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Preliminary clinical study of real-time three-dimensional echocardiographic volume-time curve in evaluating left ventricular diastolic function

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Summary

The volume-time curve change in patients with normal left ventricular (LV) diastolic function and diastolic dysfunction was evaluated by real-time three-dimensional echocardiography (RT3DE). LV diastolic dysfunction was defined by E′<A′ in pulse-wave tissue Doppler for inter-ventricular septal (IVS) of mitral annulus. In 24 patients with LV diastolic dysfunction, including 12 patients with delayed relaxation (delayed relaxation group) and 12 patients with pseudo-normal function (pseudo-normal group) and 24 normal volunteers (control group), data of full-volume image were acquired by real-time three-dimensional echocardiography and subjected to volume-time curve analysis. EDV (end-diastolic volume), ESV (end-systolic volume), LVEF (left ventricular ejection fraction), PER (peak ejection rate), PFR (peak filling rate) from RT3DE were examined in the three groups. Compared to the control group, PFR (diastolic filling index of RT3DE) was significantly reduced in the delayed relaxation group and pseudo-normal group (P<0.05). There were no significant differences in EDV, ESV, LVEF, PER (P>0.05). It is concluded that PFR, as a diastolic filling index of RT3DE, can reflect the early diastolic function and serve as a new non-invasive, quick and accurate tool for clinical assessment of LV diastolic function.

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Authors and Affiliations

  1. Department of Cardiology, Guangdong Provincial Institute of Cardiovascular Diseases, Guangdong Provincial People’ Hospital, Guangzhou, China, 510100

    Fei Hongwen  (费洪文), He Yale  (何亚乐), Hou Yueshuang  (侯跃双), Xu Yan  (许 燕), Huang Xinsheng  (黄新胜) & Feng Bixia  (冯碧霞)

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  1. Fei Hongwen  (费洪文)
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  2. He Yale  (何亚乐)
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  3. Hou Yueshuang  (侯跃双)
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  4. Xu Yan  (许 燕)
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  5. Huang Xinsheng  (黄新胜)
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  6. Feng Bixia  (冯碧霞)
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Corresponding author

Correspondence to Fei Hongwen  (费洪文).

Additional information

FEI Hongwen, male, born in 1974, M.D., Ph.D.

This project was supported by a grant from Guangdong Provincial Natural Sciences Foundation (No. 05300738).

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Fei, H., He, Y., Hou, Y. et al. Preliminary clinical study of real-time three-dimensional echocardiographic volume-time curve in evaluating left ventricular diastolic function. J. Huazhong Univ. Sc. Technol. 27, 475–478 (2007). https://doi.org/10.1007/s11596-007-0433-2

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  • DOI: https://doi.org/10.1007/s11596-007-0433-2

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