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Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series

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Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Medical Oncology, Institut Bergonie, 229 Cours de l’Argonne, 33076, Bordeaux, France

    Antoine Italiano & Binh Bui

  2. Department of Radiology, Institut Bergonié, Bordeaux, France

    Michèle Kind

  3. Department of Medicine, Institut Gustave Roussy, Villejuif, France

    Angela Cioffi

  4. Sarcoma Service, Memorial Sloan-Kettering Cancer Center, New York, USA

    Robert G. Maki

  5. Mount Sinai School of Medicine, New York, NY, USA

    Robert G. Maki

Authors
  1. Antoine Italiano
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  2. Michèle Kind
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  3. Angela Cioffi
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  4. Robert G. Maki
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  5. Binh Bui
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Corresponding author

Correspondence to Antoine Italiano.

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Italiano, A., Kind, M., Cioffi, A. et al. Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series. Targ Oncol 8, 211–213 (2013). https://doi.org/10.1007/s11523-012-0251-8

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  • DOI: https://doi.org/10.1007/s11523-012-0251-8

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