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Expression of MMP-9 and TIMP-1 in lesions of systemic sclerosis and its implications

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Summary

In order to investigate the role of MMP-9 and TIMP-1 in the pathogenesis of systemic sclerosis, the expression of MMP-9 and TIMP-1 was immunohistochemically detected in skin lesions of the patients with diffuse cutaneous systemic sclerosis, skin lesions of the patients with limited cutaneous systemic sclerosis, and skin tissues of normal subjects. The results showed that the expression of MMP-9 in lesions of diffuse cutaneous systemic sclerosis was significantly lower than that of normal skins (P<0.05). However, no significant difference in the level of MMP-9 in the limited cutaneous systemic sclerosis and normal skin was found. Meanwhile, the expression of TIMP-1 in lesions of diffuse cutaneous systemic sclerosis and limited cutaneous systemic sclerosis were significantly higher than that of normal skins (both P<0.05). It was suggested that the expression of MMP-9 and TIMP-1 might play an important role in the development of systemic sclerosis.

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Authors and Affiliations

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan, 430022, China

    Chi Meng  (孟 赤), Jiawen Li  (李家文), Yan Wu  (吴 艳) & Houjun Liu  (刘厚君)

  2. Department of Dermatology, Guizhou Provincial People’s Hospital, Guiyang, 550002, China

    Xu’e Chen  (陈旭娥)

Authors
  1. Chi Meng  (孟 赤)
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  2. Xu’e Chen  (陈旭娥)
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  3. Jiawen Li  (李家文)
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  4. Yan Wu  (吴 艳)
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  5. Houjun Liu  (刘厚君)
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Corresponding author

Correspondence to Chi Meng  (孟 赤).

Additional information

Chi MENG, female, born in 1981, Doctor in Charge

This project was supported by a grant from the Natural Science Fund of Wuhan City.

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Meng, C., Chen, X., Li, J. et al. Expression of MMP-9 and TIMP-1 in lesions of systemic sclerosis and its implications. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 28, 480–482 (2008). https://doi.org/10.1007/s11596-008-0424-y

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  • DOI: https://doi.org/10.1007/s11596-008-0424-y

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