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Genetic Variants in EGFR/PLCE1 Pathway Are Associated with Prognosis of Esophageal Squamous Cell Carcinoma after Radical Resection

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Summary

Esophageal cancer (EC) is one of the most deadly malignant diseases. Several studies revealed that variations of the phospholipase C epsilon 1 (PLCE1) gene were associated with EC susceptibility. PLCE1 is located downstream of the epidermal growth factor receptor (EGFR) pathway. Presently, the single nucleotide polymorphisms (SNPs) of EGFR/PLCE1 genes and their associations with EC survival remain unclear. In this study, the associations between genetic variants in the EGFR/PLCE1 pathway and prognosis in 124 esophageal squamous cell carcinoma (ESCC) patients with radical resection were explored. The results showed that CC genotype of both PLCE1 rs17109671 and EGFR rs2072454 was associated with ESCC prognosis. Multivariate analysis revealed that patients with the two unfavorable genotypes had the worst overall survival (OS) or disease-free survival (DFS) (HR=6.099, 95%CI=1.903–19.552; HR=3.994, 95%CI=1.49–10.702, respectively). Additionally, combination of SNPs and tumor stage could better predict OS (for AUC, 0.774 vs. 0.709) and PFS (for AUC, 0.773 vs. 0.704) than tumor stage alone. In conclusion, genetic variants of the EGFR/PLCE1 may be predictors of the prognosis of ESCC after surgery. The individuals with the CC genotype of PLCE1 rs17109671 and EGFR rs2072454 should receive more aggressive treatments.

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Author notes

  1. The authors contributed equally to this work.

Authors and Affiliations

  1. Department of Oncology, the First Affiliated Hospital of the Medical College, Shihezi University, Shihezi, 832008, China

    Yu-li Wang & Ping Gong

  2. Department of Clinical Medicine, School of Medicine, Shihezi University, Shihezi, 832008, China

    Ye Yuan

  3. Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xiao-xiao Luo & Guang-yuan Hu

Authors
  1. Yu-li Wang
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  2. Ye Yuan
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  3. Xiao-xiao Luo
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  4. Guang-yuan Hu
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  5. Ping Gong
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Corresponding authors

Correspondence to Guang-yuan Hu or Ping Gong.

Additional information

This work was supported by the Double First-Class Construction Project (No. 540-5001540067), and the Construction of Information Resources Database in Tumor Multi-omics and Multi-beam Project (No. 2016YFC0904701).

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Wang, Yl., Yuan, Y., Luo, Xx. et al. Genetic Variants in EGFR/PLCE1 Pathway Are Associated with Prognosis of Esophageal Squamous Cell Carcinoma after Radical Resection. CURR MED SCI 39, 385–390 (2019). https://doi.org/10.1007/s11596-019-2047-x

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  • DOI: https://doi.org/10.1007/s11596-019-2047-x

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