Skip to main content
SpringerLink
Log in

Surface properties of nano-Al2O3 film and its application in the preparation of morphine electrochemical sensor

  • Original Paper
  • Published:
Ionics Aims and scope Submit manuscript

Abstract

In this study, alumina nanoparticles and film were synthesized by sol–gel method and thermally grown. The chemical composition, morphology, and structural properties of the grain nanostructures of the nanoaggregate aluminum atoms on the silicon surface are characterized by X-ray diffraction, energy dispersive spectroscopy, and scanning electron microscopy techniques which show that the atomic ratio of Al and O elements is about 60:45 and the mass ratio is about 70:31. This point reveals that there is no intermediate layer between Al2O3 and the silicon substrate. In conclusion, this nanoparticle shows good electron conductivity at the surface of a carbon paste electrode that shows its ability in the preparation of a nanosensor in morphine analysis. The linear response range and detection limit were found to be 0.1–550 and 0.03 μmol L−1, respectively. The proposed sensor was successfully applied for the determination of morphine in real samples such as human urine and drug.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Scheme 1
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Pathak LC, Singh TB, Das S, Verma AK, Ramachandrarao P (2002) Mat Lett 57:380

    Article  CAS  Google Scholar 

  2. Karimi-Maleh H, Biparva P, Hatami M (2013) Biosens Bioelect 48:270

    Article  CAS  Google Scholar 

  3. Ensafi AA, Bahrami H, Karimi-Maleh H, Mallakpour S (2012) Chin J Catal 33:1919

    Article  CAS  Google Scholar 

  4. Raoof JB, Ojani R, Karimi-Maleh H (2010) Chin Chem Lett 21:1462

    Article  CAS  Google Scholar 

  5. Afzali D, Karimi-Maleh H, Khalilzadeh MA (2011) Environ Chem Lett 9:375

    Article  CAS  Google Scholar 

  6. Keyvanfard M, Khosravi V, Karimi-Maleh H, Alizad K, Rezaei B (2013) J Mol Liq 177:182

    Article  CAS  Google Scholar 

  7. Tok AIY, Boey FYC, Zhao XL (2006) J Mat Proc Tech 178:270

    Article  CAS  Google Scholar 

  8. Tikkanen J, Gross KA, Berndt CC, Pitkanen V, Keskinen J, Raghu S, Rajala M, Karthikeyan J (1997) Surf Coat Technol 90:210

    Article  CAS  Google Scholar 

  9. Wu YQ, Zhang Y, Huang X, Guo J (2001) Ceram Int 27:265

    Article  CAS  Google Scholar 

  10. Gupta VK, Ludwig R, Agarwal S (2005) Anal Chim Acta 538:213

    Article  CAS  Google Scholar 

  11. Ensafi AA, Izadi M (2013) Karimi-Maleh H 19:137

    CAS  Google Scholar 

  12. Fouladgar M, Karimi-Maleh H, Hosseinzadeh R (2013) Ionics 19:665

    Article  CAS  Google Scholar 

  13. Tavana T, Khalilzadeh MA, Karimi-Maleh H, Ensafi AA, Beitollahi H, Zareyee D (2012) J Mol Liq 168:69

    Article  CAS  Google Scholar 

  14. Fouladgar M, Karimi-Maleh H (2012) Ionics. doi:10.1007/s11581-012-0832-7

  15. Salmanpour S, Tavana T, Pahlavan A, Khalilzadeh MA, Ensafi AA, Karimi-Maleh H, Beitollahi H, Kowsari E, Zareyee D (2012) Mat Sci Eng C 32:1912

    Article  CAS  Google Scholar 

  16. Ensafi AA, Karimi-Maleh H, Mallakpour S, Rezaei B (2011) Coll Surf B 87:480

    Article  CAS  Google Scholar 

  17. Goyal RN, Gupta VK, Oyama M, Bachheti N (2007) Talanta 72:976

    Article  CAS  Google Scholar 

  18. Goyal RN, Gupta VK, Chatterjee S (2008) Electrochim Acta 53:5354

    Article  CAS  Google Scholar 

  19. Goyal RN, Gupta VK, Bachheti N, Avatar Sharma R (2008) Electroanalysis 20:757

    Article  CAS  Google Scholar 

  20. Goyal RN, Oyama M, Gupta VK, Singh SP, Sharma RA (2008) Sens Actuators B 134:816

    Article  CAS  Google Scholar 

  21. Gupta VK, Al Khayat M, Singh AK, Pal MK (2009) Anal Chim Acta 634:36

    Article  CAS  Google Scholar 

  22. Gupta VK, Agarwal S, Saleh TA (2011) Water Res 45:2207

    Article  CAS  Google Scholar 

  23. Gupta VK, Chandra S, Lang H (2005) Talanta 66:575

    Article  CAS  Google Scholar 

  24. Gupta VK, Chandra S, Mangla R (2002) Electrochim Acta 47:1579

    Article  CAS  Google Scholar 

  25. Gupta VK, Nayak A, Agarwal S, Singhal B (2011) Comb Chem High Through Scre 14:284

    Article  CAS  Google Scholar 

  26. Goyal RN, Gupta VK, Chatterjee S (2009) Biosens Bioelect 24:1649

    Article  CAS  Google Scholar 

  27. Goyal RN, Gupta VK, Sanghamitr C (2009) Biosens Bioelect 24:3562

    Article  CAS  Google Scholar 

  28. Ensafi AA, Karimi-Maleh H, Mallakpour S, Hatami M (2011) Sen Actuators B 155:464

    Article  CAS  Google Scholar 

  29. Beitollahi H, Karimi-Maleh H, Khabazzadeh H (2008) Anal Chem 80:9848

    Article  CAS  Google Scholar 

  30. Roodbari Shahmiri M, Bahari A, Karimi-Maleh H, Hosseinzadeh R, Mirnia N (2012) Sens Actuators B 177:70

    Article  CAS  Google Scholar 

  31. Beitollah H, Goodarzian M, Khalilzadeh MA, Karimi-Maleh H, Hassanzadeh M, Tajbakhsh M (2012) J Mol Liq 173:137

    Article  CAS  Google Scholar 

  32. Ensafi AA, Karimi-Maleh H (2010) J Electroanal Chem 640:75

    Article  CAS  Google Scholar 

  33. Fotouhi L, Bagheri Hashkavayi A, Heravi MM (2012) J Exp Nanosci. doi:10.1080/17458080.2011.624554

  34. Karimi-Maleh H, Ensafi AA, Beitollahi H, Nasiri V, Khalilzadeh MA, Biparva P (2012) Ionics 18:687

    Article  CAS  Google Scholar 

  35. Bijad M, Karimi-Maleh H, Khalilzadeh MA (2013) Food Anal Methods. doi:10.1007/s12161-013-9585-9

  36. Ensafi AA, Karimi-Maleh H, Mallakpour S (2013) Coll Surf B 104:186

    Article  CAS  Google Scholar 

  37. Morphine. Available at http://en.wikipedia.org/wiki/Morphine

  38. The American Society of Health-System Pharmacists. Morphine sulfate: oral concentrated solution. Available at http://www.ashp.org/DrugShortages/NotAvailable/bulletin.aspx?id=532. July 12, 2002; retrieved 3 April 2011

  39. Leis HJ, Fauler G, Raspotnig G, Windischhofer W (2000) J Chromatogr B 744:113

    Article  CAS  Google Scholar 

  40. Freiermuth M, Plasse JC (1997) J Pharm Biomed Anal 15:759

    Article  CAS  Google Scholar 

  41. Joel SP, Osborne RJ, Slevin ML (1992) J Chromatogr B 430:394

    Google Scholar 

  42. Rashid BA, Aherne GW, Katmeh MF, Kwasowski P, Stevenson D (1998) J Chromatogr A 797:245

    Article  CAS  Google Scholar 

  43. Huwyler J, Rufer S, Küsters E, Drewe J (1995) J Chromatogr B 674:57

    Article  CAS  Google Scholar 

  44. Zhang XX, Li J, Gao J, Sun L, Chang WB (2000) J Chromatogr A 895:1

    Article  CAS  Google Scholar 

  45. Barnett NW, Rolfe DG (1993) Anal Chim Acta 282:551

    Article  CAS  Google Scholar 

  46. Sheibani A, Reza Shishehbore M, Mirparizi E (2010) Spectrochim Acta Part A 77:535

    Article  CAS  Google Scholar 

  47. Afsharmanesh E, Karimi-Maleh H, Pahlavan A, Vahedi J (2013) J Mol Liq 181:8

    Article  CAS  Google Scholar 

  48. Pournaghi-Azar MH, Saadatirad A (2008) J Electroanal Chem 624:293

    Article  CAS  Google Scholar 

  49. Li F, Song J, Gao D, Zhang Q, Han D, Niu L (2009) Talanta 79:845

    Article  CAS  Google Scholar 

  50. Mokhtari A, Karimi-Maleh H, Ensafi AA, Beitollahi H (2012) Sens Actuators B 169:96

    Article  CAS  Google Scholar 

  51. Ho KC, Chen CY, Hsu HC, Chen LC, Shiesh SC, Lin XZ (2004) Biosens Bioelect 20:3

    Article  CAS  Google Scholar 

  52. Salimi A, Hallaj R, Khayatian GR (2005) Electroanalysis 17:873

    Article  CAS  Google Scholar 

  53. Ensafi AA, Izadi M, Rezaei B, Karimi-Maleh H (2012) J Mol Liq 174:42

    Article  CAS  Google Scholar 

  54. Atta NF, Galal A, Wassel AA, Ibrahim AH (2012) Int J Electrochem Sci 7:10501

    CAS  Google Scholar 

  55. Shishehbore MR, Zare HR, Nematollahi D (2012) J Electroanal Chem 665:45

    Article  CAS  Google Scholar 

  56. Atta NF, Galal A, Azab SM (2011) Analyst 136:4682

    Article  CAS  Google Scholar 

  57. Gupta VK J, Radhapyari K, Jadon N, Agarwal S (2011) Anal Biochem 408:179

    Article  CAS  Google Scholar 

  58. Gupta VK, Goyal RN, Sharma RA (2009) Anal Chim Acta 647:66

    Article  CAS  Google Scholar 

  59. Gupta VK, Singh AK, Gupta B (2007) Anal Chim Acta 583:340

    Article  CAS  Google Scholar 

  60. Goyal RN, Gupta VK, Bachheti N (2007) Anal Chim Acta 597:82

    Article  CAS  Google Scholar 

  61. Gupta VK, Prasad R, Kumar P, Mangla R (2000) Anal Chim Acta 420:19

    Article  CAS  Google Scholar 

  62. Gupta VK, Singh AK, Mehtab S, Gupta B (2006) Anal Chim Acta 566:5

    Article  CAS  Google Scholar 

  63. Gupta VK, Singh AK, Al Khayat M, Gupta B (2007) Anal Chim Acta 590:81

    Article  CAS  Google Scholar 

  64. Gupta VK, Jain AK, Kumar P (2006) Sens Actuators B 120:259

    Article  CAS  Google Scholar 

  65. Gupta VK, Jain AK, Maheshwari G, Lang H, Ishtaiwi Z (2006) Sens Actuators B 117:99

    Article  CAS  Google Scholar 

  66. Gupta VK, Jain AK, Kumar P, Agarwal S, Maheshwari G (2006) Sens Actuators B 113:182

    Article  CAS  Google Scholar 

  67. Gupta VK, Prasad R, Kumar A (2003) Talanta 60:149

    Article  CAS  Google Scholar 

  68. Goyal RN, Gupta VK, Sangal A, Bachheti N (2005) Electroanalysis 17:2217

    Article  CAS  Google Scholar 

  69. Kondoh K, Oginuma H, Aizawa T (2003) Mat Transactions 44:524

    Article  CAS  Google Scholar 

  70. Bahari A, Morgen P, Li ZS (2006) Surf Sci 600:2966

    Article  CAS  Google Scholar 

  71. Ensafi AA, Karimi-Maleh H, Ghiaci M, Arshadi M (2011) J Mater Chem 21:15022

    Article  CAS  Google Scholar 

  72. Ghiaci M, Sadeghi Z, Sedaghat ME, Karimi-Maleh H, Safaei-Ghomi J, Gil A (2010) Appl Catal A 381:121

    Article  CAS  Google Scholar 

  73. Arshadi M, Ghiaci M, Ensafi AA, Karimi-Maleh H, Suib SL (2011) J Mol Catal A 338:71

    CAS  Google Scholar 

  74. Keyvanfard M, Shakeri R, Karimi-Maleh H, Alizad K (2013) Mat Sci Eng C 33:811

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors wish to thank Sari Branch, Islamic Azad University for their support.

Author information

Authors and Affiliations

  1. Department of Chemistry, Sari Branch, Islamic Azad University, Sari, Iran

    Vahid Arabali

  2. Department of Physics, Science and Research Branch, Islamic Azad University, Mazandaran, Iran

    Roya Sadeghi

Authors
  1. Vahid Arabali
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roya Sadeghi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Vahid Arabali or Roya Sadeghi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arabali, V., Sadeghi, R. Surface properties of nano-Al2O3 film and its application in the preparation of morphine electrochemical sensor. Ionics 19, 1775–1782 (2013). https://doi.org/10.1007/s11581-013-0929-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11581-013-0929-7

Keywords

Search

Navigation