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Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer

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Abstract

Objective

To study the effects of Jianpi Qingre Huayu Recipe (健脾清热化瘀方, JQH) in curing gastric ulcer and to preliminarily probe into its pathogenic mechanism.

Methods

Fifty patients with gastric ulcer of Pi (脾)-insufficiency and stasis-heat syndrome type were assigned to the treated group (30 patients) and the control group (20 patients). They were treated respectively with JQH and Ranitidine. At the same time, another group consisting of 20 healthy persons was set up for normal control. The clinical effect on gastroscopic figure and traditional Chinese medicine (TCM) syndrome were observed. Changes of T-cell subsets and interleukin-8 (IL-8) in serum as well as IL-8 in mucosa around the gastric ulcer were determined before and after treatment by flow cytometry and ELISA.

Results

Comparison of the total effective rate on gastroscopic figure in the treated group and the control group (86.7% vs 80.0%) showed insignificant difference, but the cure rate and markedly effective rate in the former (50.0% and 20.0%) was higher than that in the latter (40.0% and 15.0%) respectively. Comparison of the total effective rate on TCM syndrome in the treated group and in the control group (96.7% vs 70.0%) showed insignificant difference, but the cure rate and markedly effective rate in the former (63.3% and 23.3%) was higher than that in the latter (50.0% and 20.0%) respectively. Serum levels of CD3 +, CD4 +, CD8 + got restored to normal range in the treated group after treatment but it was not so in the control group. IL-8 level in gastric mucosa was improved in both groups but the improvement in the treated group was better.

Conclusion

JQH could effectively treat gastric ulcer and partly reduce its recurrence through improving patients’ immune function.

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References

  1. Wang ZT, Dong GL, Wang WZ. The effects of Kang Lai-te on apoptosis and proliferation of advanced gastric cancer patients. Chin J Cell Mol Immun 2002;18(5):463–465.

    Google Scholar 

  2. Committee of New Drug of Traditional Chinese Drugs Clinical Study Instruction Principle. New drug of traditional Chinese clinical study instruction principle. Beijing: People’s Medical Publishing House, 2002:123–125.

    Google Scholar 

  3. Guangxi Medical Science Information Institute. Standard of diseases diagnosis and treatment. Nanning: Guangxi People’s Medical Publishing House, 1993:606.

    Google Scholar 

  4. Xu GM, Li ZS. Training textbook of endoscope. Shanghai: Shanghai Sience and Technology Publishing Company, 2002:115–118.

    Google Scholar 

  5. Zheng QJ, Cai ZJ, Yu SQ, et al. Effect of FK506 combinated with resveratrol on T-cell subsets and its ummune function following homologous heart transplantation. China J Mordern Med 2005;15(20):3099–3101.

    Google Scholar 

  6. Gao SP, Tang HJ, Jia XH, et al. The effect of immunity of Prescription Runing II to breast cance surgery patients and mouse with cancer. Chin J Tradit Med Sci Technol 2003;10(5):261–262.

    Google Scholar 

  7. Zhang XN. Treatment method of replenishment Pi to prevent “easy to suffer from a disease”. Liaoning J Tradit Chin Med 1993;4(1):29.

    Google Scholar 

  8. Huang SG, Zhou FS, Wang RJ, et al. A study of traditional Chinese medicine pathogen of gastric ulcer and recurrence. New J Tradit Chin Med 2005;37(3):6–7.

    Google Scholar 

  9. Wu XC, Du SL, Cheng HS. Study and application of Dandelion herb. J Pharm Practice 2002;20(4):246–248.

    Google Scholar 

  10. Wang GM, Ma XQ. Clinic application of Red sage root. China’s Naturopathy 2003;11(12):51–52.

    Google Scholar 

  11. Zhou FS, Hu L, Cui QZ, et al. A mechanic study of traditional Chinese medicine in treating ulcer recurrence. Chin J Integr Tradit West Med 2001;21(3):231–234.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Pi-wei Institute of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405, China

    Zhou Fu-sheng  (周福生), Wang Ru-jun  (王汝俊), Huang Zhi-xin  (黄志新) & Luo Qi  (罗琦)

  2. Guangzhou University of Traditional Chinese Medicine, China

    Hu Li-Juan  (胡丽娟)

Authors
  1. Zhou Fu-sheng  (周福生)
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  2. Hu Li-Juan  (胡丽娟)
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  3. Wang Ru-jun  (王汝俊)
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  4. Huang Zhi-xin  (黄志新)
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  5. Luo Qi  (罗琦)
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Corresponding author

Correspondence to Zhou Fu-sheng  (周福生).

Additional information

Supported by Guangdong Provincial Committee of Science and Technology, Project number 6

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Zhou, Fs., Hu, LJ., Wang, Rj. et al. Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer. Chin. J Integ. Med. 13, 22–26 (2007). https://doi.org/10.1007/s11655-007-0022-z

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  • DOI: https://doi.org/10.1007/s11655-007-0022-z

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