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Bioinformatics-based Identification of Key Pathways and Hub Genes of Traumatic Brain Injury in a Rat Model

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Summary

Traumatic brain injury (TBI) is a common injury caused by external forces that lead to damaged brain function or pathological changes in the brain tissue. To explore the molecular mechanism and the hub genes of TBI, we downloaded gene expression profiles of the TBI model of rat and the sham control for the subsequent gene set enrichment analysis, pathway analysis and protein-protein interactions analysis. The results of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis indicated that multiple biological pathways, including immune response, inflammatory response and cellular response to interleukin-1, as well as signaling pathways, such as tumor necrosis factor signaling pathway, chemokine signaling pathway, cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway and nuclear factor kappa B signaling pathway were implicated in the TBI. In conclusion, this study provides insights into the molecular mechanism of TBI by screening the differentially expressed genes and hub genes that can be used as biomarkers and therapeutic targets.

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Authors and Affiliations

  1. Wuxi Clinical College of Anhui Medical University (904th Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army), Wuxi, 214000, China

    Xin-yi Cao, Xiao Qian, Guo-dong Liu & Yu-hai Wang

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  1. Xin-yi Cao
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  2. Xiao Qian
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  3. Guo-dong Liu
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  4. Yu-hai Wang
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Correspondence to Yu-hai Wang.

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This work was supported by the Military Logistics Scientific Research Project (No. CLB20J027).

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Cao, Xy., Qian, X., Liu, Gd. et al. Bioinformatics-based Identification of Key Pathways and Hub Genes of Traumatic Brain Injury in a Rat Model. CURR MED SCI 41, 610–617 (2021). https://doi.org/10.1007/s11596-021-2365-7

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  • DOI: https://doi.org/10.1007/s11596-021-2365-7

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