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Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging

  • CARDIAC RADIOLOGY
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Abstract

Purpose

This study was conducted to assess the role of atrial function by cardiac magnetic resonance (CMR) for the evaluation of diastolic physiology in patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls.

Materials and methods

We enrolled 23 consecutive patients affected by HCM and 43 healthy subjects as age-matched control cases (CC). CMR was performed through acquisition of cine steady-state free precession sequences using a 1.5-T scanner. Image postprocessing was carried out using Tracking Tool software.

Results

Atrial volumes were significantly higher in patients with HCM compared to CC: maximum atrial volume (p = 0.007) and minimum atrial volume (p = 0.01). A statistically significant difference was also observed in atrial ejection fraction in patients with HCM (p < 0.0001). The atrial volume curves defined as cavity volume over time (dV/t) showed significant differences: early atrial peak emptying rate (PERE) (maximum rate of emptying independent of atrial contraction) in HCM was −146 ± 53 ml/s versus −227 ± 86 ml/s in CC (p < 0.0001); active atrial peak emptying rate (PERA) (maximum rate of emptying secondary to atrial contraction) in HCM was −256 ± 80 ml/s versus −216 ± 104 ml/s in CC (p = 0.05); the atrial PER E/A ratio in HCM was 0.6 ± 0.2 versus 1.05 ± 0.5 in CC (p < 0.0001).

Conclusions

This study demonstrated that in HCM patients with early diastolic dysfunction the parameters of left atrial function assessed by CMR are impaired before the ventricular diastolic indexes such as the early peak filling rate and the active peak filling rate.

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Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, DIBIMEF, University Hospital “P Giaccone” University of Palermo, Via del Vespro 127, 90127, Palermo, Italy

    Emanuele Grassedonio, Ludovico La Grutta, Patrizia Toia, Massimo Galia & Massimo Midiri

  2. Radiology Service, Department of Diagnostic and Therapeutic Services, Mediterranean Institute for Transplantation and Adavanced Specialized Therapies (ISMETT), Palermo, Italy

    Giovanni D. Gentile

  3. University Hospital “P Giaccone” University of Palermo, Via del Vespro 127, 90127, Palermo, Italy

    Federico Midiri

  4. Magnetic Resonance Imaging Unit, Fondazione CNR-Regione Toscana G. Monasterio, Pisa, Italy

    Giancarlo Todiere, Alessia Pepe & Giovanni Donato Aquaro

Authors
  1. Emanuele Grassedonio
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  2. Giancarlo Todiere
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  3. Ludovico La Grutta
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  4. Patrizia Toia
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  5. Giovanni D. Gentile
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  6. Massimo Galia
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  7. Federico Midiri
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  8. Alessia Pepe
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  9. Massimo Midiri
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  10. Giovanni Donato Aquaro
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Corresponding author

Correspondence to Emanuele Grassedonio.

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Grassedonio, E., Todiere, G., La Grutta, L. et al. Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging. Radiol med 120, 714–722 (2015). https://doi.org/10.1007/s11547-015-0497-1

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  • DOI: https://doi.org/10.1007/s11547-015-0497-1

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