Abstract
Despite extensive studies on the mechanics of DNA under external constrains, such as tension, torsion, and bending, several important aspects have remained poorly understood. One biologically important example is the mechanics of DNA under sharp bending conditions, which has been debated for a decade without thorough comprehension. The debate is about the interesting phenomenon raised from a series of different experiments: sharply bent DNA has a surprisingly high apparent bending flexibility that deviates from the canonical bending elasticity of DNA. This finding has motivated various theoretical models, which mainly incorporate the excitation of mechanical defects inside severely bent DNA molecules. Here, we review the recent progress on the understanding of the mechanics of sharply bent DNA and provide our view on this important question by interrogating the theoretical foundation of these experimental measurements.
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Cong, P., Yan, J. Recent progress on the mechanics of sharply bent DNA. Sci. China Phys. Mech. Astron. 59, 680001 (2016). https://doi.org/10.1007/s11433-016-0099-0
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DOI: https://doi.org/10.1007/s11433-016-0099-0