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Früherkennung und Primärprävention des Typ-1-Diabetes

„Global Platform for the Prevention of Autoimmune Diabetes“ (GPPAD)

Early detection and primary prevention of type 1 diabetes

Global Platform for the Prevention of Autoimmune Diabetes (GPPAD)

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Der Diabetologe Aims and scope

Zusammenfassung

Hintergrund

Die Typ-1-Diabetes ursächlich zugrunde liegende Autoimmunreaktion beginnt im frühen Kleinkindalter mit einem Inzidenzpeak der Betazellautoimmunität bei 12 Monaten und richtet sich primär gegen Insulin.

GPPAD („Global Platform for the Prevention of Autoimmune Diabetes“)

Dieses Netzwerk kooperierender Wissenschaftler aus verschiedenen europäischen Ländern will die Früherkennung eines erhöhten Risikos für Typ-1-Diabetes und die primäre Prävention von Betazellautoimmunität und dieser Stoffwechselerkrankung für Europa realisieren. Mittels eines neuen genetischen Risikoscores lassen sich direkt nach der Geburt Kinder identifizieren, deren Risiko für Typ-1-Diabetes im Vergleich zum Bevölkerungsdurchschnitt mindestens 25-fach erhöht ist. Diese Kinder können an der Primärpräventionsstudie POInT („primary oral insulin trial“) teilnehmen.

POInT

Es handelt sich um eine randomisierte, plazebokontrollierte Doppelblindstudie mit dem Ziel, durch Behandlung mit oralem Insulin im Kleinkindesalter die insulinspezifische Immuntoleranz zu verbessern.

Abstract

Background

Betacell autoimmunity, which leads to type 1 diabetes, starts in early childhood with a peak in incidence at 12 months and insulin is its primary target.

GPPAD (Global Platform for the Prevention of Autoimmune Diabetes)

This network of collaborating European scientists aims to realize the early detection of an elevated risk to develop type 1 diabetes and primary prevention of betacell autoimmunity and type 1 diabetes in Europe. A new genetic risk score can identify newborns with 25-fold increased risk of type 1 diabetes. These children can participate in a primary prevention trial called POInT (Primary Oral Insulin Trial).

POInT study

This is a randomized, placebo-controlled, double-blind clinical trial that will test the efficacy of oral insulin to prevent autoimmunity and type 1 diabetes.

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Authors and Affiliations

  1. Institut für Diabetesforschung, Helmholtz Zentrum München und Lehrstuhl für Diabetes und Gestationsdiabetes, Technische Universität München, Heidemannstr. 1, 80939, München, Deutschland

    A. G. Ziegler, J. Ohli, T. Hoefs, S. Aydin, C. Falk & J. Gross

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  1. A. G. Ziegler
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  2. J. Ohli
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  3. T. Hoefs
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  4. S. Aydin
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  5. C. Falk
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  6. J. Gross
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Corresponding author

Correspondence to A. G. Ziegler.

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Interessenkonflikt

A.G. Ziegler, J. Ohli, T. Hoefs, S. Aydin, C. Falk und J. Gross geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Ziegler, A.G., Ohli, J., Hoefs, T. et al. Früherkennung und Primärprävention des Typ-1-Diabetes. Diabetologe 14, 240–244 (2018). https://doi.org/10.1007/s11428-018-0337-8

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