Skip to main content
SpringerLink
Log in

Langzeitprobleme pädiatrischer Patienten nach dem Transfer in die Erwachsenennephrologie

Long-term problems of pediatric patients after transition to adult nephrological care

  • Leitthema
  • Published:
Der Nephrologe Aims and scope

Zusammenfassung

Die Fortschritte in der Nierenersatztherapie haben ein Langzeitüberleben von Kindern mit chronischer Niereninsuffizienz ermöglicht. Heute sind es vor allem Langzeitkomplikationen, die eine normale Lebenserwartung und eine altersentsprechende Lebensqualität noch deutlich einschränken. Ein Teil dieser Langzeitprobleme ist durch das Auftreten der Nierenerkrankung im Kindesalter und durch extrarenale Organbeteiligung erklärt, ein anderer Teil durch spezielle krankheitsbedingte Langzeitkomplikationen und durch Probleme der langjährigen Nierenersatztherapie. Schulische Ausbildung, Berufsfindung und insbesondere die soziale Rehabilitation sind häufig beeinträchtigt. Besondere Bedeutung für das Langzeitüberleben hat die kardiovaskuläre Komorbidität.

Abstract

Advances in renal replacement therapy have made long-term survival in pediatric and adolescent patients with chronic kidney disease possible. However, long-term complications continue to restrict life expectancy and quality of life in these patients. Some of these long-term problems are caused by the onset of chronic kidney disease in childhood or by extrarenal organ involvement, while others are caused by particular disease-associated long-term complications as well as long-term renal replacement therapy. Education, career and in particular social rehabilitation are often adversely affected. The extent of cardiovascular comorbidity is of major importance for long-term survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Frei U, Schober-Halstenberg HJ (1999) Annual Report of the German Renal Registry 1998. QuaSi-Niere Task Group for Quality Assurance in Renal Replacement Therapy. Nephrol Dial Transplant 14:1085–1090

    Article  CAS  PubMed  Google Scholar 

  2. Heijden BJ van der, Dijk PC van, Verrier-Jones K et al (2004) Renal replacement therapy in children: data from 12 registries in Europe. Pediatr Nephrol 19:213–221

    Article  PubMed  Google Scholar 

  3. Hildebrandt F, Attanasio M, Otto E (2009) Nephronophthisis: disease mechanisms of a ciliopathy. J Am Soc Nephrol 20:23–35

    Article  CAS  PubMed  Google Scholar 

  4. Rizzoni G, Ehrich JH, Broyer M et al (1992) Rehabilitation of young adults during renal replacement therapy in Europe. 1. The presence of disabilities. Nephrol Dial Transplant 7:573–578

    CAS  PubMed  Google Scholar 

  5. Rosenkranz J, Bonzel KE, Bulla M et al (1992) Psychosocial adaptation of children and adolescents with chronic renal failure. Pediatr Nephrol 6:459–463

    Article  CAS  PubMed  Google Scholar 

  6. Rotundo A, Nevins TE, Lipton M et al (1982) Progressive encephalopathy in children with chronic renal insufficiency in infancy. Kidney Int 21:486–491

    Article  CAS  PubMed  Google Scholar 

  7. Warady BA, Belden B, Kohaut E (1999) Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy. Pediatr Nephrol 13:759–765

    Article  CAS  PubMed  Google Scholar 

  8. Ledermann SE, Scanes ME, Fernando ON et al (2000) Long-term outcome of peritoneal dialysis in infants. J Pediatr 136:24–29

    Article  CAS  PubMed  Google Scholar 

  9. Slickers J, Duquette P, Hooper S, Gipson D (2007) Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Pediatr Nephrol 22:565–572

    Article  PubMed  Google Scholar 

  10. Gipson DS, Hooper SR, Duquette PJ et al (2006) Memory and executive functions in pediatric chronic kidney disease. Child Neuropsychol 12:391–405

    Article  PubMed  Google Scholar 

  11. Mendley SR, Zelko FA (1999) Improvement in specific aspects of neurocognitive performance in children after renal transplantation. Kidney Int 56:318–323

    Article  CAS  PubMed  Google Scholar 

  12. Furth SL, Cole SR, Moxey-Mims M et al (2006) Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study. Clin J Am Soc Nephrol 1:1006–1015

    Article  PubMed  Google Scholar 

  13. Nissel R, Brazda I, Feneberg R et al (2004) Effect of renal transplantation in childhood on longitudinal growth and adult height. Kidney Int 66:792–800

    Article  PubMed  Google Scholar 

  14. Hocker B, Weber LT, Feneberg R et al (2009) Prospective, randomized trial on late steroid withdrawal in pediatric renal transplant recipients under cyclosporine microemulsion and mycophenolate mofetil. Transplantation 87:934–941

    Article  PubMed  Google Scholar 

  15. Sutherland S, Li L, Concepcion W et al (2009) Steroid-free immunosuppression in pediatric renal transplantation: rationale for and [corrected] outcomes following conversion to steroid based therapy. Transplantation 87:1744–1748

    Article  CAS  PubMed  Google Scholar 

  16. Nissel R, Lindberg A, Mehls O, Haffner D (2008) Factors predicting the near-final height in growth hormone-treated children and adolescents with chronic kidney disease. J Clin Endocrinol Metab 93:1359–1365

    Article  CAS  PubMed  Google Scholar 

  17. Fine RN, Martz K, Stablein D (2010) What have 20 years of data from the North American Pediatric Renal Transplant Cooperative Study taught us about growth following renal transplantation in infants, children, and adolescents with end-stage renal disease? Pediatr Nephrol 25:739–746

    Article  PubMed  Google Scholar 

  18. Haffner D, Schaefer F, Nissel R et al (2000) Effect of growth hormone treatment on the adult height of children with chronic renal failure. German Study Group for Growth Hormone Treatment in Chronic Renal Failure. N Engl J Med 343:923–930

    Article  CAS  PubMed  Google Scholar 

  19. Martin KJ, Olgaard K, Coburn JW et al (2004) Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy. Am J Kidney Dis 43:558–565

    Article  PubMed  Google Scholar 

  20. Tenbrock K, Kruppa S, Mokov E et al (2000) Analysis of muscle strength and bone structure in children with renal disease. Pediatr Nephrol 14:669–672

    Article  CAS  PubMed  Google Scholar 

  21. Weaver DJ Jr, Kimball TR, Knilans T et al (2008) Decreased maximal aerobic capacity in pediatric chronic kidney disease. J Am Soc Nephrol 19:624–630

    Article  PubMed  Google Scholar 

  22. Foley RN, Parfrey PS, Sarnak MJ (1998) Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32:S112–119

    Article  CAS  PubMed  Google Scholar 

  23. Oh J, Wunsch R, Turzer M et al (2002) Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation 106:100–105

    Article  PubMed  Google Scholar 

  24. Briese S, Wiesner S, Will JC et al (2006) Arterial and cardiac disease in young adults with childhood-onset end-stage renal disease-impact of calcium and vitamin D therapy. Nephrol Dial Transplant 21:1906–1914

    Article  CAS  PubMed  Google Scholar 

  25. Gruppen MP, Groothoff JW, Prins M et al (2003) Cardiac disease in young adult patients with end-stage renal disease since childhood: a Dutch cohort study. Kidney Int 63:1058–1065

    Article  PubMed  Google Scholar 

  26. Querfeld U, Anarat A, Bayazit AK et al (2010) The Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study: objectives, design, and methodology. Clin J Am Soc Nephrol 5:1642–1648

    Article  PubMed  Google Scholar 

  27. Ehrich JH, Rizzoni G, Broyer M et al (1992) Rehabilitation of young adults during renal replacement therapy in Europe. 2. Schooling, employment, and social situation. Nephrol Dial Transplant 7:579–586

    CAS  PubMed  Google Scholar 

  28. Querfeld U, Korten B, Naumann G, Michalk DV (1997) Medical and psychosocial rehabilitation of young adults receiving renal replacement therapy since childhood: a single-centre experience. Nephrol Dial Transplant 12:33–37

    Article  CAS  PubMed  Google Scholar 

  29. Kimmel PL, Peterson RA (2005) Depression in end-stage renal disease patients treated with hemodialysis: tools, correlates, outcomes, and needs. Semin Dial 18:91–97

    Article  PubMed  Google Scholar 

  30. Hoppe A, Puttkamer C von, Linke U et al (2010) Hospital-based intermittent nocturnal hemodialysis program for children and adolescents. J Pediatr

Download references

Interessenkonflikt

Keine Angaben

Author information

Authors and Affiliations

  1. Klinik für Pädiatrie mit Schwerpunkt Nephrologie, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland

    U. Querfeld

Authors
  1. U. Querfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to U. Querfeld.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Querfeld, U. Langzeitprobleme pädiatrischer Patienten nach dem Transfer in die Erwachsenennephrologie. Nephrologe 6, 51–54 (2011). https://doi.org/10.1007/s11560-010-0478-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11560-010-0478-2

Schlüsselwörter

Keywords

Search

Navigation