Skip to main content
Log in

Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine

  • Clinical Experience
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objective

To observe the influence of traditional Chinese medicine (TCM) therapy for supplementing Pi (脾) and nourishing Shen (肾, SPNS) on dendritic cell function in patients with chronic hepatitis B (CHB) treated by lamivudine.

Methods

Sixty CHB patients with positive HBeAg were equally randomized by digital table into two groups: the observation group and the control group. Patients in the control group were treated with lamivudine only, while patients in the observation group were treated with lamivudine combined with SPNS fomula, for 12 weeks. The phenotype and function of dendritic cell, as well as its secretion factor interleukin 12 (IL-12) in all patients were determined after termination of therapy and the impacts on alanine transaminase (ALT) and HBVDNA were observed.

Results

The phenotypes of dendritic cells such as CD1a, CD80, CD86, human leukocyte antigen (HLA-DR) and intercellular adhesion molecule-1, as well as the levels of stimulation index (SI) and IL-12 were higher in the observation group than those in the control group (P<0.05 or P<0.01). Meanwhile, signififi cant difference between the two groups was also shown in the normalizing rates of ALT and HBV-DNA (P<0.05).

Conclusion

TCM therapy for SPNS can signifificantly improve the function of dendritic cells in patients with CHB treated by lamivudine and enhance the early stage response of patients to the treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Van der Molen RG, Sprengers D, Binda RS, de Jong EC, Niesters HG, Kusters JG, et al. Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B. Hepatology 2004;40:738–746.

    Article  PubMed  Google Scholar 

  2. Chinese Society of Liver Disease and Infectious Diseases, Chinese Medical Association. Guidance for prevention and treatment of chronic hepatitis B. Chin J Hepatol (Chin) 2005;13:881–891.

    Google Scholar 

  3. Romani N, Gruner S, Brang D, Kämpgen E, Lenz A, Trockenbacher B, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994;180:83–93.

    Article  PubMed  CAS  Google Scholar 

  4. Shao P, Zhao LH. Regulation on phenotypic and functional maturation of dendritic cells by Astragalus mongholicus polysaccharides. Chin J Micro Immun (Chin) 2006; 26:637–640.

    CAS  Google Scholar 

  5. Luo HS, Luo BH. Immune pharmacology and clinic of traditional Chinese medicine. Bejing: Chinese Academy of Medical Sciences and Peking Union Medical College Press, 1999:87.

    Google Scholar 

  6. Paulesu L, Bocci V, King A, Loke YM. Immunocytochemical localization of interferons in human trophoblast populations. J Biol Regul Homeost Agents 1991;5:81–85.

    PubMed  CAS  Google Scholar 

  7. Qiu DK, Jing DD, Xiao SD, Zeng MD, Li JQ. Study on the effects of Cordycep polysaccharide-liposome in modulating T cell immunity in patients with post-hepatitic cirrhosis. Chin J Dig (Chin) 1995;5:265–268.

    Google Scholar 

  8. Li YG, Luo YP, Liang ZW, Ren H. Antigen presenting role of dendritic cell proliferated from peripheral blood monocytes in patients with chronic hepatitis B. Chin J Hepatol (Chin) 2000;8:330–331.

    CAS  Google Scholar 

  9. Li RB, Chen HS, Fei R, Cong X, Sun J, Wei L, et al. Functions of cultured dendritic cells from patients with chronic hepatitis B. Natl Med J Chin (Chin) 2002;82:887–891.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yi-hui Liu  (刘肄辉).

Additional information

Supported by General Scientific Research Development Projects of Science and Technology Department of Zhejiang Province (No. 2006C33007)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, Yh., Liu, Yh. Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine. Chin. J. Integr. Med. 15, 60–62 (2009). https://doi.org/10.1007/s11655-009-0060-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-009-0060-6

Key Words

Navigation