Skip to main content

Advertisement

SpringerLink
Log in

Contrast analysis of the relationship between the HRCT sign and new pathologic classification in small ground glass nodule-like lung adenocarcinoma

  • CHEST RADIOLOGY
  • Published:
La radiologia medica Aims and scope Submit manuscript

Abstract

Purpose

To perform contrast analysis of the relationship between high-resolution computed tomography (HRCT) signs and new pathologic classification of small GGNs-like lung adenocarcinoma.

Materials and methods

The HRCT data from 145 pathologically confirmed cases of small GGNs of lung adenocarcinoma were analysed retrospectively. The 145 cases of GGNs were divided into pre-invasive (PI) group (n = 46), micro-invasive adenocarcinoma (MIA) group (n = 48), and invasive adenocarcinoma (IAC) group (n = 51). HRCT imaging sign of GGNs in each group was assessed and compared.

Results

Significant differences in GGN size were found among the three groups (P < 0.05). The presence of a tumour–lung interface in the MIA and IAC groups was significantly higher than that in the PI group (P < 0.05), but no significant difference was found between the MIA and IAC groups. The presence of a pleural indentation sign in the IAC group was significantly higher than that in the other two groups (P < 0.05), but no significant difference was noted between the latter two groups. Significant differences were found in the lobulated and spicule signs among the three groups (P < 0.05). The presence of a microvascular sign in the MIA and IAC groups was significantly higher than that in the PI group (P < 0.05). No significant difference was found in the GGN density, vacuole sign, air bronchus sign and notch sign among the three groups.

Conclusions

The HRCT signs of GGNs could be used to differentiate among pre-invasive lesions, micro-invasive lesions and invasive lung adenocarcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Godoy MC, Naidich DP (2012) Overview and strategic management of subsolid pulmonary nodules. J Thorac Imaging 27:240–248

    Article  PubMed  Google Scholar 

  2. Lee HY, Choi YL, Lee KS et al (2014) Pure ground-glass opacity neoplastic lung nodules: histopathology, imaging, and management. AJR Am J Roentgenol 202:W224–W233

    Article  PubMed  Google Scholar 

  3. Kodama K, Higashiyama M, Yokouchi H et al (2001) Prognostic value of ground-glass opacity found in small lung adenocarcinoma on high-resolution CT scanning. Lung Cancer 33:17–25

    Article  CAS  PubMed  Google Scholar 

  4. Goo JM, Park CM, Lee HJ (2011) Ground-glass nodules on chest CT as imaging biomarkers in the management of lung adenocarcinoma. AJR 196:533–543

    Article  PubMed  Google Scholar 

  5. Travis WD, Brambilla E, Noguchi M et al (2011) International association for the study of lung cancer/american thoracic society/european respiratory society international muhidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6:244–285

    Article  PubMed  PubMed Central  Google Scholar 

  6. Yoshizawa A, Motoi N, Riely GJ et al (2011) Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol 24:653–664

    Article  CAS  PubMed  Google Scholar 

  7. Travis WD, Brambilla E, Riely GJ (2013) New pathologic classification of lung cancer: relevance for clinical practice and clinical trials. J Clin Oncol 31:992–1001

    Article  CAS  PubMed  Google Scholar 

  8. Lee SM, Park CM, Goo JM et al (2013) Invasive pulmonary adenocarcinomas versus preinvasive lesions appearing as ground-glass nodules: differentiation by using CT features. Radiology 268:265–273

    Article  PubMed  Google Scholar 

  9. Kazerooni EA (2001) High-resolution CT of the lungs. AJR 177:501–519

    Article  CAS  PubMed  Google Scholar 

  10. Min JH, Lee HY, Lee KS et al (2010) Stepwise evolution from a focal pure pulmonary ground-glass opacity nodule into an invasive lung adenocarcinoma: an observation for more than 10 years. Lung Cancer 69:123–126

    Article  PubMed  Google Scholar 

  11. Tsutani Y, Miyata Y, Nakayama H et al (2014) Appropriate sublobar resection choice ground glass opacity–dominant clinical stage IA adenocarcinoma. Wedge resection or segmentectomy. Chest 145:66–71

    Article  PubMed  Google Scholar 

  12. Sakurai H, Asamura H (2014) Sublobar resection for early-stage lung cancer. Transl Lung Cancer Res 3:164–172

    PubMed  PubMed Central  Google Scholar 

  13. Cho KS, Kim SJ, Lee YJ et al (2014) Surgical resection of nodular ground-glass opacities without percutaneous needle aspiration or biopsy. BMC Cancer 14:838

    Article  PubMed  PubMed Central  Google Scholar 

  14. Lim HJ, Ahn S, Lee KS et al (2013) Persistent pure ground-glass opacity lung nodules >/= 10 mm in diameter at CT scan: histopathologic comparisons and prognostic implications. Chest 144:1291–1299

    Article  PubMed  Google Scholar 

  15. Lee HY, Jeong JY, Lee KS et al (2012) Solitary pulmonary nodular lung adenocarcinoma: correlation of histopathologic scoring and patient survival with imaging biomarkers. Radiology 264:884–893

    Article  PubMed  Google Scholar 

  16. Eguchi T, Yoshizawa A, Kawakami S et al (2014) Tumor size and computed tomography attenuation of pulmonary pure ground-glass nodules are useful for predicting pathological invasiveness. PLoS ONE 9:e97867

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Fan L, Liu SY, Li QC et al (2012) Multidetector CT features of pulmonary focal ground-glass opacity: differences between benign and malignant. Br J Radiol 85:897–904

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Heo EY, Lee KW, Jheon S et al (2011) Surgical resection of highly suspicious pulmonary nodules without a tissue diagnosis. Jpn J Clin Oncol 41:1017–1022

    Article  PubMed  Google Scholar 

  19. Ichinose J, Kohno T, Fujimori S et al (2014) Invasiveness and malignant potential of pulmonary lesions presenting as pure ground-glass opacities. Ann Thorac Cardiovasc Surg 20:347–352

    Article  PubMed  Google Scholar 

  20. Nambu A, Araki T, Taguchi Y et al (2005) Focal area of ground-glass opacity and ground-glass opacity predominance on thin-section CT: discrimination between neoplastic and non-neoplastic lesions. Clin Radiol 60:1006–1017

    Article  CAS  PubMed  Google Scholar 

  21. Ito T, Murakawa T, Sato H et al (2012) Simple preoperative computed tomography image analysis shows good predictive performance for pathological vessel invasion in clinical stage IA non-small cell lung cancer. Interact CardioVasc Thorac Surg 15:633–638

    Article  PubMed  PubMed Central  Google Scholar 

  22. Liang J, Xu XQ, Xu H et al (2015) Using the CT features to differentiate invasive pulmonary adenocarcinoma from pre-invasive lesion appearing as pure or mixed ground-glass nodules. Br J Radiol 88:20140811

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank Mr. Zhang for the English revision.

Author information

Authors and Affiliations

  1. Department of Oncology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215001, China

    You Meng

  2. Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University, No. 16, bai-ta-xi Road, Suzhou, 215001, Jiangsu Province, China

    Chen-Lu Liu, Qing Cai, Yu-Ying Shen & Shuang-Qing Chen

Authors
  1. You Meng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chen-Lu Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qing Cai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu-Ying Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shuang-Qing Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shuang-Qing Chen.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Meng, Y., Liu, CL., Cai, Q. et al. Contrast analysis of the relationship between the HRCT sign and new pathologic classification in small ground glass nodule-like lung adenocarcinoma. Radiol med 124, 8–13 (2019). https://doi.org/10.1007/s11547-018-0936-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11547-018-0936-x

Keywords

Search

Navigation