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Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease

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Summary

This study compared the efficacy and safety of tiotropium bromide inhalation powder (spiriva) and doxofylline oral tablet (doxofylline) in the treatment of chronic obstructive pulmonary disease (COPD). A multi-center, randomized, double-blind, double-dummy, parallel-controlled study involved 127 eligible stable moderate to severe COPD patients treated with inhaled tiotropium dry powder (18 μg/day) or oral doxofylline tablets (0.2 g/time, 2 times a day) for 12 and 24 weeks. Before and after treatment for 12 weeks and 24 weeks, respectively, pulmonary function, 6-min walking distance and dyspnea index were recorded. The results showed that in both tiotropium group and doxofylline groups, after 12-week treatment, FEV1, FEV1/FVC% and 6-min walk distance were significantly higher than those before the medication, while dyspnea index decreased as compared with that before treatment. After 24-week treatment, a slight improvement in the measures was observed as compared with that of 12-weeks treatment, but the difference was not statistically significant. With both 12-week and 24-week treatment, the effect of tiotropium was slightly better than that of doxofylline tablets, with the difference being statistically insignificant. The major adverse events in the tiotropium group and doxofylline group were observed in 9 cases (9.9%) and 12 cases (12.9%), respectively, and no statistically significant difference was found between them. We are led to conclude that both tiotropium at 18 μg a day and doxofylline tablets at 0.2 g/day (two times a day) are effective and safe for the treatment of COPD.

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References

  1. Raherison C, Girodet PO. Epidemiology of COPD. Eur Respir Rev, 2009,18(114):213–221

    Article  PubMed  CAS  Google Scholar 

  2. Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med, 2001,163(5):1256–1276

    PubMed  CAS  Google Scholar 

  3. Vagaggini B, Nieri D, Malagrinò L, et al. Acute administration of bronchodilators on exercise tolerance in treated COPD patients. Pulm Pharmacol Ther, 2011,24(1):49–54

    Article  PubMed  CAS  Google Scholar 

  4. Kaplan A. Effect of tiotropium on quality of life in COPD: a systematic review. Prim Care Respir J, 2010,19(4): 315–325

    Article  PubMed  Google Scholar 

  5. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: NHLBI/WHO workshop report. Available at: www.goldcopd.com. Accessed February 8, 2006.

  6. Chen AM, Bollmeier SG, Finnegan PM. Long-acting bronchodilator therapy for the treatment of chronic obstructive pulmonary disease. Ann Pharmacother, 2008, 42(12):1832–1842

    Article  PubMed  CAS  Google Scholar 

  7. Hanania NA, Sharafkhaneh A. Update on the pharmacologic therapy for chronic obstructive pulmonary disease. Clin Chest Med, 2007,28(3):589–607

    Article  PubMed  Google Scholar 

  8. Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J, 2002; 19(2):217–224

    Article  PubMed  CAS  Google Scholar 

  9. Vincken W, van Noord JA, Greefhorst AP, et al. Improved health outcomes in patients with COPD during 1 year’s treatment with tiotropium. Eur Respir J, 2002,19(2): 209–216

    Article  PubMed  CAS  Google Scholar 

  10. O’Donnell DE, Fluge T, Gerken F, et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J, 2004,23(6):832–840

    Article  PubMed  Google Scholar 

  11. Wang QY, Zhang H, Wang XQ, et al. Randomized double- blind double-dummy controlled clinical trial of tiotropium bromide in the treament of chronic obstructive pulmonary disease. Chin J Clin Pharmacol, 2005,21(5): 328–331

    Google Scholar 

  12. Zhang JP, Kang J, Cai BQ, et al. Comparsion of tiotropium inhalation capcules and ipratropium metered dose inhaler in a randomized, double-blind, double-dummy, efficacy and safety study in patients with chronic obstructive pulmonary disease. Chin J Tuberc Respir Dis, 2006, 29(6):363–367

    Google Scholar 

  13. Culpitt SV, de Matos C, Russell RE, et al. Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2002,165(10): 1371–1376

    Article  PubMed  Google Scholar 

  14. Barnes PJ. Theophylline: new perspectives for an old drug. Am J Respir Crit Care Med, 2003,167(6):813–818

    Article  PubMed  Google Scholar 

  15. Zhou YM, Wang XP, Zeng XY, et al. Theophylline in the treatment of chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study. Chin J Tuberc Respir Dis, 2006,29(9):577–582

    Google Scholar 

  16. Goldstein MF, Chervinsky P. Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma: a double-blind randomized placebo-controlled muhieentre clinical trial. Med Sci Monit, 2002,8(4): CR297–CR304

    PubMed  CAS  Google Scholar 

  17. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med, 2009,3(3):211–220

    Article  PubMed  CAS  Google Scholar 

  18. Tashkin DP. Long-acting anticholinergic use in chronic obstructive pulmonary disease: efficacy and safety. Curr Opin Pulm Med, 2010,16(2):97–105

    Article  PubMed  CAS  Google Scholar 

  19. Troosters T, Celli B, Lystig T, et al. Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT trial. Eur Respir J, 2010,36(1):65–73

    Article  PubMed  CAS  Google Scholar 

  20. Michele TM, Pinheiro S, Iyasu S. The safety of tiotropium—the FDA’s conclusions. N Engl J Med, 2010, 363(12):1097–1099

    Article  PubMed  CAS  Google Scholar 

  21. Littner MR, Ilowite JS, Tashkin DP, et al. Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2000,161(4 Pt 1):1136–1142

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China

    Tao Wang  (汪 涛), Jing Ma  (马 静), Jianmiao Wang  (王坚苗), Peng Zuo  (左 鹏), Weining Xiong  (熊维宁), Xiansheng Liu  (刘先胜), Jianping Zhao  (赵建平), Shengdao Xiong  (熊盛道), Zhenxiang Zhang  (张珍祥) & Yongjian Xu  (徐永健)

  2. Department of Respiratory Medicine, Wuhan First Hospital, Wuhan, 430022, China

    Guangwei Luo  (罗光伟) & Jiemin Sun  (孙洁民)

  3. Department of Respiratory Medicine, Wuhan Second Hospital, Wuhan, 430014, China

    Yi Hu  (胡 轶) & Su Zhao  (赵 苏)

  4. Department of Respiratory Medicine, Wuhan Sixth Hospital, Wuhan, 430015, China

    Fajiu Li  (李发久) & Chenghong Li  (李承红)

Authors
  1. Tao Wang  (汪 涛)
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  2. Guangwei Luo  (罗光伟)
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  3. Yi Hu  (胡 轶)
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  4. Fajiu Li  (李发久)
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  5. Jing Ma  (马 静)
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  6. Jianmiao Wang  (王坚苗)
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  7. Peng Zuo  (左 鹏)
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  8. Weining Xiong  (熊维宁)
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  9. Xiansheng Liu  (刘先胜)
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  10. Jianping Zhao  (赵建平)
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  11. Shengdao Xiong  (熊盛道)
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  12. Zhenxiang Zhang  (张珍祥)
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  13. Chenghong Li  (李承红)
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  14. Su Zhao  (赵 苏)
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  15. Jiemin Sun  (孙洁民)
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  16. Yongjian Xu  (徐永健)
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Corresponding author

Correspondence to Yongjian Xu  (徐永健).

Additional information

This project was supported by grants from the Clinical Chronic Respiratory Diseases Research Foundation of Chinese Medical Association (No. 07010030011), Key Research Program of the Ministry of Health of China (No. 2007353), the Special Funds for Scientific Research on Public Causes of Ministry of Health of China (No. 201002008).

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Wang, T., Luo, G., Hu, Y. et al. Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 614–618 (2011). https://doi.org/10.1007/s11596-011-0570-5

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  • DOI: https://doi.org/10.1007/s11596-011-0570-5

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