, Chen TC, et al. Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma [J]. Br J Cancer 2002; 86:1124–1129.
Lee KH, Choi EY, Hyun MS, et al. Association of extracellular cleavage of E-cadherin mediated by MMP-7 with HGF-induced in vitro invasion in human stomach cancer cells [J]. Eur Surg Res 2007;39:208–215.
Wand WS, Chen PM, Hsiao HL, et al. Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma [J]. Oncogene 2004; 23:6666–6671.
Zhang MJ, Wang Q, Wang YH, et al. Immunohistochemical detection and clinical significance of beta-catenin expression in human colorectal cancer [J]. J Sec Mil Med Univ (in Chin) 2000; 21:239–241.
Shimizu M, Saitoh Y, Itoh H. Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissue [J]. Hum Pathol 1990; 21:607–612.
Lin X, Li Y, Mi C. The expression of beta-catenin, APC protein, c-myc and cyclin D1 in ovarian epithelial tumor and their implication [J]. Chin J Cancer Res 2007; 19:131–135.
Brabletz T, Jung A, Dag S, et al. Beta-catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma [J]. Verh Dtsch Ges Pathol 2000; 84:175–181.
Ougolkov AV, Yamashita K, Mai M, et al. Oncogenic beta-catenin and MMP-7 (matrilysin) cosegregate in late-stage clinical colon cancer [J]. Gastroenterology 2002; 122:60–71.
Shigemasa K, Tanimoto H, Sakata K, et al. Induction of matrix metalloprotease-7 is common in mucinous ovarian tumors including early stage disease [J]. Med Onol 2007; 17:52–58.
Wang FQ, So J, Reierstad S, et al. Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase [J]. Int J Cancer 2005;114:19–31.
Guo Y, Liu J, Wu J, et al. Expression of matrix metalloproteinase-7 in serous ovarian tumors [J]. Chin J Cell Mol Immunol (in Chin) 2002;18:471–473.
Zhai Y, Wu R, Schwartz DR, et al. Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas [J]. Am J Pathol 2002; 160:1229–1238.
Huiping C, Kristjansdottir S, Jonasson JG, et al. Alterations of E-cadherin and beta-catenin in gastric cancer [J]. BMC Cancer 2001; 1:16.
Wong AS, Maines-Bandiera SL, Rosen B, et al. Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: influence of family history of ovarian cancer [J]. Int J Cancer 1999; 81:180–188.
Hu XX, Li L, Li DR, et al. Expression of matrix metalloproteinases-7 and tissue inhibitor of metalloproteinase-3 in ovarian tumors [J]. Gungxi Med J (in Chin) 2006; 28:329–332.
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This work was supported by the Scientific Research Start Found of Chongqing Medical University (No.QD200201) and Project of Chongqing Science and Technology Committee (No.040307).
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Lin, X., Li, Y. & Mi, C. Expressions of Beta-catenin, E-cadherin and MMP-7 in ovarian epithelial tumors. Chin. J. Cancer Res. 20, 190–193 (2008). https://doi.org/10.1007/s11670-008-0190-1
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DOI: https://doi.org/10.1007/s11670-008-0190-1