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A preoperative nomogram for predicting the risk of sentinel lymph node metastasis in patients with T1-2N0 breast cancer

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Objectives

To establish a preoperative nomogram based on the multimodal ultrasonographic features and biopsy results of primary lesion to predict the risk of sentinel lymph node metastasis (SLNM) in patients with T1-2N0 breast cancer.

Methods

This study included 114 patients with T1-2N0 breast cancer who underwent ultrasound-guided core needle biopsy and multimodal ultrasound (Gray scale, Elastography, and Contrast-enhanced ultrasound) preoperatively. The pathological results of SLN were obtained from sentinel lymph node biopsy. Factors associated with sentinel lymph node metastasis were studied.

Results

The regression analysis identified the maximum diameter of tumor (p = 0.003), Doppler resistive index (p = 0.030), HER-2 status (p = 0.016) and the extended range of enhancement lesion (p = 0.010), which were used to establish a nomogram. The prediction model indicated that the value of area under the receiver-operating characteristic curve was 0.798. The calibration curve revealed that the nomogram possesses an excellent consistency between the predicted value and the actual value of SLNM (Hosmer–Lemeshow test: p = 0.436).

Conclusions

The preoperative nomogram can effectively guide clinicians in predicting SLNM of breast cancer, and assist management of breast cancer patients through intuitive risk values to develop personalized treatment strategies.

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Acknowledgements

This work was supported by Gansu Province Science and Technology Plan Project (Nos.: 21YF5FA122, 20JR10FA664).

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Correspondence to Fang Nie.

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The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Zhu, Y., Lv, W., Wu, H. et al. A preoperative nomogram for predicting the risk of sentinel lymph node metastasis in patients with T1-2N0 breast cancer. Jpn J Radiol 40, 595–606 (2022). https://doi.org/10.1007/s11604-021-01236-z

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  • DOI: https://doi.org/10.1007/s11604-021-01236-z

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