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Effect of ovariectomy on serum adiponectin levels and visceral fat in rats

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Summary

This study was aimed to examine the effect of ovariectomy on visceral fat, serum adiponectin levels and lipid profile. Forty-five female Sprague Dawley rats were divided into three groups (n=15 each): ovariectomized group (OVX), ovariectomized plus estrogen-treated group (OVX+E2), and sham-operated group (SHAM). Body weight, abdominal adipose tissues, serum adiponectin and lipid profile were measured and compared among the groups after three-month feeding post-surgery. Significant increases in body weight and visceral fat were found in ovariectomized rats when compared with sham-operated ones and significant increases were also observed in serum adiponectin, triglyceride and very low density lipoprotein cholesterol levels in ovariectomized rats. Body weight, visceral fat and serum adiponectin levels were profoundly reduced in OVX+E2 group as compared with OVX group. It was concluded that ovarian hormone deficiency induced by ovariectomy leads to significant increases in body weight and visceral fat, along with increased serum adiponectin, triglyceride and very low density lipoprotein cholesterol levels in rats. Attenuation in these changes can be achieved by estrogen supplementation.

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Authors and Affiliations

  1. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ce Camara, Lin-yuan Zhou  (周林远), Yan Ma  (马 炎), Lin Zhu  (朱 琳), Dong Yu  (于 东), Yao-wu Zhao  (赵要武) & Nian-hong Yang  (杨年红)

  2. Key Lab of Environment and Health of the Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Dong Yu  (于 东), Yao-wu Zhao  (赵要武) & Nian-hong Yang  (杨年红)

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  1. Ce Camara
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  2. Lin-yuan Zhou  (周林远)
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  3. Yan Ma  (马 炎)
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  4. Lin Zhu  (朱 琳)
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  5. Dong Yu  (于 东)
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  6. Yao-wu Zhao  (赵要武)
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  7. Nian-hong Yang  (杨年红)
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Corresponding author

Correspondence to Nian-hong Yang  (杨年红).

Additional information

This work was supported by grants from the National Natural Science Foundation of China (No. 30671765) and Scientific Research Foundation for Returned Overseas Chinese Scholars, Ministry of Education of China (No. 20101561).

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Camara, C., Zhou, Ly., Ma, Y. et al. Effect of ovariectomy on serum adiponectin levels and visceral fat in rats. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 34, 825–829 (2014). https://doi.org/10.1007/s11596-014-1360-7

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  • DOI: https://doi.org/10.1007/s11596-014-1360-7

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