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Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial

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Abstract

Objective

To assess the effect of valerian root extract on the sleep quality of patients after coronary artery bypass graft (CABG) surgery.

Methods

The patients who participated in this triple-blind clinical trial were selected by permuted block randomization. The participants were assigned to the valerian (n=36) and placebo (n=36) groups. The valerian group received 530 mg of valerian capsules for 30 nights after CABG surgery, and the placebo group received 530 mg of the placebo capsules containing wheat flour. The Pittsburgh Sleep Quality Index (PSQI), the prothrombin time (PT) and partial thromboplastin time (PTT) were assessed on four occasions, including the baseline, the 3rd, 14th and 30th days following intervention.

Results

The odds ratio of worsened sleep quality significantly varied over time (the interaction of time and group) in the valerian group compared to the placebo group in various dimensions including total sleep quality (P=0.001), sleep latency (P<0.01), sleep duration (P=0.020), sleep efficiency (P=0.001) and daytime dysfunction (P=0.025). No significant difference was observed in the alterations of the odds ratio of PT in the two groups over time. (P=0.371).

Conclusion

The consumption of oral valerian root extract over 30 nights could significantly improve the patients' sleep quality safely after CABG surgery.

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Acknowledgments

We are grateful to our participants. We thank Ali Pooria, cardiac surgeon, for his support and guidance of this study.

Author information

Authors and Affiliations

  1. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, 6814993165, Iran

    Halimeh khaton Zare Elmi

  2. School of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, 6814993165, Iran

    Mohammad Gholami

  3. Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, 6814993165, Iran

    Mandana Saki

  4. Department of Biostatistics and Epidemiology, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, 6814993165, Iran

    Farzad Ebrahimzadeh

Authors
  1. Halimeh khaton Zare Elmi
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  2. Mohammad Gholami
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  3. Mandana Saki
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  4. Farzad Ebrahimzadeh
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Contributions

Zare Elmi HK, Gholami M, Saki M, Ebrahimzadeh F designed the study. FE Ebrahimzadeh F, analyzed the data, and all authors contributed both to subsequent analyses and the writing of the study. All authors confirmed the final version of the manuscript.

Corresponding author

Correspondence to Mohammad Gholami.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Conflict of Interest

Supported by the Research and Technology Deputy of Lorestan University of Medical Sciences (No. A-10-1510-4)

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Zare Elmi, H.k., Gholami, M., Saki, M. et al. Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial. Chin. J. Integr. Med. 27, 7–15 (2021). https://doi.org/10.1007/s11655-020-2727-1

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  • DOI: https://doi.org/10.1007/s11655-020-2727-1

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